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Search for "nitrile" in Full Text gives 262 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Phosphonic acid: preparation and applications

  • Charlotte M. Sevrain,
  • Mathieu Berchel,
  • Hélène Couthon and
  • Paul-Alain Jaffrès

Beilstein J. Org. Chem. 2017, 13, 2186–2213, doi:10.3762/bjoc.13.219

Graphical Abstract
  • polymers side chains [226]. 6.2. Reactivity of phosphorous acid (H3PO3) with imine, nitrile and carbonyl groups The phosphorous acid function reacts with imine in the absence of solvent to produce α-amino-phosphonic acid as exemplified by the synthesis of the α-amino-phosphonic acid 118 from the imine 117
  • (Figure 32) [227]. It is worth noting that the reaction of H3PO3 with some enamine (e.g., 1-morpholinocyclohexene) gives a reduction of the enamine to amine. This is likely why this reaction was seldomly used. The reaction of phosphorous acid on nitrile in presence of methanesulfonic acid followed by the
  • nitrile group can be replaced in this reaction with a carboxylic acid function. In that case the final product is a hydroxymethylenebis-phosphonic acid (Figure 34). This reaction was optimized to produce, for instance, compounds 124 [233][234] or 125 [229]. This reaction is not further detailed herein as
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Published 20 Oct 2017

Mechanochemical synthesis of small organic molecules

  • Tapas Kumar Achar,
  • Anima Bose and
  • Prasenjit Mal

Beilstein J. Org. Chem. 2017, 13, 1907–1931, doi:10.3762/bjoc.13.186

Graphical Abstract
  • nearly 90% yields for α-amino esters in 90–120 min (Scheme 18). The Ritter reaction is another significant carbon–nitrogen (C–N) bond forming reaction in the synthesis of amides [86]. Generally, a nitrile and a tertiary alcohol in presence of a strong acid react to create amides. Major drawbacks
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Published 11 Sep 2017

Photocatalyzed synthesis of isochromanones and isobenzofuranones under batch and flow conditions

  • Manuel Anselmo,
  • Lisa Moni,
  • Hossny Ismail,
  • Davide Comoretto,
  • Renata Riva and
  • Andrea Basso

Beilstein J. Org. Chem. 2017, 13, 1456–1462, doi:10.3762/bjoc.13.143

Graphical Abstract
  • approaches thus arousing our interest [2]. In 2014 König reported a photo-Meerwein reaction between arenediazonium salts and styrenes to afford, upon intervention of the nitrile solvent and water, amides of formula 1 (Scheme 1) [3]. According to the proposed mechanism, the carbocationic intermediate A
  • , deriving from the corresponding radical, undergoes a nucleophilic attack by the nitrile, generating nitrilium ion B first, and subsequently evolves to the amide 1, according to a Ritter-type reaction. Based on our experience on multicomponent reactions, we postulated that intermediate A could be
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Published 25 Jul 2017

Regioselective (thio)carbamoylation of 2,7-di-tert-butylpyrene at the 1-position with iso(thio)cyanates

  • Anna Wrona-Piotrowicz,
  • Marzena Witalewska,
  • Janusz Zakrzewski and
  • Anna Makal

Beilstein J. Org. Chem. 2017, 13, 1032–1038, doi:10.3762/bjoc.13.102

Graphical Abstract
  • min, 1,8-bis-carbothioamide 4, containing ≈20% of other regioisomers (9%) and nitrile 5 (7%) were isolated by column chromatography besides the expected 3o (78%). The amounts of 4 and 5 significantly increased along with the reaction time (Table 1). The highest yield of 4 (33%) was found after 6 h
  • and contained broadened signals, suggesting the presence of other rotamers in CDCl3 solution. The mechanism of the formation of nitrile 5 in the reaction under study here is so far unclear. The control experiment showed that under reaction conditions the secondary thioamide 3o undergoes transformation
  • CH2Cl2. The combined extracts were dried over anhydrous Na2SO4 and evaporated. For the reaction with ethoxycarbonyl isothiocyanate, chromatography afforded two fractions. The less polar fraction contained monothioamide 3o and nitrile 5, whereas the more polar fraction contained dithioamides 4. The
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Published 29 May 2017

Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif

  • Tetiana Bykova,
  • Nawaf Al-Maharik,
  • Alexandra M. Z. Slawin and
  • David O'Hagan

Beilstein J. Org. Chem. 2017, 13, 728–733, doi:10.3762/bjoc.13.72

Graphical Abstract
  • moieties were then converted to different stereoisomers of the tetrafluorocyclohexyl ring system, and then reductive hydrogenation of the nitrile delivered three amine stereoisomers. It proved necessary to place a methyl group on the cyclohexane ring in order to stabilise the compound against subsequent HF
  • diastereoisomers of 8, two of which have the meso diepoxides syn and anti in relation to the nitrile functional group (8a and 8b) and a racemic 8c diepoxide with trans configuration. These isomers were generated in a ratio of 10:15:13 (8a:8b:8c) (Scheme 1) [15]. Diepoxide 8a was isolated by chromatography (18
  • formamide 12 in 78% yield, a compound also confirmed by X-ray crystallography [20]. Ultimately treatment of nitrile 11a with nickel boride generated in situ from nickel chloride and sodium borohydride, resulted in its full reduction to amine 5a in 50% yield (Scheme 2) [21][22]. The analogous protocol was
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Published 19 Apr 2017

Isoxazole derivatives as new nitric oxide elicitors in plants

  • Anca Oancea,
  • Emilian Georgescu,
  • Florentina Georgescu,
  • Alina Nicolescu,
  • Elena Iulia Oprita,
  • Catalina Tudora,
  • Lucian Vladulescu,
  • Marius-Constantin Vladulescu,
  • Florin Oancea and
  • Calin Deleanu

Beilstein J. Org. Chem. 2017, 13, 659–664, doi:10.3762/bjoc.13.65

Graphical Abstract
  • were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides, generated in situ from the corresponding hydroxyimidoyl chlorides, with non-symmetrical activated alkynes in the presence of catalytic amounts of copper(I) iodide. Effects of 3,5
  • -disubstituted isoxazoles on nitric oxide and reactive oxygen species generation in Arabidopsis tissues was studied using specific diaminofluoresceine dyes as fluorescence indicators. Keywords: chemical elicitor; 1,3-dipolar cycloaddition; isoxazole; nitric oxide; nitrile oxide; reactive oxygen species
  • synthetic approaches towards the isoxazole core include the reactions of hydroxylamine with aryl-β-diketones [20], α,β-unsaturated carbonyl compounds [21], or α,β-unsaturated nitriles [22], and 1,3-dipolar cycloaddition reactions between alkenes or alkynes and nitrile oxides [23][24][25]. Nitrile oxides are
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Published 06 Apr 2017

Synthesis of 1-indanones with a broad range of biological activity

  • Marika Turek,
  • Dorota Szczęsna,
  • Marek Koprowski and
  • Piotr Bałczewski

Beilstein J. Org. Chem. 2017, 13, 451–494, doi:10.3762/bjoc.13.48

Graphical Abstract
  • , has been reported in 2005 [6]. The studied Meldrum's acid derivatives 65 were functionalized at α- and/or β-positions by alkyl, haloalkyl, alkenyl, alkynyl, nitrile, ether, thioether, triisopropylsilyl (TIPS) or tert-butyldiphenylsilyl (TBDPS) groups. Depending on the type of catalyst and substrate, 1
  • methyl trifluoromethanesulfonate, in dichloromethane or 1,2-dichloroethane in high yields (Scheme 54). 1.5 From nitriles Nitrile derivatives are also useful substrates for the synthesis of 1-indanones. An efficient synthesis of 1-indanones 194 via palladium-catalyzed cyclization of 3-(2-iodoaryl
  • -iodoaryl)propanonitriles 193 leading to the formation of the nitrile 195 as a byproduct (Scheme 55). Cyclization of 3-phenylnaphtalene-2-carbonitrile (199) in the presence of polyphosphoric acid gave 1-indanone 200 in 76% yield. The nitrile 199 was obtained from benzaldehyde 196 as a result of sequencial
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Published 09 Mar 2017

Dimerization reactions of aryl selenophen-2-yl-substituted thiocarbonyl S-methanides as diradical processes: a computational study

  • Michael L. McKee,
  • Grzegorz Mlostoń,
  • Katarzyna Urbaniak and
  • Heinz Heimgartner

Beilstein J. Org. Chem. 2017, 13, 410–416, doi:10.3762/bjoc.13.44

Graphical Abstract
  • mechanisms in [3 + 2]-cycloadditions have intensively been studied [16] and recently, a computational study on their appearance in reactions of substituted acetylenes with nitrile oxides has been published [17]. Experimental The Gaussian 09 program system was used for all calculations [18]. The M06-2X
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Published 03 Mar 2017

Decarboxylative and dehydrative coupling of dienoic acids and pentadienyl alcohols to form 1,3,6,8-tetraenes

  • Ghina’a I. Abu Deiab,
  • Mohammed H. Al-Huniti,
  • I. F. Dempsey Hyatt,
  • Emma E. Nagy,
  • Kristen E. Gettys,
  • Sommayah S. Sayed,
  • Christine M. Joliat,
  • Paige E. Daniel,
  • Rupa M. Vummalaneni,
  • Andrew T. Morehead Jr,
  • Andrew L. Sargent and
  • Mitchell P. Croatt

Beilstein J. Org. Chem. 2017, 13, 384–392, doi:10.3762/bjoc.13.41

Graphical Abstract
  • and coupling this to a substrate with a benzylic or allylic leaving group [19][20]. Typical Pd(0)-catalyzed decarboxylative coupling reactions utilize an allylic or benzylic ester with either an anion-stabilizing group adjacent to the carboxyl group (i.e., carbonyl [19][21][22], nitrile [23][24][25
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Published 28 Feb 2017

The reductive decyanation reaction: an overview and recent developments

  • Jean-Marc R. Mattalia

Beilstein J. Org. Chem. 2017, 13, 267–284, doi:10.3762/bjoc.13.30

Graphical Abstract
  • advantages of the nitrile functional group before its removal. Mechanistic details and applications to organic synthesis are provided. Keywords: α-aminonitrile; decyanation; electron donor; hydride; malononitrile; transition metal catalysis; Introduction Many strategies in organic synthesis involve the
  • removal of a beneficial functional group. The electron-withdrawing properties of the nitrile functional group appear beneficial in a variety of reactions [1][2]. This group coordinates metal complexes and can be used as a directing group for C–H bond activation reactions catalyzed by transition metals [3
  • ] or LiAlH4 [65][66]. These reactions usually require mild conditions but the course of the reaction depends on the ease of formation of the iminium ion [48][67][68][69]. With the highly reactive LiAlH4, diamines can also be formed by reduction of the nitrile moiety [70]. This competition with the
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Published 13 Feb 2017

Highly bulky and stable geometry-constrained iminopyridines: Synthesis, structure and application in Pd-catalyzed Suzuki coupling of aryl chlorides

  • Yi Lai,
  • Zhijian Zong,
  • Yujie Tang,
  • Weimin Mo,
  • Nan Sun,
  • Baoxiang Hu,
  • Zhenlu Shen,
  • Liqun Jin,
  • Wen-hua Sun and
  • Xinquan Hu

Beilstein J. Org. Chem. 2017, 13, 213–221, doi:10.3762/bjoc.13.24

Graphical Abstract
  • (Table 4, entry 2), carbonyl (Table 4, entries 4–6), nitrile and CF3 (Table 4, entries 6 and 7) could be coupled with 4-methylphenylboric acid in good to excellent yields. Aryl chlorides with an electron-donating functional group (Table 4, entries 9 and 10) and steric hindered 2-chlorotoluene (Table 4
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Published 03 Feb 2017

Total synthesis of a Streptococcus pneumoniae serotype 12F CPS repeating unit hexasaccharide

  • Peter H. Seeberger,
  • Claney L. Pereira and
  • Subramanian Govindan

Beilstein J. Org. Chem. 2017, 13, 164–173, doi:10.3762/bjoc.13.19

Graphical Abstract
  • poor. Apparently, the “nitrile effect” [37][38] is partially overruled by the participating nature of the C3 ester protecting groups Ac/Bz that leads to a preference for the cis-glycosidic α-linked product. Linear total synthesis of 12F repeating unit hexasaccharide 1. The failure of the convergent [3
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Published 25 Jan 2017

Formose reaction accelerated in aerosol-OT reverse micelles

  • Makoto Masaoka,
  • Tomohiro Michitaka and
  • Akihito Hashidzume

Beilstein J. Org. Chem. 2016, 12, 2663–2667, doi:10.3762/bjoc.12.262

Graphical Abstract
  • removal of a large fraction of AOT (see Supporting Information File 1). Figure 4 compares 13C NMR spectra for the products of the formose reaction carried out using formaldehyde-13C at 30, 45, and 60 °C. In these spectra, signals at 1.5 and 119.5 ppm are due to the methyl and nitrile carbons in
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Published 07 Dec 2016

New syntheses of (±)-tashiromine and (±)-epitashiromine via enaminone intermediates

  • Darren L. Riley,
  • Joseph P. Michael and
  • Charles B. de Koning

Beilstein J. Org. Chem. 2016, 12, 2609–2613, doi:10.3762/bjoc.12.256

Graphical Abstract
  • approach most commonly comprise a nitrogen atom in a pyrrolidine or piperidine ring conjugated at C-2 through an exocyclic vinyl fragment to an ester (vinylogous urethane) or another electron-withdrawing substituent (usually ketone, nitrile, nitro or sulfone). When suitable carbon chains bearing terminal
  • vinylogous cyanamide 9c was not reproducible. In the best case we isolated the nitrile 12c in 85% yield. Despite repeating the reaction several times and altering reaction times and hydrogen pressure in an attempt to optimise the reaction conditions, in most cases the nitrile group also appeared to be fully
  • nitrile experiencing reproducibility issues during the cyclisation step. Key to the success of the synthesis however is the ability to remove efficiently the triphenylphosphine residues after the cyclisation step as the catalytic hydrogenation appeared to be adversely effected by the presence of these
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Published 02 Dec 2016
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  • ]. Scheme 11 shows the following literature examples of [3 + 2 + 1] cycloadditions following novel mappings (blue structures shown in Figure 9): Dabiri [189][190], and Singh [191]. The Yi [192] example follows the traditional coupling using a nitrile instead of a urea precursor, which ultimately leads to a
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Published 16 Nov 2016

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides

  • Ilya V. Efimov,
  • Marsel Z. Shafikov,
  • Nikolai A. Beliaev,
  • Natalia N. Volkova,
  • Tetyana V. Beryozkina,
  • Wim Dehaen,
  • Zhijin Fan,
  • Viktoria V. Grishko,
  • Gert Lubec,
  • Pavel A. Slepukhin and
  • Vasiliy A. Bakulev

Beilstein J. Org. Chem. 2016, 12, 2390–2401, doi:10.3762/bjoc.12.233

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  • Lazarettgasse, 1090 Vienna, Austria I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, 20 S. Kovalevskaya str., 620990 Yekaterinburg, Russia 10.3762/bjoc.12.233 Abstract Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical
  • -5-substituted isoxazoles that are otherwise difficult to obtain. Keywords: β-azolyl enamine; [3 + 2]-cycloaddition; isoxazole; isoxazoline; nitrile oxide; Introduction The biological activity and technically useful properties of isoxazoles have made them the focus of both medicinal and materials
  • -azolyl-1,3-dicarbonyl compounds with hydroxylamine and cyanomethylazoles with hydroxamoyl chlorides are used for the synthesis of a few representatives of 4-(azol-5-yl)isoxazoles [1][4][12][13][14][15][16]. Cycloaddition reactions of azolylacetylenes with nitrile oxides are an alternative method for the
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Published 15 Nov 2016

Robust C–C bonded porous networks with chemically designed functionalities for improved CO2 capture from flue gas

  • Damien Thirion,
  • Joo S. Lee,
  • Ercan Özdemir and
  • Cafer T. Yavuz

Beilstein J. Org. Chem. 2016, 12, 2274–2279, doi:10.3762/bjoc.12.220

Graphical Abstract
  • through metal-free Knoevenagel nitrile–aldol condensation, namely the covalent organic polymer, COP-156 and 157. COP-156, due to high specific surface area (650 m2/g) and easily interchangeable nitrile groups, was modified post-synthetically into free amine- or amidoxime-containing networks. The modified
  • formation of these structures do not allow obtaining free nitrile or amine functionalities. The most used strategy to install available functional groups on porous materials is through post-modification, which often requires several steps and harsh conditions, and yields low porosity [12][13]. The
  • Knoevenagel condensation of benzyl nitriles and aldehydes produces C–C bonded products with labile nitrile functionalities. In fact, nitrile groups have been shown in porous polymers (particularly in polymers of intrinsic microporosity (PIMs)) to be good precursors to several functionalities like carboxylic
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Published 28 Oct 2016

Elongated and substituted triazine-based tricarboxylic acid linkers for MOFs

  • Arne Klinkebiel,
  • Ole Beyer,
  • Barbara Malawko and
  • Ulrich Lüning

Beilstein J. Org. Chem. 2016, 12, 2267–2273, doi:10.3762/bjoc.12.219

Graphical Abstract
  • substituted) with two equivalents of an unsubstituted nitrile. Triple Suzuki coupling of the cores 3 with suitable phenyl- and biphenylboronic acid derivatives provided elongated tricarboxylic acid linkers as carboxylic acids 17 and 20 or their esters 16 and 19. Reduction of the nitro group and cleavage of
  • trimerization of respective nitriles [13]. Unsymmetric 1,3,5-triazines 3 can be made by combining one equivalent of an acid chloride with two equivalents of a nitrile [14][15][16] (for a recently described alternative access to unsymmetrical 1,3,5-triazines; see [17]). In the presence of a suitable Lewis acid
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Published 27 Oct 2016

Regiocontroled Pd-catalysed C5-arylation of 3-substituted thiophene derivatives using a bromo-substituent as blocking group

  • Mariem Brahim,
  • Hamed Ben Ammar,
  • Jean-François Soulé and
  • Henri Doucet

Beilstein J. Org. Chem. 2016, 12, 2197–2203, doi:10.3762/bjoc.12.210

Graphical Abstract
  • yield of 85% of 10 was obtained with 4-bromo-2-(trifluoromethyl)nitrobenzene. Then, the reactivity of a set of ortho-substituted aryl bromides was examined. Bromobenzene containing nitro, nitrile or formyl ortho-substituents afforded the C5-arylated thiophenes 11–13 in 71–84% yields. Finally, 3
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Published 17 Oct 2016

Stereo- and regioselectivity of the hetero-Diels–Alder reaction of nitroso derivatives with conjugated dienes

  • Lucie Brulíková,
  • Aidan Harrison,
  • Marvin J. Miller and
  • Jan Hlaváč

Beilstein J. Org. Chem. 2016, 12, 1949–1980, doi:10.3762/bjoc.12.184

Graphical Abstract
  • treatment of a nitronate anion with oxalyl chloride were recently published [61][62] (Scheme 6). Acylnitroso compounds are generally prepared and used in situ due to their extremely reactive nature and the conditions have been summarized previously [16]. These include the oxidation of nitrile oxides [63] or
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Published 01 Sep 2016

One-pot synthesis of 4′-alkyl-4-cyanobiaryls on the basis of the terephthalonitrile dianion and neutral aromatic nitrile cross-coupling

  • Roman Yu. Peshkov,
  • Elena V. Panteleeva,
  • Wang Chunyan,
  • Evgeny V. Tretyakov and
  • Vitalij D. Shteingarts

Beilstein J. Org. Chem. 2016, 12, 1577–1584, doi:10.3762/bjoc.12.153

Graphical Abstract
  • method is based on biaryl cross-coupling between the sodium salt of the terephthalonitrile dianion and a neutral aromatic nitrile in liquid ammonia, and successive alkylation of the long-lived anionic intermediate with alkyl bromides. The reaction is compatible with benzonitriles that contain methyl
  • Discussion The suggested one-pot synthesis of alkylcyanobiaryls 5 comprises consecutive generation of terephthalonitrile dianion (12–) [30][31][32] by the addition of metallic sodium to a suspension of dinitrile 1 in liquid ammonia, treating of the thus formed 12− salt with a twofold excess of nitrile 2
  • of the cyanophenyl fragment of dianion 12− into the para-position of nitrile 2a with the formation of cyclohexadienyl anion 3 after rapid decyanation of the primary cross-coupling dianionic product. Next, the alkylation of intermediate 3 occurs at the position ipso to the cyano group. This
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Published 25 Jul 2016

Molecular weight control in organochromium olefin polymerization catalysis by hemilabile ligand–metal interactions

  • Stefan Mark,
  • Hubert Wadepohl and
  • Markus Enders

Beilstein J. Org. Chem. 2016, 12, 1372–1379, doi:10.3762/bjoc.12.131

Graphical Abstract
  • function is covalently bonded have been reported [37][38][39]. Some of those donors bind strongly, others weakly, to a particular transition metal ion. Examples, which are related to the work described here, are Cp ligands with olefinic [40][41][42][43][44][45][46][47][48][49][50][51][52] or with a nitrile
  • do not interact with the coordinatively saturated chromium centers. The coordination ability of the chosen donors D range from very weak (organofluorine) to medium (olefinic or aryl, respectively) and strong (nitrile). Activation with methylaluminoxane (MAO) leads to the formation of monomethyl
  • organofluorine substituent is connected by a side arm with suitable length. In addition to that we choose side arms with olefinic groups, a benzyl unit and a stronger nitrile donor group, respectively. The synthesis of the new ligand derivatives and the corresponding Cr complexes follows known procedures (Scheme
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Published 04 Jul 2016

Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

  • Mohammad Haji

Beilstein J. Org. Chem. 2016, 12, 1269–1301, doi:10.3762/bjoc.12.121

Graphical Abstract
  • prepared via this efficient method. One of the best strategies is based on the use of Bestmann–Ohira reagent (BOR) as the 1,3-dipole precursor. Smietana et al. accomplished a related three-component reaction with different aldehydes 211, nitrile derivatives 212 and dimethyldiazomethylphosphonate 213 to
  • adduct 214, resulting from condensation of aldehydes 211 and nitrile derivatives 212, lead to cyclo-adduct intermediates 216 which cyclize to phosphorylated pyrazoles 217. In this way, a one-pot three-component reaction of aldehydes 218, methyl ketones 219 and the Bestmann–Ohira reagent has been
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Published 21 Jun 2016

Cationic Pd(II)-catalyzed C–H activation/cross-coupling reactions at room temperature: synthetic and mechanistic studies

  • Takashi Nishikata,
  • Alexander R. Abela,
  • Shenlin Huang and
  • Bruce H. Lipshutz

Beilstein J. Org. Chem. 2016, 12, 1040–1064, doi:10.3762/bjoc.12.99

Graphical Abstract
  • arylureas at room temperature. A commercially available catalyst [Pd(MeCN)4](BF4)2 or a nitrile-free cationic palladium(II) complex generated in situ from the reaction of Pd(OAc)2 and HBF4, effectively catalyzes C–H activation/cross-coupling reactions between aryl iodides, arylboronic acids and acrylates
  • been previously observed in the coupling reactions of aryl iodides (in which even 40 mol % of MeCN was enough to almost completely shut down the reaction) [121]. In a cationic palladium(II) complex-catalyzed 1,4-addition of arylsilane, the nitrile-free cationic Pd(II) catalyst was much more effective
  • coordinating ability as a ligand on cationic palladium. On the other hand, when nitrile-free conditions were applied to urea 1f, with in situ-generated palladacycle (from Pd(OAc)2 and HBF4; Figure 8), followed by addition of the usual reagents, each reaction proceeded to give the anticipated acrylated/arylated
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Published 20 May 2016

1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis

  • Antonia Mielgo and
  • Claudio Palomo

Beilstein J. Org. Chem. 2016, 12, 918–936, doi:10.3762/bjoc.12.90

Graphical Abstract
  • formation [82] (Scheme 7b,2). 2.1 Synthesis of thiazol-4(5H)-ones 2 Thiazol-4(5H)-ones 2 can be easily prepared starting from the corresponding α-mercaptocarboxylic acid and nitrile. Treatment of both with triethylamine in refluxing ethanol [83] provides the expected thiazol-4(5H)-ones as yellow/green
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Published 09 May 2016
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