Diels- Alder reactions using 4,7-dioxygenated indanones as dienophiles for regioselective construction of oxygenated 2,3-dihydrobenz[f]indenone skeleton

• Natsuno Etomi,
• Takuya Kumamoto,
• Waka Nakanishi and
• Tsutomu Ishikawa

Beilstein J. Org. Chem. 2008, 4, No. 15, doi:10.3762/bjoc.4.15

• indanetrione 8, but attempts with bromoindanone 18 resulted in no reaction even under reflux. Utilization of a milder oxidant phenyliodosyl bis(trifluoroacetate) (PIFA) [33] for the oxidation of phenolic indanone 20, derived from 18 by selective demethylation with magnesium iodide (MgI2) [34], gave

Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

• Karunananda Bombuwala,
• Thomas Kinstle,
• Vladimir Popik,
• Sonal O. Uppal,
• James B. Olesen,
• Jose Viña and
• Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

• , is essential for microtubule binding activity, as change of the keto group to a thioketo group or demethylation of the OMe group in this ring reduced the activity [31](reviewed in [2]). Demethylation of the OMe group in ring A also decreased the activity, indicating the importance of this ring for