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Beilstein J. Org. Chem. 2011, 7, 338–345, doi:10.3762/bjoc.7.44
Graphical Abstract
Figure 1: Diversity-based thieno[2,3-d]pyrimidine scaffold [7].
Scheme 1: Pd/C-mediated synthesis of 4-alkynyl-substituted thieno[2,3-d]pyrimidines.
Scheme 2: Preparation of 4-chloro-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidine 1d.
Scheme 3: Reactivity of 4-chlorothieno[2,3-d]pyrimidines 1 towards terminal alkynes and MeOH under Pd/C–Cu ca...
Scheme 4: Plausible mechanism of Pd/C-mediated alkynylation of 4-chlorothieno[2,3-d]pyrimidines 1.
Figure 2: Possible interactions of compounds 3f and 3g with TS enzyme.