Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles

• Guillaume G. Launay,
• Alexandra M. Z. Slawin and
• David O'Hagan

Beilstein J. Org. Chem. 2010, 6, No. 41, doi:10.3762/bjoc.6.41

• in the products, differing only in the orientation of the fluorine. In general, these reactions gave good diastereoselectivities in moderate to good yields (Scheme 3). Aza-Prins fluorination reaction The aza-Prins reaction is less well known but has been exploited, e.g., in tandem reactions in

Solvent-free phase-vanishing reactions with PTFE (Teflon^®) as a phase screen

• Kevin Pels and
• Veljko Dragojlovic

Beilstein J. Org. Chem. 2009, 5, No. 75, doi:10.3762/bjoc.5.75

• a very good yield (Table 3, entry 2). Bromination of 3-butenoic acid (21) gave the corresponding lactone 22 as the minor product while the dibromoacid 23 was the major product. We examined the possibility of tandem reactions with a solvent-free Diels-Alder/halolactonization reaction. Cyclopentadiene

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

• David M. Hodgson and
• Leonard H. Winning

Beilstein J. Org. Chem. 2008, 4, No. 38, doi:10.3762/bjoc.4.38

• -azabenzonorbornadienes. Oxidation (using RuO4) and Birch reduction of the 2-aza-5,6-benzonorbornenes provide access to substituted pyrrolidines and tetrahydroindenes, respectively. Keywords: asymmetric synthesis; deoxygenation; radicals; rearrangements; tandem reactions; Introduction Carbon-centred radicals have been

Combining two-directional synthesis and tandem reactions, part 11: second generation syntheses of (±)-hippodamine and (±)-epi-hippodamine

• Annabella F. Newton,
• Martin Rejzek,
• Marie-Lyne Alcaraz and
• Robert A. Stockman

Beilstein J. Org. Chem. 2008, 4, No. 4, doi:10.1186/1860-5397-4-4