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Search for "chemical structures" in Full Text gives 250 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

  • Yuan-Nan Yuan,
  • Jin-Qiang Li,
  • Hong-Bin Fang,
  • Shao-Jun Xing,
  • Yong-Ming Yan and
  • Yong-Xian Cheng

Beilstein J. Org. Chem. 2023, 19, 789–799, doi:10.3762/bjoc.19.59

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  • . In our studies of arthropods over the years, we have found that non-peptide small molecules play a significant role in chemical structures and biological activities [11][12][13][14][15][16]. In examining the chemical constituents of the millipede K. svenhedini, the focus was directed toward non
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Published 07 Jun 2023

Cassane diterpenoids with α-glucosidase inhibitory activity from the fruits of Pterolobium macropterum

  • Sarot Cheenpracha,
  • Ratchanaporn Chokchaisiri,
  • Lucksagoon Ganranoo,
  • Sareeya Bureekaew,
  • Thunwadee Limtharakul and
  • Surat Laphookhieo

Beilstein J. Org. Chem. 2023, 19, 658–665, doi:10.3762/bjoc.19.47

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  • percent inhibition of activity was calculated as (A0 − A1)/A0 × 100, where A0 is the absorbance of control, and A1 is the absorbance with the sample. Acarbose was used as a standard drug and all experiments were evaluated in triplicate. Chemical structures of 1-3 isolated from P. macropterum. Key 1H,1H
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Published 11 May 2023

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

  • Jorge de Lima Neto and
  • Paulo Henrique Menezes

Beilstein J. Org. Chem. 2023, 19, 399–427, doi:10.3762/bjoc.19.31

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  • elucidate the chemical structures of the isolated compounds [19]. 2 Synthesis 2.1 Biosynthetic pathway In the literature, there are two possible biosynthetic pathways for the formation of these compounds. The first one was proposed by Pettit and co-workers [16][17] based on tyrosine as the starting material
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Published 29 Mar 2023

Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors

  • Sedat Ünal,
  • Gamze Varan,
  • Juan M. Benito,
  • Yeşim Aktaş and
  • Erem Bilensoy

Beilstein J. Org. Chem. 2023, 19, 139–157, doi:10.3762/bjoc.19.14

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Published 13 Feb 2023

Preparation of β-cyclodextrin/polysaccharide foams using saponin

  • Max Petitjean and
  • José Ramón Isasi

Beilstein J. Org. Chem. 2023, 19, 78–88, doi:10.3762/bjoc.19.7

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  • ]. The aglycone part is composed of steroid and triterpene molecules [3]. Not only present in plants [4][5], saponins have also been discovered in marine animals, such as sea cucumbers [6] or starfish [7]. Chemical structures of this family are varied [1], so they will show different properties [8
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Published 24 Jan 2023

Inclusion complexes of the steroid hormones 17β-estradiol and progesterone with β- and γ-cyclodextrin hosts: syntheses, X-ray structures, thermal analyses and API solubility enhancements

  • Alexios I. Vicatos,
  • Zakiena Hoossen and
  • Mino R. Caira

Beilstein J. Org. Chem. 2022, 18, 1749–1762, doi:10.3762/bjoc.18.184

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  • atoms were included in the models. Thereafter, the structures were refined by full-matrix least-squares techniques with SHELXL-97 [53], implemented in the X-SEED [54] interface. Chemical structures of 17β-estradiol (top) and progesterone (bottom). The PXRD patterns of the β-CD·PRO complex produced via
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Published 22 Dec 2022

Using UHPLC–MS profiling for the discovery of new sponge-derived metabolites and anthelmintic screening of the NatureBank bromotyrosine library

  • Sasha Hayes,
  • Aya C. Taki,
  • Kah Yean Lum,
  • Joseph J. Byrne,
  • Merrick G. Ekins,
  • Robin B. Gasser and
  • Rohan A. Davis

Beilstein J. Org. Chem. 2022, 18, 1544–1552, doi:10.3762/bjoc.18.164

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  • . Chemical structures of 5-debromopurealidin H (1) and ianthesine E (2). Key COSY, HMBC and ROESY correlations for 5-debromopurealidin H (1). Chemical structures of the NatureBank bromotyrosine derivatives: psammaplysins F (3) and H (4), bastadins 4 (5), 8 (6) and 13 (7), aerothionin (8) and hexadellin A (9
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Published 15 Nov 2022

Ionic multiresonant thermally activated delayed fluorescence emitters for light emitting electrochemical cells

  • Merve Karaman,
  • Abhishek Kumar Gupta,
  • Subeesh Madayanad Suresh,
  • Tomas Matulaitis,
  • Lorenzo Mardegan,
  • Daniel Tordera,
  • Henk J. Bolink,
  • Sen Wu,
  • Stuart Warriner,
  • Ifor D. Samuel and
  • Eli Zysman-Colman

Beilstein J. Org. Chem. 2022, 18, 1311–1321, doi:10.3762/bjoc.18.136

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  • nm, ΦPL = 61%, τd = 242 μs, kRISC = 3.04 × 103 s−1, 1 wt % in mCP). Different strategies were explored to prepare LEECs based on DiKTa-OBuIm and DiKTa-DPA-OBuIm as emitters. The devices showed green and red emission, respectively. Chemical structures of (a) reported ionic TADF emitters for LEECs, (b
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Published 22 Sep 2022

Molecular diversity of the base-promoted reaction of phenacylmalononitriles with dialkyl but-2-ynedioates

  • Hui Zheng,
  • Ying Han,
  • Jing Sun and
  • Chao-Guo Yan

Beilstein J. Org. Chem. 2022, 18, 991–998, doi:10.3762/bjoc.18.99

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  • in the reaction. Because there is only one chiral carbon atom in the molecule, there are no diastereoisomers in the obtained products 3a–l. The chemical structures of compounds 3a–l were fully characterized by IR, HRMS, 1H and 13C NMR spectra. As for an example, the 1H NMR spectrum of compound 3i
  • clearly indicated that only one diastereoisomer was actually produced in the reaction. The chemical structures of the compounds 4a–k were established by various spectroscopy methods. Additionally, the single crystal structures of compounds 4a and 4c were successfully determined (Figure 2 and Figure 3
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Published 08 Aug 2022

Anti-inflammatory aromadendrane- and cadinane-type sesquiterpenoids from the South China Sea sponge Acanthella cavernosa

  • Shou-Mao Shen,
  • Qing Yang,
  • Yi Zang,
  • Jia Li,
  • Xueting Liu and
  • Yue-Wei Guo

Beilstein J. Org. Chem. 2022, 18, 916–925, doi:10.3762/bjoc.18.91

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  • following the manufacturer’s instructions. β-ACTIN was used as the normalization control. All reactions were performed in triplicate. The NF-κB inhibitor Bay 11-7082 (5 μM) was used as a positive control. Chemical structures of compounds 1–8. ORTEP drawing of 2 (displacement ellipsoids are drawn at the 50
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Published 25 Jul 2022

Efficient production of clerodane and ent-kaurane diterpenes through truncated artificial pathways in Escherichia coli

  • Fang-Ru Li,
  • Xiaoxu Lin,
  • Qian Yang,
  • Ning-Hua Tan and
  • Liao-Bin Dong

Beilstein J. Org. Chem. 2022, 18, 881–888, doi:10.3762/bjoc.18.89

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  • ), have attracted great attention from chemists and biologists due to their intriguing chemical structures and broad pharmacological functions [1][2][3][4]. The vast structural diversity of diterpenoids arise biosynthetically from the following two stages: i) diterpene synthase (DTS, also called diterpene
  • produced new peaks in the HPLC profiles after a 3-day fermentation. Larger scale (3 L) fermentations of DL10004 and DL10006 led to the isolation of 45 mg and 90 mg of terpentetriene and ent-kaurene, respectively, whose 1H and 13C NMR spectra supported their chemical structures (Figures S4–S7 in Supporting
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Published 21 Jul 2022

Post-synthesis from Lewis acid–base interaction: an alternative way to generate light and harvest triplet excitons

  • Hengjia Liu and
  • Guohua Xie

Beilstein J. Org. Chem. 2022, 18, 825–836, doi:10.3762/bjoc.18.83

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  • nitrogen-containing heterocycles, resulting in the change of energy levels and spectra. The following will illustrate Lewis acids used in the exploration of luminescent materials and mechanisms due to Lewis acid–base interactions. The chemical structures of some candidate Lewis acids are shown in Figure 1
  • ][32], e.g., organic thin-film transistors [45][46], organic photovoltaics [47], and chemical sensing [48]. Chemical structures of Lewis acid examples. Chemical structures of Lewis basic fluorescent polymer poly{2,5-pyridylene-co-1,4-[2,5-bis(2-ethylhexyloxy)]phenylene} 1 and D–A–D compound 2,5-bis((N
  • vapor-treated device and the macroscopic gradation emissive pattern of polymer films on a glass plate after treatment and excited by 365 nm UV light. Figure 4 was reproduced from [31] with permission from The Royal Society of Chemistry. This content is not subject to CC BY 4.0. Chemical structures of
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Published 12 Jul 2022

Terpenoids from Glechoma hederacea var. longituba and their biological activities

  • Dong Hyun Kim,
  • Song Lim Ham,
  • Zahra Khan,
  • Sun Yeou Kim,
  • Sang Un Choi,
  • Chung Sub Kim and
  • Kang Ro Lee

Beilstein J. Org. Chem. 2022, 18, 555–566, doi:10.3762/bjoc.18.58

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  • + probability using an Excel sheet [25]. Chemical structures of compounds 1–9. Structure elucidation of 1. (A) Key COSY, HMBC, and NOE correlations of 1. (B) Comparison of calculated ECD data of 1a and experimental ECD spectrum of 1. Structure elucidation of 2. (A) Key COSY, HMBC, and NOE correlations of 2. (B
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Published 17 May 2022

Comparative study of thermally activated delayed fluorescent properties of donor–acceptor and donor–acceptor–donor architectures based on phenoxazine and dibenzo[a,j]phenazine

  • Saika Izumi,
  • Prasannamani Govindharaj,
  • Anna Drewniak,
  • Paola Zimmermann Crocomo,
  • Satoshi Minakata,
  • Leonardo Evaristo de Sousa,
  • Piotr de Silva,
  • Przemyslaw Data and
  • Youhei Takeda

Beilstein J. Org. Chem. 2022, 18, 459–468, doi:10.3762/bjoc.18.48

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  • theoretical calculations, the role of the additional donor unit in the TADF mechanism is boosting the rISC process by balancing the singlet–triplet energy gap and spin–orbit coupling. The results showcased herein would allow for designing efficient TADF emitters more flexibly in the future. Chemical
  • structures of 1 and POZ-DBPHZ. Steady-state UV–vis absorption (Abs) and photoluminescence (PL) spectra of dilute solutions (c ≈ 10−5 M) of compound 1. The PL spectra were acquired with λex = 340 nm for the cyclohexane solution and λex = 360 nm for solutions in the other solvents. Time-resolved PL decay
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Published 25 Apr 2022

Menadione: a platform and a target to valuable compounds synthesis

  • Acácio S. de Souza,
  • Ruan Carlos B. Ribeiro,
  • Dora C. S. Costa,
  • Fernanda P. Pauli,
  • David R. Pinho,
  • Matheus G. de Moraes,
  • Fernando de C. da Silva,
  • Luana da S. M. Forezi and
  • Vitor F. Ferreira

Beilstein J. Org. Chem. 2022, 18, 381–419, doi:10.3762/bjoc.18.43

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Published 11 Apr 2022

Amamistatins isolated from Nocardia altamirensis

  • Till Steinmetz,
  • Wolf Hiller and
  • Markus Nett

Beilstein J. Org. Chem. 2022, 18, 360–367, doi:10.3762/bjoc.18.40

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  • at 630 nm in a microplate reader. The values were plotted and the DC50 values were calculated. All tests were run in triplicate. Chemical structures of amamistatins (1–5) and a putative biosynthetic shunt product (6) isolated in this study. 1: R1 = CHO, R2 = H, R3 = H; 2: R1 = CHO, R2 = H, R3 = OH; 3
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Published 30 Mar 2022

Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity

  • Anna V. Korotina,
  • Svetlana G. Tolshchina,
  • Rashida I. Ishmetova,
  • Natalya P. Evstigneeva,
  • Natalya A. Gerasimova,
  • Natalya V. Zilberberg,
  • Nikolay V. Kungurov,
  • Gennady L. Rusinov,
  • Oleg N. Chupakhin and
  • Valery N. Charushin

Beilstein J. Org. Chem. 2022, 18, 243–250, doi:10.3762/bjoc.18.29

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  • been found. All the above-mentioned results demonstrate good prospects for finding new antifungal drugs in this class of compounds. X-ray structure of N-(6-(4-bromo-3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazin-3-yl)benzamide. Chemical structures of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine (a), [1,2,4
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Published 01 Mar 2022

Anomeric 1,2,3-triazole-linked sialic acid derivatives show selective inhibition towards a bacterial neuraminidase over a trypanosome trans-sialidase

  • Peterson de Andrade,
  • Sanaz Ahmadipour and
  • Robert A. Field

Beilstein J. Org. Chem. 2022, 18, 208–216, doi:10.3762/bjoc.18.24

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  • the deprotection step with CH3OH/triethylamine/H2O 4:1:5 [26], triethylammonium ions were exchanged upon treatment with Amberlite IR 120 (Na+ form) and compounds 3a–h were obtained in excellent yield and purity without further purification. Chemical structures and reported activities of viral (A
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Published 17 Feb 2022

Glycosylated coumarins, flavonoids, lignans and phenylpropanoids from Wikstroemia nutans and their biological activities

  • Meifang Wu,
  • Xiangdong Su,
  • Yichuang Wu,
  • Yuanjing Luo,
  • Ying Guo and
  • Yongbo Xue

Beilstein J. Org. Chem. 2022, 18, 200–207, doi:10.3762/bjoc.18.23

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  • large quantity of phenolic substances found in plants and microorganisms [5]. These naturally occurring coumarins were well documented due to their diverse chemical structures and promising biological properties, such as anticancer, antitubercular, anti-inflammatory, anticoagulant, antibacterial, and
  • ) at 35 °C with isocratic elution of 25% CH3CN in 0.1% H3PO4 for 40 min and subsequent washing of the column with 90% CH3CN at a flow rate 0.8 mL/min. Peaks at 16.54 and 19.64 min have coincided with derivatives of ᴅ-glucose and ᴅ-xylose [30]. Chemical structures of compounds 1–17 from W. nutans. The
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Published 16 Feb 2022

Mechanistic studies of the solvolysis of alkanesulfonyl and arenesulfonyl halides

  • Malcolm J. D’Souza and
  • Dennis N. Kevill

Beilstein J. Org. Chem. 2022, 18, 120–132, doi:10.3762/bjoc.18.13

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  • values are from [56] and [62]. Organic reactions where the breaking of a C–X bond involves the formation of a high energy ion-pair intermediate. The chemical structures for the 1-adamantyl substrate, 2-adamantyl substrate, and the S-methyldibenzothiophenium ion (MeDBTh+). In the 1- and 2-substituted
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Published 17 Jan 2022

Tenacibactins K–M, cytotoxic siderophores from a coral-associated gliding bacterium of the genus Tenacibaculum

  • Yasuhiro Igarashi,
  • Yiwei Ge,
  • Tao Zhou,
  • Amit Raj Sharma,
  • Enjuro Harunari,
  • Naoya Oku and
  • Agus Trianto

Beilstein J. Org. Chem. 2022, 18, 110–119, doi:10.3762/bjoc.18.12

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  • 50275, Central Java, Indonesia 10.3762/bjoc.18.12 Abstract HPLC/DAD-based chemical investigation of a coral-associated gliding bacterium of the genus Tenacibaculum yielded three desferrioxamine-class siderophores, designated tenacibactins K (1), L (2), and M (3). Their chemical structures, comprising
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Published 13 Jan 2022

Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units

  • Samet Poyraz,
  • Samet Belveren,
  • Sabriye Aydınoğlu,
  • Mahmut Ulger,
  • Abel de Cózar,
  • Maria de Gracia Retamosa,
  • Jose M. Sansano and
  • H. Ali Döndaş

Beilstein J. Org. Chem. 2021, 17, 2812–2821, doi:10.3762/bjoc.17.192

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  • cellular targets known for antituberculosis drugs and all the different chemical structures (inhibition of cell wall synthesis, disruption of the plasma membrane, DNA-gyrase, etc.) the next work focused on determining the exact biological mechanism and docking studies could not be executed. Conclusion The
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Published 02 Dec 2021

Adjusting the length of supramolecular polymer bottlebrushes by top-down approaches

  • Tobias Klein,
  • Franka V. Gruschwitz,
  • Maren T. Kuchenbrod,
  • Ivo Nischang,
  • Stephanie Hoeppener and
  • Johannes C. Brendel

Beilstein J. Org. Chem. 2021, 17, 2621–2628, doi:10.3762/bjoc.17.175

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  • obtain some control over the length distributions of 1D polymer nanostructures, and thus this makes them more likely to be applied in biomedicine, where dimensional control is a prerequisite. Schematic representation of the chemical structures of BTU and BTP and the supramolecular self-assembly of the
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Published 21 Oct 2021

Synthesis and investigation on optical and electrochemical properties of 2,4-diaryl-9-chloro-5,6,7,8-tetrahydroacridines

  • Najeh Tka,
  • Mohamed Adnene Hadj Ayed,
  • Mourad Ben Braiek,
  • Mahjoub Jabli and
  • Peter Langer

Beilstein J. Org. Chem. 2021, 17, 2450–2461, doi:10.3762/bjoc.17.162

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  • further study the electronic properties, DFT calculations were carried out on the fully ground state at the restricted B3LYPlevel with 6-31G(d) basis set using dichloromethane as a continuum solvent model. The optimized chemical structures of 4a–d are given in Figure 7 with selected geometrical parameters
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Published 20 Sep 2021

Efficient synthesis of polyfunctionalized carbazoles and pyrrolo[3,4-c]carbazoles via domino Diels–Alder reaction

  • Ren-Jie Fang,
  • Chen Yan,
  • Jing Sun,
  • Ying Han and
  • Chao-Guo Yan

Beilstein J. Org. Chem. 2021, 17, 2425–2432, doi:10.3762/bjoc.17.159

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  • chemical structures of the carbazoles were fully characterized by 1H NMR, 13C NMR, IR, and HRMS spectra. To explain the formation of the products, a plausible reaction mechanism was proposed in Scheme 2 on the basis of the previously reported reaction [48][53]. Firstly, the DDQ oxidative dehydrogenation of
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Published 16 Sep 2021
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