Multicomponent reactions in nucleoside chemistry

• Mariola Koszytkowska-Stawińska and
• Włodzimierz Buchowicz

Beilstein J. Org. Chem. 2014, 10, 1706–1732, doi:10.3762/bjoc.10.179

• reported reaction sequence. Ghosh and Kass synthesized nucleosides 119 from 2,3-dihydrofurane 117, ethyl pyruvate, and the silylated nucleobase 118 (Scheme 49) [126]. This method does not strictly comply with the Ugi’s definition of MCRs because of the sequential addition of the substrates. However, in our

Synthesis of homo- and heteromultivalent carbohydrate-functionalized oligo(amidoamines) using novel glyco-building blocks

• Felix Wojcik,
• Sinaida Lel,
• Alexander G. O’Brien,
• Peter H. Seeberger and
• Laura Hartmann

Beilstein J. Org. Chem. 2013, 9, 2395–2403, doi:10.3762/bjoc.9.276

• branched) [18] and biocompatible with a decreased risk of inherent immunogenicity [19]. Recently, we showed that monodisperse, sequence-defined glycooligomers obtained by sequential addition of building blocks on solid support are valuable tools for tuning and understanding carbohydrate–lectin interactions

Development of an additive-controlled, SmI₂-mediated stereoselective sequence: Telescoped spirocyclisation, lactone reduction and Peterson elimination

• Brice Sautier,
• Karl D. Collins and
• David J. Procter

Beilstein J. Org. Chem. 2013, 9, 1443–1447, doi:10.3762/bjoc.9.163

• manuscript, we report studies on SmI2-mediated cyclisation and lactone reduction that culminate in a “telescoped” sequence, i.e., a sequence of steps carried out on a single reaction mixture by the sequential addition of various reagents. In the sequence, additives are used with SmI2 to “switch on

Construction of cyclic enones via gold-catalyzed oxygen transfer reactions

• Leping Liu,
• Bo Xu and
• Gerald B. Hammond

Beilstein J. Org. Chem. 2011, 7, 606–614, doi:10.3762/bjoc.7.71

• rearrangement of alkynyl arylaldehydes 13 to benzoxepinones 14 with good regioselectivity (Scheme 11) [47]. This transformation was effectively promoted by the addition of benzyl alcohol and the sequential addition of p-toluenesulfonic acid. However, in the absence of p-toluenesulfonic acid, benzyl ether 15 was

One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

• Jonathan P. Brand,
• Clara Chevalley and
• Jérôme Waser

Beilstein J. Org. Chem. 2011, 7, 565–569, doi:10.3762/bjoc.7.65

• . Importantly, this transformation did not require prior aniline protection and proceeded under mild conditions. This methodology represents the first example of the sequential addition of Au(III) and Au(I) catalysts for a one-pot process. Experimental General procedure for the synthesis of 2-alkynylanilines 2

CuCl-catalyzed aerobic oxidation of 2,3-allenols to 1,2-allenic ketones with 1:1 combination of phenanthroline and bipyridine as ligands

• Shuxu Gao,
• Yu Liu and
• Shengming Ma

Beilstein J. Org. Chem. 2011, 7, 396–403, doi:10.3762/bjoc.7.51

• was purged with air and refilled with oxygen (twice). Then 1.5 mL of dry toluene was added, the resulting mixture was stirred at rt for 0.5 h which was followed by the sequential addition of DBAD (14.0 mg, 0.06 mmol), 2-hexyl-1-butylbuta-2,3-dien-1-ol (63.8 mg, 0.3 mmol) and 1.5 mL of dry toluene

Synthesis and crossover reaction of TEMPO containing block copolymer via ROMP

• Olubummo Adekunle,
• Susanne Tanner and
• Wolfgang H. Binder

Beilstein J. Org. Chem. 2010, 6, No. 59, doi:10.3762/bjoc.6.59

• times. Block copolymer syntheses The synthesis of block copolymers (An-b-Tn) was carried out analogously to methods developed previously in our laboratory [14][16]. For example the synthesis of BCP-A50T50 was performed by sequential addition of monomers. Monomer A 7 (15 mg, 0.071 mmol) dissolved in 1 ml

Synthesis of densely functionalized enantiopure indolizidines by ring- closing metathesis (RCM) of hydroxylamines from carbohydrate- derived nitrones

• Marco Bonanni,
• Marco Marradi,
• Francesca Cardona,
• Stefano Cicchi and
• Andrea Goti

Beilstein J. Org. Chem. 2007, 3, No. 44, doi:10.1186/1860-5397-3-44

• methodology, several symmetrically α,α'-disubstituted hydroxylamines 1 were afforded. An alternative protocol for the synthesis of unsymmetrically α,α'-disubstituted hydroxylamines 3, resulting from the sequential addition of two different Grignard reagents, was also developed in a stepwise process, based on