Methylidynetrisphosphonates: Promising C₁ building block for the design of phosphate mimetics

• Vadim D. Romanenko and
• Valery P. Kukhar

Beilstein J. Org. Chem. 2013, 9, 991–1001, doi:10.3762/bjoc.9.114

• μM) [46]. The antioxidant activity of the compound ArC(PO3Et2)3 (Ar = 2,6-t-Bu2-4-MeC6H2) was studied in a model oxidation of oleic acid and with biological objects (liver homogenates of Wistar rats) [36]. Among polyphosphonic acids with a geminal arrangement of phosphonic groups efficient

Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)

• Allison S. Limpert,
• Margrith E. Mattmann and
• Nicholas D. P. Cosford

Beilstein J. Org. Chem. 2013, 9, 717–732, doi:10.3762/bjoc.9.82

• focused on the reduction of these cellular pathologies. One mechanism to reduce oxidative stress in neurons is to upregulate signaling through the NF-E2-related factor 2/antioxidant response element (Nrf2/ARE) pathway, which is responsible for the upregulation of antioxidant and prosurvival genes

• significantly increased. Furthermore, primary rat neurons treated with 29 displayed an increased nuclear translocation of Nrf2 [64]. Oral treatment of transgenic SOD1 G93A mice with either 28 or 29 resulted in an increase in Nrf2 expression and nuclear localization. The levels of Nrf2-regulated antioxidant

• animals [66]. Additional work from this group identified the dopamine D2 receptor agonist, bromocriptine (32), as an NAIP upregulating compound that reduced oxidative stress through the upregulation of antioxidant proteins, such as activating transcription factor 3 (ATF3) and HO-1 [68]. In vivo studies

Zanthoxoaporphines A–C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae)

• Fidelis N. Samita,
• Louis P. Sandjo,
• Isaiah O. Ndiege,
• Ahmed Hassanali and
• Wilber Lwande

Beilstein J. Org. Chem. 2013, 9, 447–452, doi:10.3762/bjoc.9.47

• , oxoaporphine and aporphine analogues have shown antimalarial, antitrypanosomal [24], cytotoxic [25], antioxidant [26] and larvicidal activities [20][21]. Despite the reported bioactivities, some of the oxoaporphines and aporphines have undesirable effects, for instance liriodenine is mutagenic [27] and induces

Cyclodextrin-based nanosponges as drug carriers

• Francesco Trotta,
• Marco Zanetti and
• Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

• recent work, resveratrol, a polyphenolic phytoalexin present in different plant sources and which plays an important role in the prevention of many human diseases, particularly due to its antioxidant properties, was encapsulated in nanosponges. Incorporation markedly increased the solubility and

Bioactive selaginellins from Selaginella tamariscina (Beauv.) Spring

• Chao Yang,
• Yutian Shao,
• Kang Li and
• Wujiong Xia

Beilstein J. Org. Chem. 2012, 8, 1884–1889, doi:10.3762/bjoc.8.217

• -formyl-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]cyclohexa-2,5-dien-1-one. Compound 1, 2 and 3 exhibited appreciable cytotoxic activity against cultured HeLa cells (human cervical carcinoma cells), as well as significant antioxidant activity. Keywords: antioxidant

• , tocopherols, polyphenols and tannins) are the main class of antioxidants and are known to reduce the rate of oxidation by H-transfer (from their phenol groups) to the radicals [23]. There are multiple phenol groups on the large conjugated aromatic skeleton of selaginallins, and this potential antioxidant

• structural feature motivated the study on their antioxidant activity. Accordingly, the antioxidant capacity of selaginellin O (1), selaginellin M (2) and selaginellin (3) were estimated with the widely used ABTS radical-scavenging assay and FRAP assay. In both assays, all the selaginellins tested displayed

Synthesis and antiviral activities of spacer-linked 1-thioglucuronide analogues of glycyrrhizin

• Christian Stanetty,
• Andrea Wolkerstorfer,
• Hassan Amer,
• Andreas Hofinger,
• Ulrich Jordis,
• Dirk Claßen-Houben and
• Paul Kosma

Beilstein J. Org. Chem. 2012, 8, 705–711, doi:10.3762/bjoc.8.79

• saponin glycyrrhizin (GL) and its aglycon glycyrrhetinic acid (GA) are the main triterpene components of licorice roots and harbor various pharmacological activities, including antitumor, anti-inflammatory, antioxidant and antiviral properties [1][2]. The antiviral activities have been reported to be

Mutational analysis of a phenazine biosynthetic gene cluster in Streptomyces anulatus 9663

• Orwah Saleh,
• Katrin Flinspach,
• Lucia Westrich,
• Andreas Kulik,
• Bertolt Gust,
• Hans-Peter Fiedler and
• Lutz Heide

Beilstein J. Org. Chem. 2012, 8, 501–513, doi:10.3762/bjoc.8.57

• the first investigation of the regulatory genes of phenazine biosynthesis in Streptomyces. Keywords: phenazine; gene cluster; gene inactivation; Introduction Phenazine natural products have important biological activities comprising antibacterial, antifungal, antitumor, antimalarial, antioxidant and

Computational evidence for intramolecular hydrogen bonding and nonbonding X···O interactions in 2'-haloflavonols

• Tânia A. O. Fonseca,
• Matheus P. Freitas,
• Rodrigo A. Cormanich,
• Teodorico C. Ramalho,
• Cláudio F. Tormena and
• Roberto Rittner

Beilstein J. Org. Chem. 2012, 8, 112–117, doi:10.3762/bjoc.8.12

• (antioxidant, anti-inflammatory, antiviral, etc.) [12]. The goal of this work is to understand the intramolecular forces determining the preferred conformations of these molecules through the use of DFT theoretical calculations, quantum theory of atoms in molecules (QTAIM) [13][14][15][16][17] and natural bond

Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities

• Hany M. Mohamed,
• Ashraf H. F. Abd EL-Wahab,
• Ahmed M. EL-Agrody,
• Ahmed H. Bedair,
• Fathy A. Eid,
• Mostafa M. Khafagy and
• Kamal A. Abd-EL-Rehem

Beilstein J. Org. Chem. 2011, 7, 1688–1696, doi:10.3762/bjoc.7.199

• ]. Coumarins have also been reported to exhibit several biological activities, such as antimicrobial, anticancer, antifungal, anti-HIV and antioxidant properties [3][4][5][6], and they also served as versatile precursors for many organic transformations in the synthesis of a number of drug-like molecules [7][8

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

• Marcus Baumann,
• Ian R. Baxendale,
• Steven V. Ley and
• Nikzad Nikbin

Beilstein J. Org. Chem. 2011, 7, 442–495, doi:10.3762/bjoc.7.57

• carvedilol has an additional antioxidant mode of action. It has been proposed that the carbazole ring may be involved in scavenging oxygen radicals thereby accounting for reduced myocardial damage [41]. Since carbazoles are similar to indoles, analogous methods can be used for their synthesis. The key

First synthesis of 2-(benzofuran-2-yl)-6,7-methylene dioxyquinoline-3-carboxylic acid derivatives

• Wentao Gao,
• Jia Liu,
• Yun Jiang and
• Yang Li

Beilstein J. Org. Chem. 2011, 7, 210–217, doi:10.3762/bjoc.7.28

• heterocycles, 2-heteroarylbenzofuran ring systems are widely distributed in nature and have been reported to have antiviral, antioxidant and antifungal activities [9][10][11][12][13]. For example, cicerfuran (2, Figure 1), obtained from the roots of a wild species of chickpea, Cier bijugum, was reported to be

Hoveyda–Grubbs type metathesis catalyst immobilized on mesoporous molecular sieves MCM-41 and SBA-15

• Hynek Balcar,
• Tushar Shinde,
• Naděžda Žilková and
• Zdeněk Bastl

Beilstein J. Org. Chem. 2011, 7, 22–28, doi:10.3762/bjoc.7.4

• vinyl ether, the solid catalyst was separated by centrifugation and the polymer isolated by precipitation in methanol (containing 2,6-di-tert-butyl-p-cresol as an antioxidant). The polymer yield was determined gravimetrically. The molecular weight was determined by SEC and the values related to the

Differences between β-Ala and Gly-Gly in the design of amino acids-based hydrogels

• Andreea Pasc,
• Firmin Obounou Akong,
• Sedat Cosgun and
• Christine Gérardin

Beilstein J. Org. Chem. 2010, 6, 973–977, doi:10.3762/bjoc.6.109

• acid-based amphiphiles have been received much attention in the recent past on account of their biocompatibility and eco-friendly nature. Biologically inspired His-based surfactants are of particular interest not only for their antioxidant properties and their potential therapeutic effects, but also as

An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin

• Nian-Guang Li,
• Zhi-Hao Shi,
• Yu-Ping Tang,
• Jian-Ping Yang and
• Jin-Ao Duan

Beilstein J. Org. Chem. 2009, 5, No. 60, doi:10.3762/bjoc.5.60

• very efficient antioxidant [4] and appears to be active against many diseases related to ageing such as cancer [5], cardiovascular [6] and neurodegenerative [7] diseases. In blood, quercetin is found mainly in metabolized forms. The non-degradative metabolism of quercetin involves three main

Studies on polynuclear furoquinones. Part 1: Synthesis of tri- and tetra- cyclic furoquinones simulating BCD/ABCD ring system of furoquinone diterpenoids

• Faruk H. Shaik and
• Gandhi K. Kar

Beilstein J. Org. Chem. 2009, 5, No. 47, doi:10.3762/bjoc.5.47

• ], antioxidant and anti-inflammatory agent [12][13][14] as well as induces apoptosis in human leukemia cell lines [15][16]. It is believed that broad spectrum of activities of Dan Shen are mainly associated with the presence of tetra cyclic furoquinone diterpenoids like Tanshinone I [17][18], Tanshinone IIA and