A small azide-modified thiazole-based reporter molecule for fluorescence and mass spectrometric detection

• Stefanie Wolfram,
• Hendryk Würfel,
• Stefanie H. Habenicht,
• Christine Lembke,
• Phillipp Richter,
• Eckhard Birckner,
• Rainer Beckert and
• Georg Pohnert

Beilstein J. Org. Chem. 2014, 10, 2470–2479, doi:10.3762/bjoc.10.258

• BPT (1). BPT (1) is thus transformed efficiently in the CuAAC reaction and the products such as 11 can be detected with high sensitivity using LC–MS. Besides the coupling product of BPT (11) only the low fluorescent 14 shows unique isotopic patterns caused by the two isotopes 79Br and 81Br. This

[²H₂₆]-1-epi-Cubenol, a completely deuterated natural product from Streptomyces griseus

• Christian A. Citron and
• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2013, 9, 2841–2845, doi:10.3762/bjoc.9.319

• full structure of the natural product [6]. A drawback is the health risk emanating from radioactively labelled compounds, thus requiring high safety standards in their handling. Feeding experiments are today in most cases performed with stable isotopes [7]. For 13C-labelled compounds the locus of

A study on electrospray mass spectrometry of fullerenol C₆₀(OH)₂₄

• Mihaela Silion,
• Andrei Dascalu,
• Mariana Pinteala,
• Bogdan C. Simionescu and
• Cezar Ungurenasu

Beilstein J. Org. Chem. 2013, 9, 1285–1295, doi:10.3762/bjoc.9.145

• provided by the manufacturer. Data were collected and processed by using MassHunter workstation data acquisition software for the 6200/6500 series, version B.01.03. The calculated m/z values are based on the weight of the most abundant isotopes (monoisotopic mass). The key experimental observations The

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

• Todd J. Eckroat,
• Abdelrahman S. Mayhoub and
• Sylvie Garneau-Tsodikova

Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116

• with the localization and residence time necessary for imaging, technetium-99m [99mTc] is also a radionuclide of choice that is easily produced by a 99Mo/99mTc generator [12]. Iodine isotopes such as [125I] are also employed, although much less frequently [13]. The general synthetic methods utilized to

Spin state switching in iron coordination compounds

• Philipp Gütlich,
• Ana B. Gaspar and
• Yann Garcia

Beilstein J. Org. Chem. 2013, 9, 342–391, doi:10.3762/bjoc.9.39

• isotopes that have not been accessible with conventional Mössbauer spectroscopy can be used. NIS allows the investigation of vibrational modes and the partial density of states (PDOS) locally, i.e., in the close neighborhood of the Mössbauer probe nucleus. Compared, for instance, to Raman spectroscopy, NIS

Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

• Evan F. Haney,
• Leonard T. Nguyen,
• David J. Schibli and
• Hans J. Vogel

Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

• -α-phosphatidylethanolamine (ePE), egg-derived L-α-phosphatidylglycerol (ePG) and cholesterol were purchased from Avanti Polar Lipids, Inc. (Alabaster, AL). Deuterated methanol used in the NMR samples was obtained from Cambridge Isotopes Laboratories, Inc. (Andover, MA). Deuterated chloroform (CDCl3