A short stereoselective synthesis of (+)-(6R,2′S)-cryptocaryalactone via ring- closing metathesis

• Palakodety Radha Krishna,
• Krishnarao Lopinti and
• K. L. N. Reddy

Beilstein J. Org. Chem. 2009, 5, No. 14, doi:10.3762/bjoc.5.14

• 5,6-dihydropyrone ring of cryptocaryalactone. The advantage of this synthetic methodology is that one can in principle synthesize the other three diastereomers of cryptocaryalactone by altering the Sharpless epoxidation and Carreira’s conditions. Some natural products containing styryl lactones

(−)-Complanine, an inflammatory substance of marine fireworm: a synthetic study

• Kazuhiko Nakamura,
• Yu Tachikawa and
• Daisuke Uemura

Beilstein J. Org. Chem. 2009, 5, No. 12, doi:10.3762/bjoc.5.12

• absolute structure of complanine was unambiguously determined by means of synthetic methodology by a “chiral synthon” approach. Related amino alcohols possessing olefins from marine natural resources have been identified [3][4], but synthetic studies of these compounds have not been reported. Results and

Perhalogenated pyrimidine scaffolds. Reactions of 5-chloro- 2,4,6-trifluoropyrimidine with nitrogen centred nucleophiles

• Emma L. Parks,
• Graham Sandford,
• John A. Christopher and
• David D. Miller

Beilstein J. Org. Chem. 2008, 4, No. 22, doi:10.3762/bjoc.4.22

• functionalised pyrimidine derivatives are of great importance to the life-science industries and there exists a need for efficient synthetic methodology that allows the synthesis of polysubstituted pyrimidine derivatives that are regioselective in all stages to meet the demands of RAS techniques for applications

• . These limitations have, in part, provided added impetus for drug discovery programmes to develop effective synthetic methodology towards multiply substituted systems from simple readily accessible pyrimidine scaffolds [8]. Consequently, pyrimidine core scaffolds that bear multiple functionality, which

• core scaffold. However, as regioisomeric products are formed in both nucleophilic aromatic substitution stages, separation of the isomers is required after each step, making adoption of this scaffold for analogue synthesis less likely. There remains, therefore, a requirement for efficient synthetic

A divergent asymmetric approach to aza-spiropyran derivative and (1S,8aR)-1-hydroxyindolizidine

• Jian-Feng Zheng,
• Wen Chen,
• Su-Yu Huang,
• Jian-Liang Ye and
• Pei-Qiang Huang

Beilstein J. Org. Chem. 2007, 3, No. 41, doi:10.1186/1860-5397-3-41

• drugs for the treatment of cancer. In continuation of a project aimed at the development of enantiomeric malimide-based synthetic methodology, we now report a divergent, concise and highly diastereoselective approach for the asymmetric syntheses of an aza-spiropyran derivative 7 and (1S,8aR)-1

• provide, chemoselectively and quantitatively, the aza-spiropyran ring system 7. The results presented herein constitute a valuable extension of our malimides-based synthetic methodology. See Supporting Information File 1 for full experimental procedures and characterization data of the synthesized

• the reaction of functionalized Grignard reagent with protected (S)-malimide, either aza-spiropyran or (1S,8aR)-1-hydroxyindolizidine skeleton could be constructed in a concise and selective manner. The results presented herein constitute an important extension of our malimide-based synthetic

An easy synthesis of 5-functionally substituted ethyl 4-amino- 1-aryl- pyrazolo- 3-carboxylates: interesting precursors to sildenafil analogues

• Said A. S. Ghozlan,
• Khadija O. Badahdah and
• Ismail A. Abdelhamid

Beilstein J. Org. Chem. 2007, 3, No. 15, doi:10.1186/1860-5397-3-15

• report results of our work aimed at exploring this synthetic methodology and adoption of products for the synthesis of pyrazolo[4.3-d]pyrimidines. Thus, compounds 1a-c, were prepared according to literature procedures via coupling of ethyl cyanoacetate with aromatic diazonium salts [10]. It has been