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Search for "mitochondria" in Full Text gives 36 result(s) in Beilstein Journal of Organic Chemistry.
Derivatives of the triaminoguanidinium ion, 5. Acylation of triaminoguanidines leading to symmetrical tris(acylamino)guanidines and mesoionic 1,2,4-triazolium-3-aminides
Beilstein J. Org. Chem. 2017, 13, 579–588, doi:10.3762/bjoc.13.57
- biological activities have been reported for some of the other types of mesoionic heterocycles. For example, antitumor [27][28][29], antileishmanial [30] and trypanocidal [31] activities, as well as reduction of the phosphorylation efficiency of rat liver mitochondria [32], have been described for 1,3,4
Synthesis of spiro[isoindole-1,5’-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction
Beilstein J. Org. Chem. 2016, 12, 2793–2807, doi:10.3762/bjoc.12.278
- the damage is repaired. If the damage is too severe, p53 trigs apoptosis which allows the elimination of damaged cells, also by its translocation in the mitochondria where it inhibits the activity of anti-apoptotic proteins. Many tumors overproduce MDM2 to impair p53 function, thus promoting
Antibiotics from predatory bacteria
Beilstein J. Org. Chem. 2016, 12, 594–607, doi:10.3762/bjoc.12.58
- respiratory chain. They were shown to block the electron flow at complex I of mitochondria (NADH:ubiquinone oxidoreductase) in a competitive manner, but do not act on bacterial complex I [71][72]. This explains why the myxalamids are mainly active against fungi [71]. The myxovirescins comprise a family of
Biosynthesis of α-pyrones
Beilstein J. Org. Chem. 2016, 12, 571–588, doi:10.3762/bjoc.12.56
- and the pathways triggered by 17, the induction of an apoptotic process was revealed. Further investigations showed that cell death was mediated through a mitochondria-dependent pathway [24]. In murine hepatoma cells it was shown that 17 and its methyl ether 19 interfere with the transcription factor
Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach
Beilstein J. Org. Chem. 2015, 11, 25–30, doi:10.3762/bjoc.11.4
- can be of peptidic origin [2][3]. As an example, Harran and co-workers synthesized a low-molecular weight C2-symmetric 1,3-diyne-linked peptide 1 which was able to mimic the function of Smac (second mitochondria-derived activator of caspase) protein by triggering caspase 8 activation as well as
Molecular recognition of AT-DNA sequences by the induced CD pattern of dibenzotetraaza[14]annulene (DBTAA)–adenine derivatives
Beilstein J. Org. Chem. 2014, 10, 2175–2185, doi:10.3762/bjoc.10.225
- phosphonium substituents as intriguing AT binders, which showed very rare kinetic differentiation between alternating- and homo-AT-DNA sequences [6]. Moreover, these dyes efficiently entered cells and were shown to be non-toxic, mitochondria-specific fluorescent markers [7]. Previous studies also revealed the
Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues
Beilstein J. Org. Chem. 2014, 10, 155–162, doi:10.3762/bjoc.10.13
- has been performed using the sequence of the Ugi multicomponent reaction and Cu(I)-catalyzed click chemistry. The effect of obtained γ-carboline–peptide conjugates on the rat liver mitochondria was evaluated. It was found that all compounds in the concentration of 30 µM did onot induce depolarization
- of mitochondria but possessed some inhibitory effect on the mitochondria permeability transition. The original N-substituted-tetrahydro-γ-carbolines containing an terminal alkyne group demonstrated a high prooxidant activity, whereas their conjugates with peptide fragments slightly inhibited both
- diseases [1][2][3]. Thus, one of the specific symptoms of such pathologies is a decrease in the ability of mitochondria to regulate the calcium homeostasis in cells and malfunction of mitochondrial permeability transition (MPT) that represents a key step in the cascades of cell death. From this point of
The regulation and biosynthesis of antimycins
Beilstein J. Org. Chem. 2013, 9, 2556–2563, doi:10.3762/bjoc.9.290
- reductase, an enzyme in the electron transport chain in mitochondria and bacteria and as such they are bioactive against a wide range of oragnisms including fish, fungi, insects and nematodes [24]. Antimycins are widely used as a piscicide (brandname Fintrol) in the catfish farming industry. Catfish are
Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues
Beilstein J. Org. Chem. 2013, 9, 1551–1558, doi:10.3762/bjoc.9.176
- mitochondrial membrane potential (MMP). Human U-2 OS osteosarcoma cells were treated for 16 hours with aurachins 4, 9–11, and 17–19 at concentrations between 1 and 10 µg/mL, and mitochondria were labeled with tetramethylrhodamine methyl ester (TMRM) in order to assess changes in MMP (Figure 2). Most prominent
Hydrophobic analogues of rhodamine B and rhodamine 101: potent fluorescent probes of mitochondria in living C. elegans
Beilstein J. Org. Chem. 2012, 8, 2156–2165, doi:10.3762/bjoc.8.243
- Mitochondria undergo dynamic fusion and fission events that affect the structure and function of these critical energy-producing cellular organelles. Defects in these dynamic processes have been implicated in a wide range of human diseases including ischemia, neurodegeneration, metabolic disease, and cancer
- . To provide new tools for imaging of mitochondria in vivo, we synthesized novel hydrophobic analogues of the red fluorescent dyes rhodamine B and rhodamine 101 that replace the carboxylate with a methyl group. Compared to the parent compounds, methyl analogues termed HRB and HR101 exhibit slightly red
- tissues by confocal laser scanning microscopy after treatment for 2 h at concentrations as low as 100 picomolar. Because transgenes are poorly expressed in the germline of these animals, these small molecules represent superior tools for labeling dynamic mitochondria in this tissue compared with the
Recent progress on the total synthesis of acetogenins from Annonaceae
Beilstein J. Org. Chem. 2008, 4, No. 48, doi:10.3762/bjoc.4.48
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