Beyond symmetric self-assembly and effective molarity: unlocking functional enzyme mimics with robust organic cages

• Keith G. Andrews

Beilstein J. Org. Chem. 2025, 21, 421–443, doi:10.3762/bjoc.21.30

• , means there are opportunities in robust organic cage research not present in any other type of cavity currently explored. Automation and calculation in cavity synthesis and study The computational discovery of new materials has advanced in recent years with increased computational power [405]. Imine

Visible-light-promoted radical cyclisation of unactivated alkenes in benzimidazoles: synthesis of difluoromethyl- and aryldifluoromethyl-substituted polycyclic imidazoles

• Yujun Pang,
• Jinglan Yan,
• Nawaf Al-Maharik,
• Qian Zhang,
• Zeguo Fang and
• Dong Li

Beilstein J. Org. Chem. 2025, 21, 234–241, doi:10.3762/bjoc.21.15

• Yujun Pang Jinglan Yan Nawaf Al-Maharik Qian Zhang Zeguo Fang Dong Li New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base, Hubei University of Technology, 430068 Wuhan, China Department of chemistry, Faculty of Science, An Najah National University, Nablus

A review of recent advances in electrochemical and photoelectrochemical late-stage functionalization classified by anodic oxidation, cathodic reduction, and paired electrolysis

• Nian Li,
• Ruzal Sitdikov,
• Ajit Prabhakar Kale,
• Joost Steverlynck,
• Bo Li and
• Magnus Rueping

Beilstein J. Org. Chem. 2024, 20, 2500–2566, doi:10.3762/bjoc.20.214

Machine learning-guided strategies for reaction conditions design and optimization

• Lung-Yi Chen and
• Yi-Pei Li

Beilstein J. Org. Chem. 2024, 20, 2476–2492, doi:10.3762/bjoc.20.212

• ], and reaction conditions optimization [13]. These techniques have also been integrated with robotic platforms to speed up the discovery and synthesis of new materials and drug candidates, showcasing the potential and promising benefits of self-driving chemistry labs [19]. Raghavan et al. [20] compared

Synthesis and characterization of 1,2,3,4-naphthalene and anthracene diimides

• Adam D. Bass,
• Daniela Castellanos,
• Xavier A. Calicdan and
• Dennis D. Cao

Beilstein J. Org. Chem. 2024, 20, 1767–1772, doi:10.3762/bjoc.20.155

• periphery of the aromatic core to yield different structural isomers is effective for producing interesting new materials. Ourselves and others have investigated 1,2,3,4-benzene diimide, also known as mellophanic diimide [1], as a building block for heteroacenes [2][3][4][5] and polyimides [6][7][8]. The

Organic electron transport materials

• Joseph Cameron and
• Peter J. Skabara

Beilstein J. Org. Chem. 2024, 20, 672–674, doi:10.3762/bjoc.20.60

• of papers tackling many different aspects relating to organic electron transport materials from leaders across the world from this research community. We hope that these excellent works can act as inspiration for researchers looking to develop new materials or implement these in devices. We give our

A series of perylene diimide cathode interlayer materials for green solvent processing in conventional organic photovoltaics

• Kathryn M. Wolfe,
• Shahidul Alam,
• Eva German,
• Fahad N. Alduayji,
• Maryam Alqurashi,
• Frédéric Laquai and
• Gregory C. Welch

Beilstein J. Org. Chem. 2023, 19, 1620–1629, doi:10.3762/bjoc.19.119

• new materials with studious strategies to negate these issues and contribute to the movement for the commercialization of OPVs [7][8][9]. Cathode interlayers (CILs) have been recently recognized as a key component to realize highly efficient OPVs. Indeed, the highest efficiency to date reported at

Cyclodextrins as building blocks for new materials

• Miriana Kfoury and
• Sophie Fourmentin

Beilstein J. Org. Chem. 2023, 19, 889–891, doi:10.3762/bjoc.19.66

• Miriana Kfoury Sophie Fourmentin Université du Littoral Côte d'Opale, Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV, UR 4492), 59140 Dunkerque, France 10.3762/bjoc.19.66 Keywords: building blocks; cyclodextrins; new materials; The continuous increase in the number of

Comparative study of thermally activated delayed fluorescent properties of donor–acceptor and donor–acceptor–donor architectures based on phenoxazine and dibenzo[a,j]phenazine

• Saika Izumi,
• Prasannamani Govindharaj,
• Anna Drewniak,
• Paola Zimmermann Crocomo,
• Satoshi Minakata,
• Leonardo Evaristo de Sousa,
• Piotr de Silva,
• Przemyslaw Data and
• Youhei Takeda

Beilstein J. Org. Chem. 2022, 18, 459–468, doi:10.3762/bjoc.18.48

• Materials: Creation of New Materials Science for Environment-Friendly and Active Functions” (JSPS KAKENHI Grant Number JP19H05716) from the MEXT (Ministry of Education, Culture, Science and Technology, Japan), a Grant-in-Aid for Scientific Research (B) (JSPS KAKENHI Grant Number JP20H02813), and the

Free-radical cyclization approach to polyheterocycles containing pyrrole and pyridine rings

• Ivan P. Mosiagin,
• Olesya A. Tomashenko,
• Dar’ya V. Spiridonova,
• Mikhail S. Novikov,
• Sergey P. Tunik and
• Alexander F. Khlebnikov

Beilstein J. Org. Chem. 2021, 17, 1490–1498, doi:10.3762/bjoc.17.105

• heteroaromatics available for various applications. Fused polyheteroarenes, containing a pyrrole moiety, are widely present in natural products and pharmacologically important agents and have a significant importance in the development of new materials useful for bioimaging applications and chemosensor systems [3

Tuning the solid-state emission of liquid crystalline nitro-cyanostilbene by halogen bonding

• Subrata Nath,
• Alexander Kappelt,
• Matthias Spengler,
• Bibhisan Roy,
• Jens Voskuhl and
• Michael Giese

Beilstein J. Org. Chem. 2021, 17, 124–131, doi:10.3762/bjoc.17.13

• [22]. This readily accessible class of fluorophores can easily be modified and attached to other functional entities, thus it has become a promising candidate for the design of new materials for optoelectronic applications [23]. Recently, it was successfully employed as a fluorescent moiety in the

Synthesis of purines and adenines containing the hexafluoroisopropyl group

• Viacheslav Petrov,
• Rebecca J. Dooley,
• Alexander A. Marchione,
• Elizabeth L. Diaz,
• Brittany S. Clem and
• William Marshall

Beilstein J. Org. Chem. 2020, 16, 2739–2748, doi:10.3762/bjoc.16.224

• ) and used without further purification. CsF (Sigma-Aldrich) was dried in vacuum and stored and handled inside a glove box. Compound 1 was prepared according to a literature procedure [24], purity 96–98% and was used without further purification. The purity of the new materials, determined by GC and NMR

• tetrakis(trifluoromethyl)-1,3-dithietane (1) with compounds 2–7. Reaction products, conditions, yield, ratio of isomers, and melting points for the new materials. Enthalpy and entropy of activation for the rotameric interconversion of a subset of hexafluoroisopropyl azoles. NMR and MS data for the

Optical detection of di- and triphosphate anions with mixed monolayer-protected gold nanoparticles containing zinc(II)–dipicolylamine complexes

• Lena Reinke,
• Julia Bartl,
• Marcus Koch and
• Stefan Kubik

Beilstein J. Org. Chem. 2020, 16, 2687–2700, doi:10.3762/bjoc.16.219

• Lena Reinke Julia Bartl Marcus Koch Stefan Kubik Fachbereich Chemie - Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Straße, 67663 Kaiserslautern, Germany, Fax: +49-631-205-3921 INM – Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany 10.3762

Synthesis of novel multifunctional carbazole-based molecules and their thermal, electrochemical and optical properties

• Nuray Altinolcek,
• Ahmet Battal,
• Mustafa Tavasli,
• William J. Peveler,
• Holly A. Yu and
• Peter J. Skabara

Beilstein J. Org. Chem. 2020, 16, 1066–1074, doi:10.3762/bjoc.16.93

• [21][22][23]. Research continues on carbazole derivatives to find new materials with novel properties. It is therefore essential that one should design a molecule that has multifunctional usage in many different areas of technology [24]. Since carbazole is a relatively inexpensive material with unique

Photophysics and photochemistry of NIR absorbers derived from cyanines: key to new technologies based on chemistry 4.0

• Bernd Strehmel,
• Christian Schmitz,
• Ceren Kütahya,
• Yulian Pang,
• Anke Drewitz and
• Heinz Mustroph

Beilstein J. Org. Chem. 2020, 16, 415–444, doi:10.3762/bjoc.16.40

Click chemistry towards thermally reversible photochromic 4,5-bisthiazolyl-1,2,3-triazoles

• Chenxia Zhang,
• Kaori Morinaka,
• Mahmut Kose,
• Takashi Ubukata and
• Yasushi Yokoyama

Beilstein J. Org. Chem. 2019, 15, 2161–2169, doi:10.3762/bjoc.15.213

• been used many times to connect two functional molecules. When the Ru(I)-catalyzed Huisgen reaction is employed to connect two functional molecules, the linker itself possesses the thermally reversible photochromic property. Thus, this work can open the door to the creation of promising new materials

N-doped carbon dots covalently functionalized with pillar[5]arenes for Fe³⁺ sensing

• Jia Gao,
• Ming-Xue Wu,
• Dihua Dai,
• Zhi Cai,
• Yue Wang,
• Wenhui Fang,
• Yan Wang and
• Ying-Wei Yang

Beilstein J. Org. Chem. 2019, 15, 1262–1267, doi:10.3762/bjoc.15.123

• -University Cooperative Construction Project – Special Funds for New Materials (SXGJSF2017-3) for financial support.

Precious metal-free molecular machines for solar thermal energy storage

• Meglena I. Kandinska,
• Snejana M. Kitova,
• Vladimira S. Videva,
• Stanimir S. Stoyanov,
• Stanislava B. Yordanova,
• Stanislav B. Baluschev,
• Silvia E. Angelova and
• Aleksey A. Vasilev

Beilstein J. Org. Chem. 2019, 15, 1096–1106, doi:10.3762/bjoc.15.106

• regarded as realistic technological systems for long-term solar energy storage. However, the design and preparation of molecules matching all the above-mentioned criteria is quite difficult. Thus, the invention of new materials possessing at least parts of these requirements provides the base for further

Halogen bonding and host–guest chemistry between N-alkylammonium resorcinarene halides, diiodoperfluorobutane and neutral guests

• Fangfang Pan,
• Mohadeseh Dashti,
• Michael R. Reynolds,
• Kari Rissanen,
• John F. Trant and
• Ngong Kodiah Beyeh

Beilstein J. Org. Chem. 2019, 15, 947–954, doi:10.3762/bjoc.15.91

• supramolecular chemistry and materials science [1][2][3]. New systems both help us to better understand the nature and impetus behind the self-assembly of these fascinating systems, while also providing new materials that can provide the basis for a wide number of applications [4][5]. Halogen bonding (XB), as a

Some mechanistic aspects regarding the Suzuki–Miyaura reaction between selected ortho-substituted phenylboronic acids and 3,4,5-tribromo-2,6-dimethylpyridine

• Piotr Pomarański,
• Piotr Roszkowski,
• Jan K. Maurin,
• Armand Budzianowski and
• Zbigniew Czarnocki

Beilstein J. Org. Chem. 2018, 14, 2384–2393, doi:10.3762/bjoc.14.214

• ). Considering further applications of atropisomeric arylated pyridines in the design of new materials like molecular switches [4], it would be desirable to estimate their thermal stability. We therefore performed kinetic experiments in order to establish the value of the barrier to rotation in the

Efficient catenane synthesis by cucurbit[6]uril-mediated azide–alkyne cycloaddition

• Antony Wing Hung Ng,
• Chi-Chung Yee,
• Kai Wang and
• Ho Yu Au-Yeung

Beilstein J. Org. Chem. 2018, 14, 1846–1853, doi:10.3762/bjoc.14.158

• mechanically interlocked macrocycles. The flexible but strong mechanical bond between the interlocked macrocycles offers a unique opportunity for exploiting catenanes as molecular machines or new materials with unusual mechanical properties [1][2][3][4][5][6][7][8][9]. Over the years, different templates and

Hyper-reticulated calixarene polymers: a new example of entirely synthetic nanosponge materials

• Alberto Spinella,
• Marco Russo,
• Antonella Di Vincenzo,
• Delia Chillura Martino and
• Paolo Lo Meo

Beilstein J. Org. Chem. 2018, 14, 1498–1507, doi:10.3762/bjoc.14.127

• polystyrenes [51][52][53]. Moreover, the preparation of our materials, unlike hyper-crosslinked polystyrenes [48][49], requires the use of no porogen additive. Hence, our new materials benefit from significant advantages. Considering that polystyrenes have been used also as supporting materials for nanosized

Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones

• Sergii V. Melnykov,
• Andrii S. Pataman,
• Yurii V. Dmytriv,
• Svitlana V. Shishkina,
• Mykhailo V. Vovk and
• Volodymyr A. Sukach

Beilstein J. Org. Chem. 2017, 13, 2617–2625, doi:10.3762/bjoc.13.259

• Organofluorine compounds now play an essential role in the development of new materials for solar cells [1][2][3], radiotracers for PET imaging [4], agrochemicals [5][6], sensitive chemical probes for 19F nuclear magnetic resonance investigation of biological experiments [7][8], and are most widely used in the

Spatial effects in polymer chemistry

• Helmut Ritter

Beilstein J. Org. Chem. 2017, 13, 2015–2016, doi:10.3762/bjoc.13.198

• polymer chains. Here, the LCST effects fit into the dynamic, space-spreading strength model. I am convinced that this systematic approach provides the insights to allow a targeted and rapid development of new materials and methods. Findings concerned with spatial effects can be further explored by modern

New bio-nanocomposites based on iron oxides and polysaccharides applied to oxidation and alkylation reactions

• Daily Rodríguez-Padrón,
• Alina M. Balu,
• Antonio A. Romero and
• Rafael Luque

Beilstein J. Org. Chem. 2017, 13, 1982–1993, doi:10.3762/bjoc.13.194

• object of most research from our group over the past years [10][20][21][22]. One of the main challenges in the field of catalysis is the preparation of new materials to replace the traditional catalysts quickly, cheaply and efficiently [5]. In this regard, mechanochemical synthesis has become one of the

• and dopamine (DA)-coated metal oxide MNPs [30][31]. On the other hand, nature has inspired many scientists to innovate and design new materials. The miniaturization and efficiency achieved by entities in nature for energy production, biometabolite, photo-processing and resource maximization has always