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Search for "enyne metathesis" in Full Text gives 26 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides

  • Satoru Arimitsu and
  • Gerald B. Hammond

Beilstein J. Org. Chem. 2010, 6, No. 48, doi:10.3762/bjoc.6.48

Graphical Abstract
  • difluorodihydropyridinones via a ring-closing metathesis reaction, and of 4,4-difluoro-3-oxoisoquinolines through a ring-closing metathesis–enyne metathesis tandem reaction. These products, in turn, undergo a Diels–Alder reaction to yield heterotricyclic systems in moderate to good yields. Keywords: bicyclic lactams
  •  tricyclic ring systems [20]. Results and Discussion Initially, we investigated the enyne metathesis reaction of fluorinated enyne 1a with commercially available ruthenium carbene complexes, the Hoveyda–Grubbs second-generation catalyst being the most reactive (entries 1–3, Table 1). The reaction at 110 °C
  • reaction time. The stereochemistry of 7a and 7b was determined by COSY and NOESY experiments. Recently, various tandem reactions with ruthenium complexes have become popular in organic chemistry because Ru(II) complexes are capable of catalyzing additional reactions [26][27]. Since our enyne metathesis
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Published 14 May 2010
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