Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

• Haijun Qu,
• Xuejian Li,
• Fan Mo and
• Xufeng Lin

Beilstein J. Org. Chem. 2013, 9, 2846–2851, doi:10.3762/bjoc.9.320

• developed a novel class of spirocyclic SPINOL-phosphoric acids derived from chiral 1,1'-spirobiindane-7,7'-diol, which could effectively catalyze some highly enantioselective reactions [25][26][27][28][29][30][31]. These previous successes led us to envision that SPINOL-phosphoric acids would effectively

Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step

• James C. Anderson,
• Andreas S. Kalogirou,
• Michael J. Porter and
• Graham J. Tizzard

Beilstein J. Org. Chem. 2013, 9, 1737–1744, doi:10.3762/bjoc.9.200

• . Enantioselective reactions have been controlled by asymmetric metal-centred Lewis acids; chiral hydrogen bond donors, in particular by the use of asymmetric thiourea organocatalysts, chiral Brønsted acids, phase-transfer catalysts and Brønsted base catalysts [3][15][25][26][27][28][29][30][31][32][33][34][35][36

Reactions of salicylaldehyde and enolates or their equivalents: versatile synthetic routes to chromane derivatives

• Ishmael B. Masesane and
• Zelalem Yibralign Desta

Beilstein J. Org. Chem. 2012, 8, 2166–2175, doi:10.3762/bjoc.8.244

• conditions and are ideal for the synthesis of chromane derivatives due to their operational simplicity. The development of enantioselective reactions of salicylaldehyde and enolates to give nearly optically pure chromane derivatives is a memorable highlight of this review. Future work will undoubtedly focus

Synthesis and structure of tricarbonyl(η⁶-arene)chromium complexes of phenyl and benzyl D-glycopyranosides

• Thomas Ziegler and
• Ulrich Heber

Beilstein J. Org. Chem. 2012, 8, 1059–1070, doi:10.3762/bjoc.8.118

• for enantioselective reactions [6][7][8]. Despite the broad applications that tricarbonyl(η6-arene)chromium complexes have found in organic synthesis since their discovery in 1957, only a very few tricarbonylchromium complexes of sugar derivatives are known today. Figure 1 shows the types of such

Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids

• M. Isabel Burguete,
• Eduardo García-Verdugo and
• Santiago V. Luis

Beilstein J. Org. Chem. 2011, 7, 1347–1359, doi:10.3762/bjoc.7.159

• enantioselective reactions. In the examples shown, the activity, selectivity and enantioselectivity of the processes was modulated through the proper adjustment of the reaction parameters, such as pressure, temperature, flow, and the nature of the scF, etc., allowing for a rapid optimization of the process. An

Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• conditions and in the case of heterogeneous catalysis, potential long term use of the catalysts. This review will highlight some of the continuous flow asymmetric reactions described to date. Review Homogeneous catalysis Only a few examples of homogeneous enantioselective reactions in continuous flow have

The first salen- type ligands derived from 3',5'-diamino- 3',5'-dideoxythymidine and -dideoxyxylothymidine and their corresponding copper(II) complexes

• Daniel Koth,
• Michael Gottschaldt,
• Helmar Görls and
• Karolin Pohle

Beilstein J. Org. Chem. 2006, 2, No. 17, doi:10.1186/1860-5397-2-17

• as the replacement of the thymine base by different functional groups or the immobilization of the complexes by the nucleobase enables the resulting complexes to become promising candidates as catalysts for enantioselective reactions. Conclusion In summary, an effective route for the synthesis of 3