The mechanochemical synthesis of quinazolin-4(3H)-ones by controlling the reactivity of IBX

• Md Toufique Alam,
• Saikat Maiti and
• Prasenjit Mal

Beilstein J. Org. Chem. 2018, 14, 2396–2403, doi:10.3762/bjoc.14.216

• aniline derivative with moderate reactivity. Therefore, we anticipate that the controlled reactivity of IBX under mechano-milling conditions led to successful reaction with 2-aminobenzamide. Finally, a large scale synthesis was performed to prove the synthetic utility of this methodology. By taking

Hypervalent iodine compounds for anti-Markovnikov-type iodo-oxyimidation of vinylarenes

• Igor B. Krylov,
• Stanislav A. Paveliev,
• Mikhail A. Syroeshkin,
• Alexander A. Korlyukov,
• Pavel V. Dorovatovskii,
• Yan V. Zubavichus,
• Gennady I. Nikishin and
• Alexander O. Terent’ev

Beilstein J. Org. Chem. 2018, 14, 2146–2155, doi:10.3762/bjoc.14.188

• %) without column chromatography (Scheme 4). The synthetic utility of the obtained products 3aa and 3ab was demonstrated by the substitution of the iodine atom with O- (methanol), S- (benzenesulfinate) and N- (azide) nucleophiles (Scheme 5). It is noteworthy that the reaction of compound 3aa with sodium

• –ka, 3ab–db, 3fb, 3hb, and 3kb. The proposed mechanism of iodo-oxyimidation of styrene (1a) using the NHPI/I2/PhI(OAc)2 system with the formation of product 3aa. Gram-scale synthesis of compound 3aa. Synthetic utility of the iodo-oxyimides 3aa and 3ab. Optimization of the synthesis of iodo

Thiocarbonyl-enabled ferrocene C–H nitrogenation by cobalt(III) catalysis: thermal and mechanochemical

• Santhivardhana Reddy Yetra,
• Zhigao Shen,
• Hui Wang and
• Lutz Ackermann

Beilstein J. Org. Chem. 2018, 14, 1546–1553, doi:10.3762/bjoc.14.131

• products, the amidated thiocarbonylferrocene 3aa could be easily transformed into the corresponding synthetically useful aminoketone 4aa (Scheme 6), illustrating the unique synthetic utility of our strategy. Mechanochemical molecular synthesis has attracted recent renewed attention as an attractive

Synthesis of chiral 3-substituted 3-amino-2-oxindoles through enantioselective catalytic nucleophilic additions to isatin imines

• Hélène Pellissier

Beilstein J. Org. Chem. 2018, 14, 1349–1369, doi:10.3762/bjoc.14.114

• enantioselectivities (90–94% ee), as shown in Scheme 5. The synthetic utility of this novel methodology was demonstrated through the total synthesis of the natural product (−)-psychotriasine (Scheme 5) and the biologically active compound AG-041R (Scheme 1). By using another type of organocatalyst, such as L

Atom-economical group-transfer reactions with hypervalent iodine compounds

• Andreas Boelke,
• Peter Finkbeiner and
• Boris J. Nachtsheim

Beilstein J. Org. Chem. 2018, 14, 1263–1280, doi:10.3762/bjoc.14.108

• ]. Here, symmetrical diaryliodonium salts 1 were used in a palladium-catalysed cross-coupling reaction with sodium tetraphenylborate (Scheme 3). This reaction not only provides excellent yields of the respective biphenyls 3 but also exhibits a high AE (57% for Ar = Ph). However, its general synthetic

• utility is limited since it requires highly reactive boron compounds as nucleophiles. Symmetrical biphenyls 3’ can be generated from the corresponding symmetrically substituted diaryliodonium salts 1 and bis(pinacolato)diboron as demonstrated by Muñiz and co-workers [25]. In the first step, a mild carbon

Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

• Dan Liu,
• Ya-Li Guo,
• Jin Qu and
• Chi Zhang

Beilstein J. Org. Chem. 2018, 14, 1112–1119, doi:10.3762/bjoc.14.97

• [43][44]. Due to the particular significance of cyclic peptides, chemists pay considerable attention to the efficient synthesis of cyclic peptides [45]. In the second part of the investigation of the synthetic utility of the FPID/(4-MeOC6H4)3P system, we tested this system in the cyclic peptide

One-pot synthesis of diaryliodonium salts from arenes and aryl iodides with Oxone–sulfuric acid

• Natalia Soldatova,
• Pavel Postnikov,
• Olga Kukurina,
• Viktor V. Zhdankin,
• Akira Yoshimura,
• Thomas Wirth and
• Mekhman S. Yusubov

Beilstein J. Org. Chem. 2018, 14, 849–855, doi:10.3762/bjoc.14.70

• lower yield. With the optimized procedure, the synthetic utility of this method using various aryliodides and arenes was investigated (Table 2). Iodobenzene (1a) smoothly reacts with arenes containing electron-donating substituents to form the corresponding iodonium salts in high yields. 3

Liquid-assisted grinding and ion pairing regulates percentage conversion and diastereoselectivity of the Wittig reaction under mechanochemical conditions

• Kendra Leahy Denlinger,
• Lianna Ortiz-Trankina,
• Preston Carr,
• Kingsley Benson,
• Daniel C. Waddell and
• James Mack

Beilstein J. Org. Chem. 2018, 14, 688–696, doi:10.3762/bjoc.14.57

• of the Wittig reaction under mechanochemical conditions [17][18]. The Wittig reaction is one of the most useful reactions for the synthesis of olefins [19][20][21][22][23]. Aside from its synthetic utility, its unique reaction mechanism (shown in Figure 1) and inherent diastereoselectivity has led to

Novel amide-functionalized chloramphenicol base bifunctional organocatalysts for enantioselective alcoholysis of meso-cyclic anhydrides

• Lingjun Xu,
• Shuwen Han,
• Linjie Yan,
• Haifeng Wang,
• Haihui Peng and
• Fener Chen

Beilstein J. Org. Chem. 2018, 14, 309–317, doi:10.3762/bjoc.14.19

• furnish the desired products. Application of this methodology to the synthesis of (S)-GABOB (13), a metabolic derivative of the neurotransmitter γ-aminobutanoic acid, was performed to illustrate the synthetic utility [58][59] (Scheme 2). From commercially available diethyl 3-hydroxyglutarate (10

Quinone-catalyzed oxidative deformylation: synthesis of imines from amino alcohols

• Xinyun Liu,
• Johnny H. Phan,
• Benjamin J. Haugeberg,
• Shrikant S. Londhe and
• Michael D. Clift

Beilstein J. Org. Chem. 2017, 13, 2895–2901, doi:10.3762/bjoc.13.282

• iminoquinone intermediate is likely required for productive reactivity. To demonstrate the synthetic utility of this methodology, we performed a sequential oxidative deformylation/Mukaiyama−Mannich addition under our previously reported conditions for decarboxylative amino acid homologation (Scheme 4) [32]. In

A Brønsted base-promoted diastereoselective dimerization of azlactones

• Danielle L. J. Pinheiro,
• Gabriel M. F. Batista,
• Pedro P. de Castro,
• Leonã S. Flores,
• Gustavo F. S. Andrade and
• Giovanni W. Amarante

Beilstein J. Org. Chem. 2017, 13, 2663–2670, doi:10.3762/bjoc.13.264

• reaction order for azlactone has also been confirmed using the technique of initial rates varying the initial concentrations of azlactone 1a (See Supporting Information File 1). Finally, the synthetic utility of the dimerization products was demonstrated by stereocontrolled reduction of the dimer 2c

Enzymatic separation of epimeric 4-C-hydroxymethylated furanosugars: Synthesis of bicyclic nucleosides

• Neha Rana,
• Manish Kumar,
• Vinod Khatri,
• Jyotirmoy Maity and
• Ashok K. Prasad

Beilstein J. Org. Chem. 2017, 13, 2078–2086, doi:10.3762/bjoc.13.205

• acetylation, has been confirmed by an X-ray study on their corresponding 4-C-p-toluenesulfonyloxymethyl derivatives. Furthermore, the two separated epimers were used for the convergent synthesis of two different types of bicyclic nucleosides, which confirms their synthetic utility. Keywords

The chemistry and biology of mycolactones

• Matthias Gehringer and
• Karl-Heinz Altmann

Beilstein J. Org. Chem. 2017, 13, 1596–1660, doi:10.3762/bjoc.13.159

Nitration of 5,11-dihydroindolo[3,2-b]carbazoles and synthetic applications of their nitro-substituted derivatives

• Roman A. Irgashev,
• Nikita A. Kazin,
• Gennady L. Rusinov and
• Valery N. Charushin

Beilstein J. Org. Chem. 2017, 13, 1396–1406, doi:10.3762/bjoc.13.136

• reductive conditions, forming 6,12-unsubstituted derivatives as major products. At the same time, 6,12-dinitro-ICZs demonstrate a remarkable synthetic utility, since both electrophilic and nucleophilic aromatic substitution procedures can successfully be used for their transformations. For instance, we have

Studies directed toward the exploitation of vicinal diols in the synthesis of (+)-nebivolol intermediates

• Runjun Devi and
• Sajal Kumar Das

Beilstein J. Org. Chem. 2017, 13, 571–578, doi:10.3762/bjoc.13.56

• heterocycles has been tremendous, its synthetic utility toward chiral benzo-annulated heterocycles is relatively limited. Thus, in the search for wider applications of Sharpless asymmetric dihydroxylation-derived diols for the synthesis of benzo-annulated heterocycles, we report herein our studies in the

Brønsted acid-mediated cyclization–dehydrosulfonylation/reduction sequences: An easy access to pyrazinoisoquinolines and pyridopyrazines

• Ramana Sreenivasa Rao and
• Chinnasamy Ramaraj Ramanathan

Beilstein J. Org. Chem. 2017, 13, 428–440, doi:10.3762/bjoc.13.46

• evidence for cyclized compounds 9b and 10a was supported by single-crystal X-ray diffraction analysis (Figure 3) in addition to IR, NMR and HRMS data. To show the synthetic utility of substituted pyrazinones, we introduce a phenyl group at the C-3 position in pyrazinone derivative 10a. To begin with, the

• -diamides furnished the substituted pyrazinones through an acid–mediated dehydrosulfonylation in methanol. This strategy can be adopted to develop value added pyrazinone-based potential precursors useful to synthesize various drug targets. Further, the synthetic utility of pyrazinoisoquinoline was

Electron-transfer-initiated benzoin- and Stetter-like reactions in packed-bed reactors for process intensification

• Anna Zaghi,
• Daniele Ragno,
• Graziano Di Carmine,
• Carmela De Risi,
• Olga Bortolini,
• Pier Paolo Giovannini,
• Giancarlo Fantin and
• Alessandro Massi

Beilstein J. Org. Chem. 2016, 12, 2719–2730, doi:10.3762/bjoc.12.268

• examples, α-hydroxy ketones (benzoin reaction) and 1,4-diketones (Stetter reaction) [1][2][3][4]. The synthetic utility of the umpolung methodology has therefore spurred intensive research on process intensification through the heterogeneization of NHC catalysts [5][6][7][8][9] for facilitating the post

A versatile route to polythiophenes with functional pendant groups using alkyne chemistry

• Xiao Huang,
• Li Yang,
• Rikard Emanuelsson,
• Jonas Bergquist,
• Maria Strømme,
• Martin Sjödin and
• Adolf Gogoll

Beilstein J. Org. Chem. 2016, 12, 2682–2688, doi:10.3762/bjoc.12.265

• . The synthetic utility of pyEDOT is demonstrated by the following examples involving a range of pendant groups. The electron acceptor units diethyl terephthalate (DET) and 9,10-anthraquinone (AQ) are of particular interest for their redox chemistry in energy storage applications [34]. Their ester and

Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation

• Olga C. Dennehy,
• Valérie M. Y. Cacheux,
• Benjamin J. Deadman,
• Denis Lynch,
• Stuart G. Collins,
• Humphrey A. Moynihan and
• Anita R. Maguire

Beilstein J. Org. Chem. 2016, 12, 2511–2522, doi:10.3762/bjoc.12.246

• -chloroacrylamides; cascade reactions; flow chemistry; Introduction Since the efficient and highly stereoselective transformation of α-thioamides to the corresponding α-thio-β-chloroacrylamides derivatives was first reported [1][2], the considerable synthetic utility of these heavily functionalized acrylamide

Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides

• Andrew W. Truman

Beilstein J. Org. Chem. 2016, 12, 1250–1268, doi:10.3762/bjoc.12.120

• macrocyclisation found in NRP biosynthesis, although the energetic demands of breaking an amide bond versus a thioester bond are notably different. PatG may have synthetic utility, as studies with unnatural substrates have shown that macrocycles of between 5–22 residues can be produced [108], despite it naturally

Synthesis of 2-oxindoles via 'transition-metal-free' intramolecular dehydrogenative coupling (IDC) of sp² C–H and sp³ C–H bonds

• Nivesh Kumar,
• Santanu Ghosh,
• Subhajit Bhunia and
• Alakesh Bisai

Beilstein J. Org. Chem. 2016, 12, 1153–1169, doi:10.3762/bjoc.12.111

• article, we disclose the scope and limitations of 'transition-metal-free' IDC of Csp2-H and Csp3-H using iodine and N-iodosuccinimide (NIS) as oxidants. In addition, we have also demonstrated the synthetic utility of oxidative coupling products in the syntheses of 3-substituted-2-oxindoles, via a

Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update

• Bin Yu,
• Hui Xing,
• De-Quan Yu and
• Hong-Min Liu

Beilstein J. Org. Chem. 2016, 12, 1000–1039, doi:10.3762/bjoc.12.98

• . Inspired by the biological potential and synthetic utility, metal- or organo-catalyzed asymmetric synthesis of chiral 3-hydroxyoxindoles have been highly pursued in the last decades. An excellent review by Chimni and co-workers summarized the catalytic strategies for the enantioselective synthesis of

(Thio)urea-mediated synthesis of functionalized six-membered rings with multiple chiral centers

• Giorgos Koutoulogenis,
• Nikolaos Kaplaneris and
• Christoforos G. Kokotos

Beilstein J. Org. Chem. 2016, 12, 462–495, doi:10.3762/bjoc.12.48

• (>95:5 dr and up to 96% ee), employing only 3 mol % catalyst loading. The synthetic utility of the process was further expanded by the multigram version of the reaction utilizing only 0.5 mol % catalyst loading and by the transformations of the adducts into other synthetic intermediates by oxidation

Cascade alkylarylation of substituted N-allylbenzamides for the construction of dihydroisoquinolin-1(2H)-ones and isoquinoline-1,3(2H,4H)-diones

• Ping Qian,
• Bingnan Du,
• Wei Jiao,
• Haibo Mei,
• Jianlin Han and
• Yi Pan

Beilstein J. Org. Chem. 2016, 12, 301–308, doi:10.3762/bjoc.12.32

• corresponding products (5ae1–5ae5) with 42% total yield. To extend the synthetic utility of this radical cyclization reaction, N-methacryloyl-N-methylbenzamide derivatives 6 were then tried as substrates for this reaction (Scheme 4). It should be mentioned that only a few radical precursors, such as the TMSCF3

Direct estimate of the internal π-donation to the carbene centre within N-heterocyclic carbenes and related molecules

• Diego M. Andrada,
• Nicole Holzmann,
• Thomas Hamadi and
• Gernot Frenking

Beilstein J. Org. Chem. 2015, 11, 2727–2736, doi:10.3762/bjoc.11.294

• has become a major field of chemical research [2][3][4]. The outstanding stability and synthetic utility of N-heterocyclic carbenes (NHCs) is an ongoing subject to an ubiquitous number of experimental and computational studies exploring their structural and electronic properties [5][6][7][8]. In the