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Beilstein J. Org. Chem. 2025, 21, 226–233, doi:10.3762/bjoc.21.14
Graphical Abstract
Figure 1: Representative bis-tetrahydroisoquinoline (THIQ) alkaloids and their analogues. Oxygen atoms on bot...
Scheme 1: Strategies for the construction of the pentacyclic core scaffold of saframycin A (1). (a) Biosynthe...
Scheme 2: Streamlined synthesis of the substructure 14 for saframycins 1 within just four steps in overall 29...
Figure 2: UV–vis absorption (gray solid line), the emission spectrum (blue solid line), and the corresponding...
Beilstein J. Org. Chem. 2024, 20, 1693–1712, doi:10.3762/bjoc.20.151
Scheme 1: Targeted natural products and key enzymatic transformations in the chemo-enzymatic total syntheses ...
Scheme 2: Biosynthetic pathway to brassicicenes in Pseudocercospora fijiensis [14]. (A) Cyclization phase catalyz...
Scheme 3: Chemo-enzymatic total synthesis of cotylenol (1) and brassicicenes. (A) Chemical cyclization phase....
Scheme 4: (A) Biosynthetic pathway for trichodimerol (2) in Penicillium chrysogenum. (B) Chemo-enzymatic tota...
Scheme 5: (A) Proposed biosynthetic pathway for chalcomoracin (3) in Morus alba. (B) Outline of the biosynthe...
Scheme 6: (A) Chemo-enzymatically synthesized natural products by using the originally identified MaDA. (B) M...
Scheme 7: Proposed biosynthetic mechanism of tylactone (4) in Streptomyces fradiae.
Scheme 8: (A) Chemical synthesis and cascade enzymatic transformations of cyclization precursors. (B) Late-st...
Scheme 9: Proposed biosynthetic mechanism of saframycin A (5) in Streptomyces lavendulae.
Scheme 10: (A) Chemo-enzymatic total synthesis of saframycin A (5) and jorunnamycin A (103). (B) Chemo-enzymat...
Beilstein J. Org. Chem. 2012, 8, 930–940, doi:10.3762/bjoc.8.105
Figure 1: (a) Biosynthetic outline of aromatic polyketides; (b) structure of indole alkaloids composed of ind...
Figure 2: (a) Synthetic plans based on modular assembly and divergent cyclizations leading to fused skeletons...
Scheme 1: Four-step synthesis of hexacyclic skeleton 25.
Scheme 2: Four-step synthesis of hexacyclic skeleton 30.
Scheme 3: Parallel and four-step synthesis of tetracyclic skeletons 39–42 and 47–48.
Scheme 4: Synthesis of branched precursors, 51 and 52, using amines 49 and 50, with different methylene lengt...
Scheme 5: Four-step synthesis of hexacyclic scaffold 63 employing manifold 15. For details of the synthesis o...