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Beilstein J. Org. Chem. 2025, 21, 473–482, doi:10.3762/bjoc.21.34
Graphical Abstract
Scheme 1: Previous work.
Scheme 2: Hypothesis, retro-Michael reaction, and its application in kinetic resolution.
Scheme 3: Model reaction.
Scheme 4: Kinetic resolution of the Michael adduct 1.
Scheme 5: Chemical correlation of 3 with 19.
Scheme 6: Epimerization of the anti-1 adduct promoted by A.
Beilstein J. Org. Chem. 2016, 12, 628–635, doi:10.3762/bjoc.12.61
Figure 1: Parent and supported bifunctional thioureas used in this work.
Scheme 1: Reaction of nitrostyrene with diethyl malonate and 2-ethoxycarbonyl cyclopentanone.
Scheme 2: Reaction of nitrostyrenes with malonates and β-diketones.
Scheme 3: Reaction of nitrostyrenes with β-keto esters and β-dicarbonyl compounds.
Scheme 4: Reaction of nitrostyrenes with α-nitrocyclohexanone and ethyl α-nitropropionate.