Search results
Search for "cancer treatment" in Full Text gives 33 result(s) in Beilstein Journal of Organic Chemistry.
Probing multivalency in ligand–receptor-mediated adhesion of soft, biomimetic interfaces
Beilstein J. Org. Chem. 2015, 11, 720–729, doi:10.3762/bjoc.11.82
- to identify the key principles of carbohydrate/protein receptor interaction and to utilize carbohydrate structures as drugs, e.g., in cancer treatment or pathogen-related diseases [2][3]. A well-established key principle of carbohydrate–receptor interactions is multivalency. Natural carbohydrate
Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin
Beilstein J. Org. Chem. 2015, 11, 204–212, doi:10.3762/bjoc.11.22
- cancer treatment since nanocapsules would accumulate within the tumour tissue and release the drug in a sustained manner over time [38]. In addition, anionic CD nanocapsules released CPT slightly faster than chitosan-coated cationic CD nanocapsules. Faster release of CPT from anionic nanocapsules can be
Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers
Beilstein J. Org. Chem. 2015, 11, 147–154, doi:10.3762/bjoc.11.14
- as nanoparticles and micelles. Recently, the first delivery of siRNA in humans using CD polymers was reported [14] and currently two drug-delivery systems based on CD polymers have entered clinical phase II trials in cancer treatment [6]. The advantages of CD polymers can be exploited in preparation
Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids
Beilstein J. Org. Chem. 2014, 10, 1017–1022, doi:10.3762/bjoc.10.101
- ]. Depsipeptides are polymeric natural compounds, analogues of peptides, being formed by amino acids and hydroxy acids linked together by amide and ester bonds. These natural products show promising biological activities, especially regarding their therapeutic potential in cancer treatment [19]. An example of a
Polymeric redox-responsive delivery systems bearing ammonium salts cross-linked via disulfides
Beilstein J. Org. Chem. 2013, 9, 1652–1662, doi:10.3762/bjoc.9.189
- of DNA encapsulation used in anti-cancer treatment [16][17][18][19][20][21][22][23]. Further examples for polymeric networks based on poly(ethylenimine) (PEI) or poly(diethyl acrylamide) (PDEA) can be found in the literature [24][25][26]. Disulfide bonds are generally stable in human blood
An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells
Beilstein J. Org. Chem. 2012, 8, 787–803, doi:10.3762/bjoc.8.89
- endothelia of tumor tissues and, thus, represent ideal targets for cancer treatment. In this respect, GSF may occupy the same binding site on these integrins as the cyclic RGD pentapeptide Cilengitide®, which targets the integrins ανβ3 and α5β1. Cilengitide has been described as a strong inhibitor of
Palladium- and copper-mediated N-aryl bond formation reactions for the synthesis of biological active compounds
Beilstein J. Org. Chem. 2011, 7, 59–74, doi:10.3762/bjoc.7.10
- biologically active compounds are reblastatin (68) and autolytimycin (69). These potent inhibitors of heat shock protein 90, an important therapeutic target for cancer treatment, were accessed by a copper-mediated macrocyclization step of 70 to 71 in high yield (82%, Scheme 16) [67]. The same method was
Mitomycins syntheses: a recent update
Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33
- alkylation and cross-linking. The success of mitomycin C in cancer treatment is due to a great cytotoxic selectivity for hypoxic (O2-deficient) cells characteristic of solid tumors [33][34]. Mitomycin C itself is indeed relatively unreactive toward DNA [35][36] but becomes remarkably reactive upon reduction
Other Beilstein-Institut Open Science Activities
