Synthesis and enzymatic evaluation of 2- and 4-aminothiazole- based inhibitors of neuronal nitric oxide synthase

• Graham R. Lawton,
• Haitao Ji,
• Pavel Martásek,
• Linda J. Roman and
• Richard B. Silverman

Beilstein J. Org. Chem. 2009, 5, No. 28, doi:10.3762/bjoc.5.28

• useful nNOS-selective inhibitors is a difficult task as the substrate for all three isoforms is L-arginine, and so they have similar active sites. In recent years, we have developed several potent and highly selective inhibitors of nNOS that have solved this problem by exploiting subtle differences among