Beilstein J. Org. Chem.2007,3, No. 38, doi:10.1186/1860-5397-3-38
(Figure 2). The latter is an indolizidine alkaloid that has received significant attention from the synthetic organic community in view of its potent biological activity as an α- and β-glycosidase inhibitor with promising anti-diabetic,[19] anti-cancer,[20] anti-viral [21] and anti-AIDS activity.[22] The
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Graphical Abstract
Scheme 1:
An example of a vinylogous Mukaiyama aldol in a natural product synthesis. Reagents and conditions:...
Beilstein J. Org. Chem.2005,1, No. 12, doi:10.1186/1860-5397-1-12
as diabetes, cancer and viral infections including AIDS. Thus, inhibition of intestinal α-glucosidases can be used to treat diabetes through the lowering of blood glucose levels, and α-glucosidase inhibitors are being marketed against type 2 (non-insulinodependent mellitus) diabetes (i.e.: Glyset® or