Knorr- Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids

• Brendon S. Gourlay,
• John H. Ryan and
• Jason A. Smith

Beilstein J. Org. Chem. 2008, 4, No. 3, doi:10.1186/1860-5397-4-3

• was consumed to give the hexahydroindolizidine 9 as the only observable product in ~80% yield. The chemoselectivity using these modified conditions is noteworthy while the carbonyl group is fully reduced the pyrrole group is selectively and partially reduced to the 3-pyrroline. This result was

The enantiospecific synthesis of (+)-monomorine I using a 5-endo- trig cyclisation strategy

• Malcolm B. Berry,
• Donald Craig,
• Philip S. Jones and
• Gareth J. Rowlands

Beilstein J. Org. Chem. 2007, 3, No. 39, doi:10.1186/1860-5397-3-39

• )aziridine 9 by ring-opening with 1 followed by protecting group interchange. Although this strategy was not as elegant as utilising an N-benzoylaziridine directly, we deemed it prudent not to subject such a species to nucleophilic attack due to reported issues with chemoselectivity. [17] Careful

Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones

• Aboul-Fetouh E. Mourad,
• Ashraf A. Aly,
• Hassan H. Farag and
• Eman A. Beshr

Beilstein J. Org. Chem. 2007, 3, No. 11, doi:10.1186/1860-5397-3-11

• . Analysis of the 1H NMR spectra of 4a-d provided answers on the chemoselectivity of the cyclocondensation. The δ values of the most carbon signals could be determined and assigned to the corresponding carbon atoms. For example, the 13C NMR spectrum of compound 4b revealed fourteen distinctive carbon signals

Hydrogenation of aromatic ketones, aldehydes, and epoxides with hydrogen and Pd(0)EnCat™ 30NP

• Steven V. Ley,
• Angus J. P. Stewart-Liddon,
• David Pears,
• Remedios H. Perni and
• Kevin Treacher

Beilstein J. Org. Chem. 2006, 2, No. 15, doi:10.1186/1860-5397-2-15

• ]. For these kind of substrates, catalysts based on Ni, Pd, and Pt have been used, and further efforts are directed toward improving the chemoselectivity and regioselectivity of this ring-opening reaction. [18][19] We now demonstrate that aryl aldehydes and ketones as well as aryl epoxides can also

Synthesis of 2,6-trans- disubstituted 5,6-dihydropyrans from (Z)-1,5-syn-endiols

• Eric M. Flamme and
• William R. Roush

Beilstein J. Org. Chem. 2005, 1, No. 7, doi:10.1186/1860-5397-1-7

• the cyclodehydration reactions of diol substrates were complicated by selectivity and reactivity issues (Figure 1 and Figure 2), we turned to an alternative strategy which would not rely on chemoselectivity in the cyclodehydration step. To this end, mesylates 11 were synthesized (Scheme 3). Treatment