Trifluoromethyl ethers – synthesis and properties of an unusual substituent

• Frédéric R. Leroux,
• Baptiste Manteau,
• Jean-Pierre Vors and
• Sergiy Pazenok

Beilstein J. Org. Chem. 2008, 4, No. 13, doi:10.3762/bjoc.4.13

• contribute to the critical "bioavailability" of therapeutically active compounds. The growing interest and utility of the trifluoromethoxy-substitutent in drugs and agrochemical products, presents challenging synthetic strategies which are increasing being tackled in industrial and academic research