Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• Xiao Yin Mak Paola Laurino Peter H. Seeberger Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, D-14424 Potsdam, Germany 10.3762/bjoc.5.19 Abstract An overview of asymmetric synthesis in continuous flow and microreactors is presented in

• this review. Applications of homogeneous and heterogeneous asymmetric catalysis as well as biocatalysis in flow are discussed. Keywords: asymmetric catalysis; biocatalysis; continuous flow; microreactors; solid phase synthesis; Introduction While many technological advancements have been made over

• been reported, and these have been performed in microfluidic flow systems [10][11] consisting usually of micro-scale channels. The use of microreactors has been found to be especially useful for catalyst/ligand screening, as only low loading of reagents is required. The enantioselective silyl-cyanation

A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed- bed microreactor

• Andrew Bogdan and
• D. Tyler McQuade

Beilstein J. Org. Chem. 2009, 5, No. 17, doi:10.3762/bjoc.5.17

• 100 trials without showing any loss of catalytic activity. Keywords: alcohol oxidation; flow chemistry; heterogeneous catalysis; microreactors; TEMPO; Introduction Microreactors have gained attention because they can help run chemical transformations more efficiently, more selectively, and with a

• higher degree of safety [1][2][3][4][5][6][7][8][9][10][11][12]. Alcohol oxidations are well suited for microreactors due to high by-product formation, catalyst contamination and safety concerns often associated with scale-up in batch reactors [13]. Recent developments in microreactor technology and

• it enables facile removal and recycling. We recently reported the development of an effective solid support for use in packed-bed microreactors [39], AMBERZYME® Oxirane (AO, 1), a commercially available resin with pendant epoxide functionalities designed for enzyme immobilization. AO is readily