Directed ortho,ortho'-dimetalation of hydrobenzoin: Rapid access to hydrobenzoin derivatives useful for asymmetric synthesis

• Inhee Cho,
• Labros Meimetis,
• Lee Belding,
• Michael J. Katz,
• Travis Dudding and
• Robert Britton

Beilstein J. Org. Chem. 2011, 7, 1315–1322, doi:10.3762/bjoc.7.154

• addition of organolithium reagents to arene tricarbonylchromium complexes [7] and α,β-unsaturated aldimines [8]. Notably, derivatives of hydrobenzoin in which the aromatic rings have been functionalized in the ortho and ortho' positions often display improved diastereo- or enantioselectivity over the

Meta-metallation of N,N-dimethylaniline: Contrasting direct sodium-mediated zincation with indirect sodiation-dialkylzinc co-complexation

• David R. Armstrong,
• Liam Balloch,
• Eva Hevia,
• Alan R. Kennedy,
• Robert E. Mulvey,
• Charles T. O'Hara and
• Stuart D. Robertson

Beilstein J. Org. Chem. 2011, 7, 1234–1248, doi:10.3762/bjoc.7.144

• capable of selectively abstracting hydrogen from organic substrates continues. Routinely, organolithium reagents have been employed for this purpose with the high electropositivity of lithium affording polar, reactive Cδ−–Liδ+ bonds proficient in metallating C–H bonds in organic, especially aromatic and

α,β-Aziridinylphosphonates by lithium amide-induced phosphonyl migration from nitrogen to carbon in terminal aziridines

• David. M. Hodgson and
• Zhaoqing Xu

Beilstein J. Org. Chem. 2010, 6, 978–983, doi:10.3762/bjoc.6.110

• substrate 1a (57%, Scheme 4) [28]. Initially, we examined organolithiums for their propensity to induce deprotonation-migration in N-phosphonate aziridine 1a. Despite it being previously noted by Zwierzak that the reaction of organolithium reagents with such substrates resulted in preferential attack at

Aromatic and heterocyclic perfluoroalkyl sulfides. Methods of preparation

• Vladimir N. Boiko

Beilstein J. Org. Chem. 2010, 6, 880–921, doi:10.3762/bjoc.6.88

An exceptional P-H phosphonite: Biphenyl- 2,2'-bisfenchylchlorophosphite and derived ligands (BIFOPs) in enantioselective copper- catalyzed 1,4-additions

• T. Kop-Weiershausen,
• J. Lex,
• J.-M. Neudörfl and
• B. Goldfuss

Beilstein J. Org. Chem. 2005, 1, No. 6, doi:10.1186/1860-5397-1-6

• recently applied in chiral organolithium reagents [52][53][54][55][56][57][58] and in organozinc [59][60][61][62] as well as in organopalladium catalysts [63][64][65][66][67] to study origins of enantioselectivities in C-C-couplings. The rigid, terpene-based bicyclo[2.2.1]heptane unit enables efficient