Synthesis of conformationally restricted glutamate and glutamine derivatives from carbonylation of orthopalladated phenylglycine derivatives

• Esteban P. Urriolabeitia,
• Eduardo Laga and
• Carlos Cativiela

Beilstein J. Org. Chem. 2012, 8, 1569–1575, doi:10.3762/bjoc.8.179

• -amino acids [11][12][13], due to the extraordinary interest in these delicate molecules as building blocks of peptides and proteins, and because of their relevant biological activity. In this context, we have recently reported C–H bond activation processes on a variety of arylglycines substituted at the

• mild reaction conditions (1 atm CO, 25 °C) and, mainly, because it occurs through C–H bond activation processes without the need to use prefunctionalized substrates. Typical aminocarbonylations catalysed by Pd usually start from the corresponding iodides or bromides, and require high CO pressures and

C2-Alkylation of N-pyrimidylindole with vinylsilane via cobalt-catalyzed C–H bond activation

• Zhenhua Ding and
• Naohiko Yoshikai

Beilstein J. Org. Chem. 2012, 8, 1536–1542, doi:10.3762/bjoc.8.174

Organocatalytic C–H activation reactions

• Subhas Chandra Pan

Beilstein J. Org. Chem. 2012, 8, 1374–1384, doi:10.3762/bjoc.8.159

• transformations will not be covered in this review. Review Organocatalytic sp3 C–H bond activation reactions Non-asymmetric variants tert-Amino effect: The “tert-amino effect” refers to the ring-closure reactions that proceed by redox processes for C–C and C–X bond formation within conjugated systems [7][8][9

• enantioselectivity for their reaction [25]. Organocatalytic sp2 C–H bond activation reactions The catalytic cross-coupling of arenes and aryl halides to construct biaryl compounds is an important area in synthetic organic chemistry. Transition-metal-catalyzed biaryl synthesis from unactivated arenes by C–H

Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes

• Yiwen Yang,
• Chunxiang Kuang,
• Hui Jin,
• Qing Yang and
• Zhongkui Zhang

Beilstein J. Org. Chem. 2011, 7, 1656–1662, doi:10.3762/bjoc.7.195

• moderate to excellent yields. 1,3-Diaryl-4-halo-1H-pyrazoles are found to be important intermediates that can easily be converted into 1,2,5-triaryl-substituted pyrazoles via Pd-catalyzed C–H bond activation. Keywords: C–H bond activation; cycloaddition; dihaloalkenes; pyrazole; sydnones; Introduction