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1 article(s) from Menegaki, Despoina

Heteroannulations of cyanoacetamide-based MCR scaffolds utilizing formamide

Marios Zingiridis,
Danae Papachristodoulou,
Despoina Menegaki,
Konstantinos G. Froudas and
Constantinos G. Neochoritis

Beilstein J. Org. Chem. 2025, 21, 217–225, doi:10.3762/bjoc.21.13

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Figure 1: Heteroannulated pyrimidones in drug discovery: blockbuster drugs that are based on the privileged p...

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Scheme 1: Strategies towards targeted adducts: A) Niementowski quinazoline synthesis utilizing anthranilic ac...

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Scheme 2: Access to the key building blocks 2–4 by employing three different nonisocyanide-based MCRs. Divers...

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Scheme 3: Synthesis of N-substituted thienopyrimidones 5a–e by a Gewald three-component reaction employing 2-...

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Scheme 4: Synthesis of N-substituted quinolinopyrimidones 6a–e from 2-aminoindoles 3a–e and formamide as C1 s...

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Scheme 5: Synthesis of N-substituted indolopyrimidones 7a–e from 2-aminoindoles 4a–e and formamide as C1 sour...

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Figure 2: Representative fluorescence spectrum of compounds 5b (λ_ex = 330 nm) and 6e (λ_ex = 430 nm) at 0.2 M ...

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Figure 3: Molecular geometry observed within the crystal structure of compound 7b (CCDC 2376493).

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Published 24 Jan 2025

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