From discovery to production: Scale- out of continuous flow meso reactors

• Peter Styring and
• Ana I. R. Parracho

Beilstein J. Org. Chem. 2009, 5, No. 29, doi:10.3762/bjoc.5.29

• further study and even commercialisation it is then required to be produced on a larger scale. The problem is that to move from small discovery to larger pilot or commercial scale production is not simply a case of scaling up the quantities of reagents and solvents [4]. There are also supply issues when

• containment in the case of a failure [2][3]. Scaling up in volume of a reactor has implications on the mass and heat transfer within the system so the reaction must be re-optimised for the prevailing conditions. This is a time-consuming process and often results in the abandoning of the bench scale process in