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Search for "biological properties" in Full Text gives 203 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Direct and indirect single electron transfer (SET)-photochemical approaches for the preparation of novel phthalimide and naphthalimide-based lariat-type crown ethers

  • Dae Won Cho,
  • Patrick S. Mariano and
  • Ung Chan Yoon

Beilstein J. Org. Chem. 2014, 10, 514–527, doi:10.3762/bjoc.10.47

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  • provided a solid foundation for the design of new strategies for the preparation of interesting members of the crown ether family. Substances that possess polyheteroatom-containing macrocyclic rings were carefully investigated owing to their interesting chemical and biological properties. Prime examples of
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Published 27 Feb 2014

A catalyst-free multicomponent domino sequence for the diastereoselective synthesis of (E)-3-[2-arylcarbonyl-3-(arylamino)allyl]chromen-4-ones

  • Pitchaimani Prasanna,
  • Pethaiah Gunasekaran,
  • Subbu Perumal and
  • J. Carlos Menéndez

Beilstein J. Org. Chem. 2014, 10, 459–465, doi:10.3762/bjoc.10.43

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  • ; Introduction Chromones are widely present in nature, especially in the plant kingdom, and a wide variety of useful biological properties are associated with them [1][2]. Chromone derivatives act as effective tyrosine and protein kinase C inhibitors [3] and display antifungal [4][5], antimycobacterial [6
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Published 21 Feb 2014

SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression

  • Silke Felix,
  • Louis P. Sandjo,
  • Till Opatz and
  • Gerhard Erkel

Beilstein J. Org. Chem. 2013, 9, 2866–2876, doi:10.3762/bjoc.9.323

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  • transiently transfected Colo 320 cells. In the current study, the fermentation, structure elucidation, and some biological properties of the compound are described. Results and Discussion Identification and structure elucidation SF002-96-1 was obtained by a bio-guided isolation procedure as a colourless oil
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Published 13 Dec 2013

Flow microreactor synthesis in organo-fluorine chemistry

  • Hideki Amii,
  • Aiichiro Nagaki and
  • Jun-ichi Yoshida

Beilstein J. Org. Chem. 2013, 9, 2793–2802, doi:10.3762/bjoc.9.314

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  • development of materials and biologically active agents. The introduction of fluorine atoms into organic molecules often exerts influences upon physical, chemical, and biological properties [1][2][3][4][5][6][7][8]. Although the fluorine atom is larger than the hydrogen atom, the replacement of hydrogen by
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Published 05 Dec 2013

The myxocoumarins A and B from Stigmatella aurantiaca strain MYX-030

  • Tobias A. M. Gulder,
  • Snežana Neff,
  • Traugott Schüz,
  • Tammo Winkler,
  • René Gees and
  • Bettina Böhlendorf

Beilstein J. Org. Chem. 2013, 9, 2579–2585, doi:10.3762/bjoc.9.293

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  • interesting biological properties are the myxobacteria [9][10][11][12]. These organisms are especially talented in assembling PKS-, NRPS- and PKS/NRPS-hybrid products, often incorporating unusual biochemistry in the respective biosynthetic pathways [13][14][15]. The most well-known myxobacterial natural
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Published 20 Nov 2013

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

  • Grégory Landelle,
  • Armen Panossian,
  • Sergiy Pazenok,
  • Jean-Pierre Vors and
  • Frédéric R. Leroux

Beilstein J. Org. Chem. 2013, 9, 2476–2536, doi:10.3762/bjoc.9.287

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  • -fluorine; transition metal; trifluoromethylation; trifluoromethylthiolation; Review Introduction The incorporation of fluorine or fluorinated moieties into organic compounds plays a key role in Life-Science oriented research as often-profound changes of the physico-chemical and biological properties can
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Published 15 Nov 2013

Synthesis of the spiroketal core of integramycin

  • Evgeny. V. Prusov

Beilstein J. Org. Chem. 2013, 9, 2446–2450, doi:10.3762/bjoc.9.282

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  • octalin fragment [4] of integramycin were recently reported by Roush and Floreancig, however, a total synthesis of this rather complex natural product has yet to be accomplished. Intrigued by its biological properties and capitalizing on our previous experience [5] in the total synthesis of natural
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Published 12 Nov 2013

Synthesis of enantiopure sugar-decorated six-armed triptycene derivatives

  • Paola Bonaccorsi,
  • Maria Luisa Di Gioia,
  • Antonella Leggio,
  • Lucio Minuti,
  • Teresa Papalia,
  • Carlo Siciliano,
  • Andrea Temperini and
  • Anna Barattucci

Beilstein J. Org. Chem. 2013, 9, 2410–2416, doi:10.3762/bjoc.9.278

Graphical Abstract
  • their biological properties [13][14]. Accordingly, we developed a methodology for obtaining molecules showing a rigid lipophilic core represented by the triptycene skeleton that is linked, by the arene rings, to six sugar moieties through six triazole units as spacers. To the best of our knowledge, this
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Published 08 Nov 2013

Synthesis of homo- and heteromultivalent carbohydrate-functionalized oligo(amidoamines) using novel glyco-building blocks

  • Felix Wojcik,
  • Sinaida Lel,
  • Alexander G. O’Brien,
  • Peter H. Seeberger and
  • Laura Hartmann

Beilstein J. Org. Chem. 2013, 9, 2395–2403, doi:10.3762/bjoc.9.276

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  • is well understood that the number and spacing of ligands have a tremendous influence on the resulting binding and thus biological properties [5][6][7]. Therefore, in order to understand and explore these interactions and their potential for biomedical applications, a more detailed look at the
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Published 07 Nov 2013

Elucidation of the regio- and chemoselectivity of enzymatic allylic oxidations with Pleurotus sapidus – conversion of selected spirocyclic terpenoids and computational analysis

  • Verena Weidmann,
  • Mathias Schaffrath,
  • Holger Zorn,
  • Julia Rehbein and
  • Wolfgang Maison

Beilstein J. Org. Chem. 2013, 9, 2233–2241, doi:10.3762/bjoc.9.262

Graphical Abstract
  • have other interesting biological properties such as phytotoxic activity. A few selected examples are depicted in Figure 2. In this paper, we report biocatalytic allylic oxidations of spirocyclic model compounds and of the natural product vitispirane with the lyophilisate of PSA. A rationalization of
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Published 29 Oct 2013

Structure of 1,5-benzodiazepinones in the solid state and in solution: Effect of the fluorination in the six-membered ring

  • Marta Pérez-Torralba,
  • Rosa M. Claramunt,
  • M. Ángeles García,
  • Concepción López,
  • M. Carmen Torralba,
  • M. Rosario Torres,
  • Ibon Alkorta and
  • José Elguero

Beilstein J. Org. Chem. 2013, 9, 2156–2167, doi:10.3762/bjoc.9.253

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  • applications in medicinal chemistry [2][3][4][5][6], the most important is clobazam (7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione, Figure 1). As a continuation of our research program on the synthesis, spectroscopic and biological properties of 1,5-benzodiazepine derivatives as well as
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Published 21 Oct 2013

The chemistry of isoindole natural products

  • Klaus Speck and
  • Thomas Magauer

Beilstein J. Org. Chem. 2013, 9, 2048–2078, doi:10.3762/bjoc.9.243

Graphical Abstract
  • representative members are depicted in Figure 5 [43]. Cyctochalasan alkaloids display a wide range of biological properties, such as cytotoxic, antimicrobial, antiviral and phytotoxic activities and were reviewed in detail by Hertweck in 2010 [44]. Structurally, they consist of one amino acid and a highly
  • interesting biological properties, such as high antiviral activity (156) [141], inhibition of the HIV-1 protease (157) [132], antibacterial and antifungal activities (159–160) [133] or neuritogenic properties (161) [134]. So far, only a few total syntheses were accomplished and the exact biosynthetic pathways
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Published 10 Oct 2013

A concise enantioselective synthesis of the guaiane sesquiterpene (−)-oxyphyllol

  • Martin Zahel and
  • Peter Metz

Beilstein J. Org. Chem. 2013, 9, 2028–2032, doi:10.3762/bjoc.9.239

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  • ; Introduction The hydroazulene framework is present in many natural products that are often associated with interesting biological properties [1][2]. The guaiane sesquiterpene (−)-oxyphyllol (1) has been isolated from the roots of the Thai medicinal plant Phyllanthus oxyphyllus [3]. A recent enantioselective
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Published 08 Oct 2013

Structure elucidation of β-cyclodextrin–xylazine complex by a combination of quantitative 1H–1H ROESY and molecular dynamics studies

  • Syed Mashhood Ali,
  • Kehkeshan Fatma and
  • Snehal Dhokale

Beilstein J. Org. Chem. 2013, 9, 1917–1924, doi:10.3762/bjoc.9.226

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  • the cavity is hydrophobic [2][3]. The encapsulation of a guest into the CD cavity has a profound effect on the chemical, physical and biological properties of the guest. The structure establishment of CD inclusion complexes in solution state is a challenging task considering the fact that the
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Published 23 Sep 2013

Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

  • Trevor A. Hamlin and
  • Nicholas E. Leadbeater

Beilstein J. Org. Chem. 2013, 9, 1843–1852, doi:10.3762/bjoc.9.215

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  • effect on the outcome of the reaction (Table 2, entries 3 and 4). The Claisen–Schmidt condensation We moved next to study the Claisen–Schmidt condensation of benzaldehyde with acetophenone to yield chalcone (Scheme 3). Chalcones display interesting biological properties such as antioxidant, cytotoxic
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Published 11 Sep 2013

Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues

  • Xu-Wen Li,
  • Jennifer Herrmann,
  • Yi Zang,
  • Philippe Grellier,
  • Soizic Prado,
  • Rolf Müller and
  • Bastien Nay

Beilstein J. Org. Chem. 2013, 9, 1551–1558, doi:10.3762/bjoc.9.176

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  • powerful inhibitors of the quinol oxidation sites of bacterial cytochromes bo and bd, with dissociation constants in the range of 10 nM. Aurachin D (4) was shown to selectively inhibit the cytochrome bd complex [12]. With such biological properties, aurachins and their analogues are also strong
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Published 31 Jul 2013

Catalytic asymmetric tandem Friedel–Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromans

  • Jiahuan Peng and
  • Da-Ming Du

Beilstein J. Org. Chem. 2013, 9, 1210–1216, doi:10.3762/bjoc.9.137

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  • synthetic molecules, and they also possess potentially useful biological properties [17][18][19][20]. The benzopyran framework has attracted considerable attention because of the importance of chromans and their biological properties. Numerous synthetic routes have been reported over the past few decades
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Published 24 Jun 2013

Selective copper(II) acetate and potassium iodide catalyzed oxidation of aminals to dihydroquinazoline and quinazolinone alkaloids

  • Matthew T. Richers,
  • Chenfei Zhao and
  • Daniel Seidel

Beilstein J. Org. Chem. 2013, 9, 1194–1201, doi:10.3762/bjoc.9.135

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  • products have been isolated from, such as Adhatoda vasica, Peganum harmala and Evodia rutaecarpa, have been used in folk medicine for centuries [6][7][8][9]. Since the original isolation of vasicine (1, Figure 1) in 1888 [10], the biological properties of this class of alkaloids have been extensively
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Published 20 Jun 2013

Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

  • Lena Möller,
  • Christian Hess,
  • Jiří Paleček,
  • Yi Su,
  • Axel Haverich,
  • Andreas Kirschning and
  • Gerald Dräger

Beilstein J. Org. Chem. 2013, 9, 270–277, doi:10.3762/bjoc.9.33

Graphical Abstract
  • that did not reveal absorption maxima between 440–600 nm. These results demonstrate that the 1,3-dipolar cycloaddition protocols gave covalently linked fluorescein–TPX membrane adducts. Endothelialization of TPX foils Based on these promising results, we next tested the biological properties of the new
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Published 08 Feb 2013

Synthesis of spiro[dihydropyridine-oxindoles] via three-component reaction of arylamine, isatin and cyclopentane-1,3-dione

  • Yan Sun,
  • Jing Sun and
  • Chao-Guo Yan

Beilstein J. Org. Chem. 2013, 9, 8–14, doi:10.3762/bjoc.9.2

Graphical Abstract
  • scope of this novel reaction is briefly discussed. Keywords: arylamine; cyclopentanedione; isatin; multicomponent reaction; spiro compound; Introduction The spirooxindole is among the most important class of naturally occurring substances, characterized by highly pronounced biological properties, and
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Published 03 Jan 2013

Multivalent display of the antimicrobial peptides BP100 and BP143

  • Imma Güell,
  • Rafael Ferre,
  • Kasper K. Sørensen,
  • Esther Badosa,
  • Iteng Ng-Choi,
  • Emilio Montesinos,
  • Eduard Bardají,
  • Lidia Feliu,
  • Knud J. Jensen and
  • Marta Planas

Beilstein J. Org. Chem. 2012, 8, 2106–2117, doi:10.3762/bjoc.8.237

Graphical Abstract
  • -melittin antimicrobial undecapeptide hybrids on a carbohydrate template could provide carbopeptides with improved biological properties. In particular, KKLFKKILKYL-NH2 (BP100) and KKLfKKILKYL-NH2 (BP143) were selected based on their high antibacterial activity against the plant pathogenic bacteria Erwinia
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Published 03 Dec 2012

Tricyclic flavonoids with 1,3-dithiolium substructure

  • Lucian G. Bahrin,
  • Peter G. Jones and
  • Henning Hopf

Beilstein J. Org. Chem. 2012, 8, 1999–2003, doi:10.3762/bjoc.8.226

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  • be obtained [31]. The above combination of the chemistry of 1,3-dithiol-2-yl cations and the biological properties of flavonoids may provide new compounds with interesting properties. Conclusion The synthesis of 3-dithiocarbamic flavonoids has been accomplished by the reaction of the corresponding 2
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Published 16 Nov 2012

An efficient access to the synthesis of novel 12-phenylbenzo[6,7]oxepino[3,4-b]quinolin-13(6H)-one derivatives

  • Wentao Gao,
  • Guihai Lin,
  • Yang Li,
  • Xiyue Tao,
  • Rui Liu and
  • Lianjie Sun

Beilstein J. Org. Chem. 2012, 8, 1849–1857, doi:10.3762/bjoc.8.213

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  • tetracyclic quinoline systems on privileged templates have significant biological properties, such as antitumoral [5][6], anti-inflammatory [7], antimalarial [8], antituberculosis [9], and antiplasmodial [10] activities. Accordingly, the synthesis of new families of such quinoline systems still attracts much
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Published 30 Oct 2012

Recyclable fluorous cinchona alkaloid ester as a chiral promoter for asymmetric fluorination of β-ketoesters

  • Wen-Bin Yi,
  • Xin Huang,
  • Zijuan Zhang,
  • Dian-Rong Zhu,
  • Chun Cai and
  • Wei Zhang

Beilstein J. Org. Chem. 2012, 8, 1233–1240, doi:10.3762/bjoc.8.138

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  • . Introducing one or a few fluorine atoms to biologically interesting molecules can significantly change the physical, chemical and biological properties [1][2]. The significant amount of publications on fluorinated small molecules, amino acids, carbohydrates, steroids and nucleosides indicates that
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Published 03 Aug 2012

Synthesis of diverse indole libraries on polystyrene resin – Scope and limitations of an organometallic reaction on solid supports

  • Kerstin Knepper,
  • Sylvia Vanderheiden and
  • Stefan Bräse

Beilstein J. Org. Chem. 2012, 8, 1191–1199, doi:10.3762/bjoc.8.132

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  • ], palladium-catalyzed indole synthesis [34][35][36][37][38][39][40], cycloaddition strategies [41], C-arylation of substituted acetonitriles or 1,3-dicarbonyl compounds [42], halocyclization [43][44] and finally, reduction of ortho-fluoro-nitroarenes [42]. The significant biological properties and the
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Published 26 Jul 2012
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