Pd-catalyzed decarboxylative Heck vinylation of 2-nitrobenzoates in the presence of CuF₂

• Lukas J. Gooßen,
• Bettina Zimmermann and
• Thomas Knauber

Beilstein J. Org. Chem. 2010, 6, No. 43, doi:10.3762/bjoc.6.43

• acids is disclosed. In the presence of a catalyst system generated in situ from Pd(OAc)2 (2 mol %), CuF2 (2 equiv), and benzoquinone (0.5 equiv) in NMP, a wide range of olefins were coupled with various 2-nitrobenzoates at 130 °C with the release of carbon dioxide to afford the corresponding vinyl

Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• conditions as well as in supercritical carbon dioxide (scCO2), as means of creating a more ‘environmentally-friendly’ process [45]. Under the solventless or scCO2 flow conditions, the productivity of the catalyst was observed to be much higher. The use of supercritical fluids, in particular scCO2, as an

• was reduced using a cinchonidine-modified Pt/Al2O3 catalyst in a fixed bed reactor in both supercritical carbon dioxide and ethane [47]. Poliakoff and co-workers have investigated the continuous asymmetric hydrogenation of dimethyl itaconate in scCO2 [48][49]. By using the catalyst [Rh(COD)2(nbd