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Search for "enzyme catalysis" in Full Text gives 35 result(s) in Beilstein Journal of Organic Chemistry.
Stereoselectively fluorinated N-heterocycles: a brief survey
Beilstein J. Org. Chem. 2013, 9, 2696–2708, doi:10.3762/bjoc.9.306
- Enzyme catalysis was presented earlier (Scheme 1) as a strategy for synthesising fluorinated β-lactams (4) [18]. At that time, we were interested in the effect that the fluorine substituents had on the reactivity of the β-lactam derivatives. However this work now merits further attention, because it also
Bidirectional cross metathesis and ring-closing metathesis/ring opening of a C2-symmetric building block: a strategy for the synthesis of decanolide natural products
Beilstein J. Org. Chem. 2013, 9, 2544–2555, doi:10.3762/bjoc.9.289
- carboxylic acid and (iii) a Ru–lipase-catalyzed dynamic kinetic resolution to establish the desired configuration at C9. Ring closure was accomplished by macrolactonization. Curvulide A was synthesized from stagonolide E through Sharpless epoxidation. Keywords: dienes; enzyme catalysis; lactones; metathesis
Chemoenzymatic synthesis and biological evaluation of enantiomerically enriched 1-(β-hydroxypropyl)imidazolium- and triazolium-based ionic liquids
Beilstein J. Org. Chem. 2013, 9, 516–525, doi:10.3762/bjoc.9.56
- or iodides, yielding novel optically active ionic liquids. Racemic salts were tested against a wide range of microorganisms. Keywords: antibiotics; antifungal agents; double derivatization; enzyme catalysis; ionic liquids; Introduction Aromatic heterocycles play a crucial role in medicinal
Asymmetric Diels–Alder reaction with >C=P– functionality of the 2-phosphaindolizine-η1-P-aluminium(O-menthoxy) dichloride complex: experimental and theoretical results
Beilstein J. Org. Chem. 2013, 9, 392–400, doi:10.3762/bjoc.9.40
- in enzyme catalysis [53]. However, in the present case, the entropy difference between the TS1 and TS3 is negligible and does not appear to play significant role. On the other hand, entropy effects favour the endo approach over the exo approach from the Si face. Although the three reactions are
Cyclodextrin-based nanosponges as drug carriers
Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235
- that has emerged from experiments on enzyme catalysis is the prolonged activity of the enzymes [26]. Nanosponges can preserve the activity of some enzymes far longer than other supporting media, such as agarose. Moreover, the possibility of including enzymes inside the structure prolongs their activity
Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system
Beilstein J. Org. Chem. 2012, 8, 539–550, doi:10.3762/bjoc.8.62
- life's supramolecular systems in which the guest molecule (e.g., amino acids, neurotransmitters, drugs) is selectively captured into the host macromolecular structure (molecular recognition) and transformed catalytically at a specific “active site” (enzyme catalysis) [1][2][3]. Furthermore, the
Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases
Beilstein J. Org. Chem. 2011, 7, 1643–1647, doi:10.3762/bjoc.7.193
- demonstrates a remarkable potential of non-heme iron(II) oxygenases to oxidize substrates selectively at sterically hindered positions. Keywords: asymmetric catalysis; enzyme catalysis; hydroxyproline; α-ketoglutarate dependent iron(II) oxygenases; regioselectivity; stereoselectivity; Findings
A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: Important synthons for the synthesis of chromogenic/fluorogenic protease substrates
Beilstein J. Org. Chem. 2011, 7, 1030–1035, doi:10.3762/bjoc.7.117
- acid/peptide conjugates liberates the free chromophore or fluorophore, allowing the convenient determination of the rate of enzyme catalysis with a UV or fluorescence spectrophotometer. p-Nitroaniline (pNA) is one of the most commonly used chromogenic reagents. The synthesis of peptide-pNAs usually
Catalysis: transition-state molecular recognition?
Beilstein J. Org. Chem. 2010, 6, 1026–1034, doi:10.3762/bjoc.6.117
- wasted catalytic power (Figure 1), but also that the particularities of any events occurring along paths between reactants and TS (termed as the “microhistory” of the reaction [7]) are irrelevant to the catalysis itself. Theories within the “canon” of enzyme catalysis tend to omit or at least de
- treatment [6]: “A complete understanding of enzyme catalysis … resolves into a characterisation of two binding processes: that for the transition state, which yields a model for catalysis, and that for the reactant state, which yields a model for … inhibitory effects … The differential stabilisation of the
- importance for enzyme catalysis of destabilisation as well as binding has also been noted by Jencks [14]. Some years ago I performed an ab initio Hartree–Fock investigation [15], intended to test the validity of the compression hypothesis; this exercise amounted to the computational design of a catalyst for
N-acylation of ethanolamine using lipase: a chemoselective catalyst
Beilstein J. Org. Chem. 2009, 5, No. 10, doi:10.3762/bjoc.5.10
- lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and
- microwave irradiation. Keywords: chemoselective; lipase; microwave irradiation; zein number; Introduction Microwave assisted enzyme catalysis is a popular developing methodology in the field of green chemistry [1]. Enzymes have gained pivotal importance in the production of fine chemicals, pharmaceuticals
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