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Beilstein J. Org. Chem. 2024, 20, 2455–2460, doi:10.3762/bjoc.20.209
Graphical Abstract
Figure 1: Functional molecules containing a substituted pyrrolidine core.
Scheme 1: A) Our previous report on N-alkenylamide cyclizations. B) An overview of the present work.
Scheme 2: Calculated mechanism for the cyclization of amide 3a optimized at the B3LYP/ 6-31+G(d,p) level of t...
Scheme 3: Scope of cyclization reaction.
Scheme 4: Reactions of di- and trisubstituted alkene substrates.
Beilstein J. Org. Chem. 2017, 13, 1823–1827, doi:10.3762/bjoc.13.177
Scheme 1: Our previous and current iodoarene-catalyzed cyclizations.
Figure 1: Examples of biologically-active compounds containing an oxazoline ring.
Scheme 2: 2-Iodoanisole-catalyzed cyclization of N-propargylamides.
Scheme 3: Postulated mechanism for N-propargylamide cyclization.
Scheme 4: Synthesis of β-amidoketones 5.
Scheme 5: 2-Iodoanisole-catalyzed cyclization of β-amidoketones 5.
Scheme 6: In situ oxazoline ring hydrolysis.
Scheme 7: Postulated mechanism for cyclization of β-amidoketones.