The first salen- type ligands derived from 3',5'-diamino- 3',5'-dideoxythymidine and -dideoxyxylothymidine and their corresponding copper(II) complexes

• Daniel Koth,
• Michael Gottschaldt,
• Helmar Görls and
• Karolin Pohle

Beilstein J. Org. Chem. 2006, 2, No. 17, doi:10.1186/1860-5397-2-17

• , Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands 10.1186/1860-5397-2-17 Abstract Background There are many nucleoside metal complexes known. According to observations made, only very few of them reveal their central ion to be co-ordinated by the sugar part of their

• containing three (DNA nucleosides) and four (RNA nucleosides) chiral centers respectively. Though the coordination of metal ions to nucleosides is well known, mostly the nucleobase interacts with the metal centre, and the chiral part of the nucleoside is not involved in the coordination. [1][2] Although a

• use as ligand in a copper(II) complex. [6] As far as we are aware, a metal complex with a 3',5'-diimino substituted nucleoside as a ligand has not been published by another source yet, and neither has its carbohydrate analogue. This study reports the synthesis of 3',5'-diamino-3',5'-dideoxy- and 3',5

Investigation of acetyl migrations in furanosides

• O. P. Chevallier and
• M. E. Migaud

Beilstein J. Org. Chem. 2006, 2, No. 14, doi:10.1186/1860-5397-2-14

• acetyl moieties. Such direct transesterification is intermolecular and while it has been observed in nucleoside-phosphoramidite and glycoside chemistry,[20][21][22][23] this alkoxide-promoted intermolecular acetyl migration process has been overlooked in furanosides. The isolated quantities of 1c and 1d

Stereoselective α-fluoroamide and α-fluoro- γ-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement

• Kenny Tenza,
• Julian S. Northen,
• David O'Hagan and
• Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2005, 1, No. 13, doi:10.1186/1860-5397-1-13

• intermediate in the synthesis of the anti-HIV nucleoside β-FddA1 6. [17][18] Results and discussion In order to undertake the appropriate zwitterionic aza-Claisen rearrangement reactions an efficient method for the production of the α-fluoro acid chloride substrates was required. A number of routes to 2

• iodolactonisation to generate α-fluoro-γ-butyrolactones, with good diastereoselectivities (~80–100% de). These molecules are useful intermediates for further derivatisation in the area of nucleoside analogue synthesis and the method is complementary to asymmetric electrophilic fluorination strategies for the