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Beilstein J. Org. Chem. 2025, 21, 490–499, doi:10.3762/bjoc.21.36
Graphical Abstract
Figure 1: a) Structural similarity of N-acetyl diazocine 1 with known 17βHSD3-inhibitor tetrahydrodibenzazoci...
Figure 2: The halogen-substituted N-acetyl diazocines 2–4 were used as the starting compounds for further der...
Scheme 1: Synthesis of amino-N-acetyl diazocine by deprotection of the carbamate.
Scheme 2: Reaction conditions for the attempted Ullmann-type reaction with sodium azide.
Scheme 3: Reaction conditions for the palladium-catalyzed introduction of a nitrile functionality.
Beilstein J. Org. Chem. 2021, 17, 1503–1508, doi:10.3762/bjoc.17.107
Figure 1: Bridged diazocines synthesized and investigated in this work.
Scheme 1: Synthesis of 3-bromo- and 3-iodo-acetylated CH2NR diazocines 10 (R = Ac) and formylated diazocines ...
Figure 2: UV–vis spectra of 3-bromo and 3-iodo, and unsubstituted CH2NAc-bridged (10a–c) and CH2NCHO-bridged (...
Figure 3: UV–vis spectra of 3-bromo-NAc-diazocine 10a and N-formyl-diazocine 11c in water. Spectra of Z-isome...