Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica

• Lu Zou,
• Ruixiang Blake Zheng and
• Todd L. Lowary

Beilstein J. Org. Chem. 2012, 8, 1219–1226, doi:10.3762/bjoc.8.136

• ) TBDPSCl, imidazole, DMF, 78%; (b) BnBr, NaH, TBAI, 84%; (c) TBAF, THF, 83%; (d) CH3I, NaH, DMF, 87%; (e) HO-P(O)(OBn)2, NIS, AgOTf, CH2Cl2, 70%; (f) H2, Pd(OH)2–C, NaHCO3, CH3OH, 91%. Reagents and conditions: (a) Ag2O, CaSO4, CH3I, 52%; (b) Ac2O–HOAc–H2SO4, 70:30:1, 96%; (c) EtSH, BF3·OEt2, CH2Cl2, 75