A divergent asymmetric approach to aza-spiropyran derivative and (1S,8aR)-1-hydroxyindolizidine

• Jian-Feng Zheng,
• Wen Chen,
• Su-Yu Huang,
• Jian-Liang Ye and
• Pei-Qiang Huang

Beilstein J. Org. Chem. 2007, 3, No. 41, doi:10.1186/1860-5397-3-41

• of enantiomeric malimide-based synthetic methodologies, [35][36][37][38] we now report concise and highly diastereoselective syntheses of an aza-spiropyran derivative 7 and (1S,8aR)-1-hydroxyindolizidine (ent-3). Results and discussion Previously, we have shown that the addition of Grignard reagents

Pd-catalysed [3 + 3] annelations in the stereoselective synthesis of indolizidines

• Olivier Y. Provoost,
• Andrew J. Hazelwood and
• Joseph P. A. Harrity

Beilstein J. Org. Chem. 2007, 3, No. 8, doi:10.1186/1860-5397-3-8

• phosphites have been reported using Grignard reagents [14]. In addition, 31P NMR studies showed that the addition of 1 equivalent of nBuLi to P(OPri)3 gave a mixture of P(OPri)3 and PBun3 after 15 minutes (See Supporting Information File 1 for details). Interestingly however, we have found PBun3 to be