Search results

Search for "reductive cleavage" in Full Text gives 53 result(s) in Beilstein Journal of Organic Chemistry.

Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation

  • Jingjing Wu,
  • Hui Li and
  • Song Cao

Beilstein J. Org. Chem. 2011, 7, 1070–1074, doi:10.3762/bjoc.7.123

Graphical Abstract
  • continuation of our interest in the synthesis of diverse difluoromethyl-containing pseudopeptides, we herein report a novel and efficient synthesis of difluoromethyl-containing pseudopeptides through Ugi reaction, with gem-difluoromethylene-containing acid as a key component, followed by reductive cleavage of
  • building block 2 were subjected to Ugi reaction under solvent-free conditions, followed by reductive cleavage of the phenylsulfanyl group. It was found that both Ugi reaction and desulfanylation proceeded smoothly for all substrates used to give the corresponding difluoromethylene-containing and
  • building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile. Keywords: difluoromethyl functionality; gem-difluoromethylene-containing acid; pseudopeptides; reductive
PDF
Album
Supp Info
Full Research Paper
Published 08 Aug 2011

Photocycloaddition of aromatic and aliphatic aldehydes to isoxazoles: Cycloaddition reactivity and stability studies

  • Axel G. Griesbeck,
  • Marco Franke,
  • Jörg Neudörfl and
  • Hidehiro Kotaka

Beilstein J. Org. Chem. 2011, 7, 127–134, doi:10.3762/bjoc.7.18

Graphical Abstract
  • . Photochemical ring contraction of isoxazoles 7f–7h. Photocycloaddition of aromatic aldehydes to di- and trimethyl isoxazoles 7d and 7e. Preparative photocycloadditions of 7e with aromatic aldehydes. T-type photochromism of isoxazole–aldehyde pairs. Reductive cleavage of the trimethylisoxazole adduct 9a
PDF
Album
Full Research Paper
Published 26 Jan 2011

Design and synthesis of a cyclitol-derived scaffold with axial pyridyl appendages and its encapsulation of the silver(I) cation

  • Pierre-Marc Léo,
  • Christophe Morin and
  • Christian Philouze

Beilstein J. Org. Chem. 2010, 6, 1022–1024, doi:10.3762/bjoc.6.115

Graphical Abstract
  • , upon complexation with participation of three oxygen atoms in the binding, no substantial rearrangement of this semi-rigid structure is to be expected. In addition, reductive cleavage of one of the ortho-ester C–H benzylic bonds, which is known to yield a free hydroxy group [15][16], would allow
PDF
Album
Supp Info
Letter
Published 29 Oct 2010
Other Beilstein-Institut Open Science Activities