Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.

• Celso Almeida,
• Stefan Kehraus,
• Miguel Prudêncio and
• Gabriele M. König

Beilstein J. Org. Chem. 2011, 7, 1636–1642, doi:10.3762/bjoc.7.192

• activity towards three cancer cell lines (NCI-H460, MCF7 and SF268). Marilone A and C (1, 3) showed weak antiproliferative activity with an average GI50 of 36.7 and 26.6 µM, respectively (see Supporting Information File 1). Marilone B (2) was assayed in a panel of 44 psychoactive receptors, including 11

Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents

• María Jiménez,
• Wei Zhu,
• Andreas Vogt,
• Billy W. Day and
• Dennis P. Curran

Beilstein J. Org. Chem. 2011, 7, 1372–1378, doi:10.3762/bjoc.7.161

• , PA 15260, USA Department of Pharmaceutical Sciences, School of Pharmacy, 3501 Terrace Street, University of Pittsburgh, Pittsburgh, PA 15261 USA 10.3762/bjoc.7.161 Abstract The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative activity against a variety of

• microtubule-stabilizing agents include taxanes, epothilones, and discodermolides, among others [3][4]. Dictyostatin (1a) is an exceptionally potent microtubule-stabilizing agent that has shown antiproliferative activity in a variety of human cancer cell lines in the low nanomolar range. Isolated first in 1994

Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

• Karunananda Bombuwala,
• Thomas Kinstle,
• Vladimir Popik,
• Sonal O. Uppal,
• James B. Olesen,
• Jose Viña and
• Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

• , for antiproliferative activity of paclitaxel and vinorelbine individually, but synergy with concentrations as low as 3 nM and 0.01 nM respectively [51]. Thus, differing model systems yielded results variously suggesting antagonistic, non-additive, or synergistic effects. However, there is evidence