Studies on the photodegradation of red, green and blue phosphorescent OLED emitters

• Susanna Schmidbauer,
• Andreas Hohenleutner and
• Burkhard König

Beilstein J. Org. Chem. 2013, 9, 2088–2096, doi:10.3762/bjoc.9.245

• , possibly competing with the above mentioned reactive oxygen species-induced degradation route may proceed via the excited state of the emitter molecule. This might be due to instability of the excited molecule itself, via interaction of the excited molecule with its local environment or even other excited

• exclusion of oxygen, however, the degradation is suppressed significantly. Therefore, reactive oxygen species are likely responsible for the decomposition of Ir(piq)3. Experiments in deuterated benzene under atmospheric conditions support this assumption showing more than 80% decrease in the complex

• that the emitters can be very susceptible to singlet oxygen-induced degradation depending on their structure. This pathway was identified as the predominant degradation mechanism for the red emitting Ir(piq)3. Ir(Me-ppy)3 also showed sensitivity towards reactive oxygen species and an oxidized

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

• Todd J. Eckroat,
• Abdelrahman S. Mayhoub and
• Sylvie Garneau-Tsodikova

Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116

• neurons and acetylcholine (ACh) levels, plaques caused by aggregation of the protein fragment amyloid-β (Aβ), tangles associated with irregular phosphorylation of tau protein, inflammation and increased oxidative stress from reactive oxygen species (ROS), as well as dyshomeostasis and

Synthesis of meso-substituted dihydro-1,3-oxazinoporphyrins

• Satyasheel Sharma and
• Mahendra Nath

Beilstein J. Org. Chem. 2013, 9, 496–502, doi:10.3762/bjoc.9.53

• tissue, and efficiency in generating reactive oxygen species by the absorption of photons in the visible or near IR region make them ideal candidates for developing effective photodynamic agents. These findings have encouraged researchers to design and synthesize potential targeting anticancer drugs

Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates

• Wang-Yong Yang,
• Samantha A. Marrone,
• Nalisha Minors,
• Diego A. R. Zorio and
• Igor V. Alabugin

Beilstein J. Org. Chem. 2011, 7, 813–823, doi:10.3762/bjoc.7.93

• . The observed scavenger effects suggest different DNA damage mechanisms for the three lysine conjugates: Guanine oxidation and/or base alkylation for conjugate 1, guanine oxidation and generation of reactive oxygen species for conjugate 6, and guanine oxidation for conjugate 7. Cell proliferation assay

Effect of transannular interaction on the redox- potentials in a series of bicyclic quinones

• Grigoriy Sereda,
• Jesse Van Heukelom,
• Miles Koppang,
• Sudha Ramreddy and
• Nicole Collins

Beilstein J. Org. Chem. 2006, 2, No. 26, doi:10.1186/1860-5397-2-26

• to the free radical redox-processes, involving triptycene-quinones and reactive oxygen species [2]. Better understanding of the transannular influence of a substituent on the redox-potentials of bicyclo[2.2.2]octane-derived quinones will help in the design of new compounds with controlled biological