Learning from the unexpected in life and DNA self-assembly

• Jennifer M. Heemstra

Beilstein J. Org. Chem. 2015, 11, 2713–2720, doi:10.3762/bjoc.11.292

• demonstrated that we could use our split aptamer ligation method to measure the concentration of a small-molecule target, but doing so required analysis via gel electrophoresis. Thus, we sought to create an assay that would be capable of the high throughput needed for clinical diagnostics applications, and we

Impact of multivalent charge presentation on peptide–nanoparticle aggregation

• Daniel Schöne,
• Boris Schade,
• Christoph Böttcher and
• Beate Koksch

Beilstein J. Org. Chem. 2015, 11, 792–803, doi:10.3762/bjoc.11.89

• controlled assembly of nanoparticles by means of biomolecules is crucial for biological and medical applications such as sensing [4], bioimaging [5], and medical diagnostics [6]. Although nanoparticles are also applied as targeted biomarkers and drug-delivery agents to tumor cells [7], only very little is

Detonation nanodiamonds biofunctionalization and immobilization to titanium alloy surfaces as first steps towards medical application

• Juliana P. L. Gonçalves,
• Afnan Q. Shaikh,
• Manuela Reitzig,
• Daria A. Kovalenko,
• Jan Michael,
• René Beutner,
• Gianaurelio Cuniberti,
• Dieter Scharnweber and
• Jörg Opitz

Beilstein J. Org. Chem. 2014, 10, 2765–2773, doi:10.3762/bjoc.10.293

• Juliana P. L. Goncalves Afnan Q. Shaikh Manuela Reitzig Daria A. Kovalenko Jan Michael Rene Beutner Gianaurelio Cuniberti Dieter Scharnweber Jorg Opitz Inspection and Diagnosis Methods, Fraunhofer Institute for Ceramic Technologies and Systems –Materials Diagnostics, Maria-Reiche-Str. 2, 01109

Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier

• Yamei Zhao,
• Wei Tian,
• Guang Yang and
• Xiaodong Fan

Beilstein J. Org. Chem. 2014, 10, 2696–2703, doi:10.3762/bjoc.10.284

• ; hyperbranched polymer; multifunctionality; polymer nanocarrier; Introduction In recent years, many nanostructured materials (such as polymeric micelles) used as pharmaceutical nanocarriers have been applied in different fields of biomedicine for controlled release, diagnostics, imaging, treatment and

Multivalent glycosystems for nanoscience

• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2014, 10, 2345–2347, doi:10.3762/bjoc.10.244

• can target specific tissues. Indeed, they will certainly find applications in materials science and in medicine, for example, in drug delivery or diagnostics [36]. Consequently, this COST Action (CM1102) [37] was called “MultiGlycoNano” to illustrate that multivalent glycostructures now enter the era

Indium-mediated allylation in carbohydrate synthesis: A short and efficient approach towards higher 2-acetamido-2-deoxy sugars

• Christopher Albler,
• Ralph Hollaus,
• Hanspeter Kählig and
• Walther Schmid

Beilstein J. Org. Chem. 2014, 10, 2230–2234, doi:10.3762/bjoc.10.231

• chemistry as tracers for tumor detection, myocardial ischemia or infarct diagnostics [10]. The group of Perez et al has taken a particular interest in the chemistry of 2-aminoheptoses [11][12][13][14] which they prepared via an amino-nitrile synthesis [15]. This method, first described by Kuhn and

Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA₂DNA triplexes

• Alex Manicardi,
• Lucia Guidi,
• Alice Ghidini and
• Roberto Corradini

Beilstein J. Org. Chem. 2014, 10, 1495–1503, doi:10.3762/bjoc.10.154

• the fluorescence properties can be observed upon interaction with DNA, thus enabling to study the occurring interactions and to produce switching PNA probes. Fluorescent switching probes for DNA detection are very useful tools in diagnostics applications such as real-time PCR and in situ hybridisation

• objective of stabilizing triplexes even in the presence of pyrimidines on the target sequence, while still maintaining and even increasing sequence selectivity. Moreover, for diagnostics, it is important that a very high and sequence-selective excimer to monomer ratio can be obtained, as with PNA2, upon

Molecular recognition of surface-immobilized carbohydrates by a synthetic lectin

• Melanie Rauschenberg,
• Eva-Corrina Fritz,
• Christian Schulz,
• Tobias Kaufmann and
• Bart Jan Ravoo

Beilstein J. Org. Chem. 2014, 10, 1354–1364, doi:10.3762/bjoc.10.138

• as drugs in various therapies and as recognition units in diagnostics and sensing. However, the development of synthetic lectins poses a phenomenal challenge for supramolecular chemistry [37] because a carbohydrate receptor in order to be useful must not only compete with the strong hydration of

Synthesis of fluorescent (benzyloxycarbonylamino)(aryl)methylphosphonates

• Michał Górny vel Górniak,
• Anna Czernicka,
• Piotr Młynarz,
• Waldemar Balcerzak and
• Paweł Kafarski

Beilstein J. Org. Chem. 2014, 10, 741–745, doi:10.3762/bjoc.10.68

• for profiling the proteolytic secretomes with the obtained profiles being useful as diagnostic tools [6][7][8]. Also conjugates of drugs with fluorescent probes have been used as so called theranostics (combination of therapeutics and diagnostics) [9][10]. Diaryl esters of α-aminoalkanephosphonic

SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression

• Silke Felix,
• Louis P. Sandjo,
• Till Opatz and
• Gerhard Erkel

Beilstein J. Org. Chem. 2013, 9, 2866–2876, doi:10.3762/bjoc.9.323

• Diagnostics, Mannheim, Germany)). 25 µg total cell extracts were subjected to 10% SDS-PAGE, transferred onto a nitrocellulose membrane, probed with antibodies specific for human survivin (1:1000, 71G4B7, New England Biolabs Frankfurt/M) or β-actin (1:1000, 13E5, New England Biolabs Frankfurt/M) and then with

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

• Todd J. Eckroat,
• Abdelrahman S. Mayhoub and
• Sylvie Garneau-Tsodikova

Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116

• a significant and increasing burden on our population, and efforts towards the development of new and improved diagnostics and therapeutics for this devastating disease are important research endeavors. Several pathological hallmarks of AD have been identified, and they include decreased cholinergic

Methylidynetrisphosphonates: Promising C₁ building block for the design of phosphate mimetics

• Vadim D. Romanenko and
• Valery P. Kukhar

Beilstein J. Org. Chem. 2013, 9, 991–1001, doi:10.3762/bjoc.9.114

• of the lupine enzyme. Since the detection of levels of Fhit protein is an important problem relating to cancers, Fhit-selective inhibitors such as 47 and 48 can be valuable as Fhit diagnostics [8]. β,γ-Chlorophosphonomethylene–ATP, AdoPPCCl(P)P, is a weak antagonist at P2X2/3 receptors (IC50 about 10

Ring opening of 2-aza-3-borabicyclo[2.2.0]hex-5-ene, the Dewar form of 1,2-dihydro-1,2-azaborine: stepwise versus concerted mechanisms

• Holger F. Bettinger and
• Otto Hauler

Beilstein J. Org. Chem. 2013, 9, 761–766, doi:10.3762/bjoc.9.86

• ) treatment should produce highly reliable results. Only for TS4 and TS6 are the T1 diagnostics 0.024 and 0.023, respectively. To confirm that the single reference CCSD(T) treatment produces satisfactory results also for these stationary points, we have computed the completely renormalised CR-CCSD(T)L

• energies for all species, as CR-CCSD(T)L has been shown to dramatically improve CCSD(T) results of multireference cases. The CR-CCSD(T)L energies are within 0.2 kcal mol−1 of the CCSD(T) values for all these species, including those (TS4 and TS6) with slightly elevated T1 diagnostics. Comparison of the

Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

• Friederike I. Nollmann,
• Andrea Dowling,
• Marcel Kaiser,
• Klaus Deckmann,
• Sabine Grösch,
• Richard ffrench-Constant and
• Helge B. Bode

Beilstein J. Org. Chem. 2012, 8, 528–533, doi:10.3762/bjoc.8.60

• ; Roche Diagnostics, Germany) was used to determine the cell viability after treatment of cells with the compounds. HeLa cells were seeded at a density of 3 × 103 cells in 100 µL culture medium containing 10% FCS into 96-well microplates and incubated for 24 h at 37 °C. The medium was removed and HeLa

Cross-metathesis of allylcarboranes with O-allylcyclodextrins

• Ivan Šnajdr,
• Zbyněk Janoušek,
• Jindřich Jindřich and
• Martin Kotora

Beilstein J. Org. Chem. 2010, 6, 1099–1105, doi:10.3762/bjoc.6.126

• the best of our knowledge, described. Since carboranes are of potential interest for various applications in medicine (e.g. boron neutron capture therapy for cancer, radionuclide diagnostics and therapy, and related fields [14][15][16][17], whilst some carboranes possess antiviral activity [18][19

RAFT polymers for protein recognition

• Alan F. Tominey,
• Julia Liese,
• Sun Wei,
• Klaus Kowski,
• Thomas Schrader and
• Arno Kraft

Beilstein J. Org. Chem. 2010, 6, No. 66, doi:10.3762/bjoc.6.66

• protein enrichment and purification, sensing and diagnostics applications, as well as therapeutic uses involving interference with critical protein–protein interactions. Multivalency represents the key to generate high-affinity materials for biomacromolecules with a sufficient number of binding sites for