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1 article(s) from Trenin, Alexey S.

Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines

Dmitriy Yu. Vandyshev,
Daria A. Mangusheva,
Khidmet S. Shikhaliev,
Kirill A. Scherbakov,
Oleg N. Burov,
Alexander D. Zagrebaev,
Tatiana N. Khmelevskaya,
Alexey S. Trenin and
Fedor I. Zubkov

Beilstein J. Org. Chem. 2024, 20, 2806–2817, doi:10.3762/bjoc.20.236

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Figure 1: Some biologically active compounds and organic fluorophores containing the imidazo[1,2-a]pyrimidine...

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Figure 2: Existing approaches to imidazo[1,2-a]pyrimidines.

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Scheme 1: Reaction of 2-aminoimidazole (1) with N-substituted maleimides (2) and N-arylitaconimides (3).

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Scheme 2: Plausible synthetic routes for the interaction of N-substituted maleimides 2 with 2-aminoimidazole (...

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Scheme 3: Plausible synthetic routes for the interaction of or N-arylitaconimides 3 with 2-aminoimidazole (1)....

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Figure 3: Key correlations observed in the NOESY and HMBC spectra of the products 4d and 5d.

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Scheme 4: Results of MEP calculations for the reaction of N-phenylmaleimide (2a) with 2-aminoimidazole (1).

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Scheme 5: Results of MEP calculations for the reaction of N-phenylithaconimide (3a) with 2-aminoimidazole (1)....

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Figure 4: Structures of imidazo[1,2-a]pyrimidines selected for docking and voriconazole selected for comparis...

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Figure 5: (A) Position of the (S)-isomer of compound 4e in the active site of CYP51 after molecular docking^a....

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Published 05 Nov 2024

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