Search results
Search for "benzodiazepine" in Full Text gives 31 result(s) in Beilstein Journal of Organic Chemistry.
Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization
Beilstein J. Org. Chem. 2012, 8, 1901–1908, doi:10.3762/bjoc.8.220
- in the literature. β-Carbolines are some of the most widely distributed alkaloids, associated with activities ranging from antineoplastic (tubulin binding) [44][45][46], anticonvulsive, hypnotic and anxiolytic (benzodiazepine receptor ligands) [47], antimicrobial as well as topoisomerase-II
Photochemical and thermal intramolecular 1,3-dipolar cycloaddition reactions of new o-stilbene-methylene-3-sydnones and their synthesis
Beilstein J. Org. Chem. 2011, 7, 1663–1670, doi:10.3762/bjoc.7.196
- cyclization of the formed nitrile imine intermediate leading to benzodiazepine ring closure (G, Figure 3) was the main intramolecular process [22]. In a continuation of our interest in the synthesis of heteropolycyclic compounds we extended our research to new stilbene-sydnone derivatives 3 (Figure 3). In
Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones
Beilstein J. Org. Chem. 2011, 7, 1124–1129, doi:10.3762/bjoc.7.129
- in good yield. Modification of the procedure allowed the preparation of benzodiazepine 9i. Relationship between residence time and relative composition of the crude reaction mixture. Products of aryl azide photolysis. Optimisation of the photolysis of aryl azide 8a. Preparation of side product 10
An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals
Beilstein J. Org. Chem. 2011, 7, 442–495, doi:10.3762/bjoc.7.57
- a purity of >99.5% which is by far superior to the previously reported synthesis [65]. Finally, hydrolysis of the methyl ester provides telmisartan in an overall yield of about 50% compared to 21% as previously obtained (Scheme 44). Imidazopyridine Zolpidem (227) is a non-benzodiazepine hypnotic
- third ring has been found to impact greatly on the pharmacological profile of these drugs. A representative of this compound class is alprazolam (297, Xanax) which contains a 1,2,4-triazole fused to the benzodiazepine core. The synthesis of this molecule [87][88] (Scheme 58) can be accomplished in a
- can then be converted into its thioamide analogue 301 with P2S5 in pyridine. Finally, the reaction of 301 with acetyl hydrazide (291) catalysed by acetic acid furnishes the triazole ring fused to the benzodiazepine core. Another approach [89] makes use of 1,4-benzodiazepine-N-nitrosamidine 302 as the
Synthesis of dihydrophenanthridines by a sequence of Ugi-4CR and palladium- catalyzed intramolecular C-H functionalization
Beilstein J. Org. Chem. 2008, 4, No. 10, doi:10.3762/bjoc.4.10
- developed two-step syntheses of a number of macrocycles including cyclophanes and cyclodepsipeptides [7][8][9][10]. We have also reported the elaboration of Ugi-adduct containing two arylhalide functions for the synthesis of 1,4-benzodiazepine-2,5-diones [11] and their tetracyclic derivatives [12] featuring
One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines
Beilstein J. Org. Chem. 2006, 2, No. 5, doi:10.1186/1860-5397-2-5
- minor tranquiliser, a large number of seven-membered heterocyclic compounds with the benzodiazepine moiety have been synthesized and tested for psychotropic properties.[29] This moiety has been found to represent a versatile template in peptidomimetic design and it is also found in several other
- compounds of biological importance including anti-tumor antibiotics and inhibitors of HIV-1 transcriptase.[30] New methods continue to appear in the literature describing the synthesis of novel benzodiazepine analogues[31], and emphasis is placed on the alteration and replacement of benzene ring with a
Other Beilstein-Institut Open Science Activities
