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Beilstein J. Org. Chem. 2025, 21, 2703–2715, doi:10.3762/bjoc.21.208
Graphical Abstract
Scheme 1: Structure of reactant (chalcone, compound A), geminal product (compound B), vicinal product (compou...
Scheme 2: Reaction mechanism of ditosyloxylation of chalcones with X = -OCH3 , -SCH3 followed by 1,2-aryl mig...
Scheme 3: Reaction mechanism of ditosyloxylation of chalcones with X = -Cl, -NO2 leading to the formation of ...
Figure 1: Relative Gibbs free energy profile for HTIB-mediated ditosyloxylation of chalcone with X = -SCH3 in...
Figure 2: Relative Gibbs free energy profile for HTIB-mediated ditosyloxylation of chalcone with X = -Cl invo...
Figure 3: Relative Gibbs free energy profile for HTIB-mediated ditosyloxylation of chalcone with X = -NO2 inv...
Scheme 4: Reaction mechanism of ditosyloxylation of chalcones with X = -OCH3, -SCH3, -Cl, -NO2 leading to the...
Figure 4: Relative Gibbs free energy profile for HTIB-mediated ditosyloxylation of chalcone with X = -OCH3 le...
Figure 5: Relative Gibbs free energy profile for HTIB-mediated ditosyloxylation of chalcone with X = -SCH3 le...
Figure 6: Relative Gibbs free energy profile for HTIB-mediated ditosyloxylation of chalcone with X = -Cl lead...
Figure 7: Relative Gibbs free energy profile for HTIB-mediated ditosyloxylation of chalcone with X = -NO2 lea...
Beilstein J. Org. Chem. 2023, 19, 231–244, doi:10.3762/bjoc.19.22
Figure 1: Representative drug molecules based on pyrazole, thioamide, and amide derivatives.
Figure 2: Previous and present findings for the synthesis of thioamide derivatives.
Scheme 1: Synthesis of pyrazole C-3-tethered thioamides.
Scheme 2: Synthesis of pyrazole C-4-tethered thioamides.
Scheme 3: Metal- and catalyst-free preparation of pyrazole C-5-linked thioamide conjugates.
Scheme 4: Synthesis of 4-iodopyrazole C-3-tethered thioamides.
Scheme 5: Gram-scale scope of the current protocol.
Scheme 6: Control experiment.
Scheme 7: H2O2-mediated synthesis of pyrazole-pyridine conjugates with amide tethers.
Scheme 8: Synthesis of pyrazole-pyridine conjugates 9F and 10F having amide tethers.
Scheme 9: A tentative mechanism for the formation of pyrazole conjugates with thioamide and amide linkage.
Beilstein J. Org. Chem. 2007, 3, No. 20, doi:10.1186/1860-5397-3-20
Scheme 1: Conversion of coumarin-4-one oximes to 3-alkyl-1,2-benzisoxazole derivatives.
Scheme 2: Reactions of 3-halomethyl derivatives with other nucleophiles.
Scheme 3: Sultone oximes and its precursor ketones.
Scheme 4: Synthesis of 1,2-benzoxathiin-4(3H)-one-2,2-dioxide 6 from methanesulfonate of salicylaldehyde.
Scheme 5: Preparation of 1,2-benzoxathiin-4(3H)-one-2,2-dioxides.
Scheme 6: Preparation of sultone oximes.
Scheme 7: Preparation of 3-alkyl-1,2-benzisoxazole derivatives.
Scheme 8: Synthesis of zonisamide from 1,2-benzisoxazole-3-methane-sulfonate.