Oxidative cyclization of alkenols with Oxone using a miniflow reactor

• Yoichi M. A. Yamada,
• Kaoru Torii and
• Yasuhiro Uozumi

Beilstein J. Org. Chem. 2009, 5, No. 18, doi:10.3762/bjoc.5.18

• conclusion, we have developed a miniflow reaction system for the oxidative cyclization of alkenols with Oxone, affording the corresponding cyclic ethers in high conversion, where potentially explosive Oxone was used and quenched safely. Development of instantaneous flow reaction systems for the oxidation

• reactions with a retention time of several seconds is currently in progress. Miniflow reaction system of oxidative cyclization. The oxidative cyclization of an alkenol 1a with Oxone under batch conditions. Oxidative cyclization of alkenols with Oxone through a miniflow reactor.a Acknowledgements This work

Do α-acyloxy and α-alkoxycarbonyloxy radicals fragment to form acyl and alkoxycarbonyl radicals?

• Dennis P. Curran and
• Tiffany R. Turner

Beilstein J. Org. Chem. 2006, 2, No. 10, doi:10.1186/1860-5397-2-10

• oxidation reactions, especially those run under ostensibly reducing conditions [9]. The oxidation step may be inefficient and is almost surely a chain-breaking event. Thus, when the rate of the unspecified oxidation reaction(s) begins to exceed the rate of reduction of radicals 13a by tin hydride, the whole

Towards practical biocatalytic Baeyer- Villiger reactions: applying a thermostable enzyme in the gram- scale synthesis of optically- active lactones in a two-liquid- phase system

• Frank Schulz,
• François Leca,
• Frank Hollmann and
• Manfred T. Reetz

Beilstein J. Org. Chem. 2005, 1, No. 10, doi:10.1186/1860-5397-1-10

• Frank Schulz Francois Leca Frank Hollmann Manfred T. Reetz Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim/Ruhr, Germany 10.1186/1860-5397-1-10 Abstract Baeyer-Villiger monooxygenases (BVMOs) are extremely promising catalysts useful for enantioselective oxidation

• reactions of ketones, but organic chemists have not used them widely due to several reasons. These include instability of the enzymes in the case of in vitro and even in vivo systems, reactant/product inhibition, problems with upscaling and the necessity of using specialized equipment. The present study