Convergent synthesis of the pentasaccharide repeating unit of the biofilms produced by Klebsiella pneumoniae

• Arin Gucchait,
• Angana Ghosh and
• Anup Kumar Misra

Beilstein J. Org. Chem. 2019, 15, 431–436, doi:10.3762/bjoc.15.37

• removal of acetyl groups and benzylation using benzyl bromide and sodium hydroxide in one-pot [37] followed by removal of the p-methoxybenzyl group using DDQ [38] in 84% overall yield. Finally, stereoselective glycosylation of disaccharide trichloroacetimidate donor 18 with trisaccharide acceptor 23 in

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives

• Mikhail V. Makarov and
• Marie E. Migaud

Beilstein J. Org. Chem. 2019, 15, 401–430, doi:10.3762/bjoc.15.36

• generation of the protected β-NR+Br− 8a, which was isolated by crystallization from a 5:1 acetone/t-BuOMe mixture in 90% overall yield from 2a [27]. Note that dry acetonitrile was also used as a solvent in the glycosylation step instead of liquid SO2 but the yields of acetylated NR+Br− 8a were lowered (65

Study on the regioselectivity of the N-ethylation reaction of N-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

• Pedro N. Batalha,
• Luana da S. M. Forezi,
• Maria Clara R. Freitas,
• Nathalia M. de C. Tolentino,
• Ednilsom Orestes,
• José Walkimar de M. Carneiro,
• Fernanda da C. S. Boechat and
• Maria Cecília B. V. de Souza

Beilstein J. Org. Chem. 2019, 15, 388–400, doi:10.3762/bjoc.15.35

• treated with potassium carbonate followed by a dropwise addition of bromoethane, as the alkylating agent. This synthetic strategy provided exclusively the 1-ethylated product 7 with a good overall yield (80%, Scheme 1). Previous treatment of 5 with potassium carbonate promotes the establishment of an acid

Sigmatropic rearrangements of cyclopropenylcarbinol derivatives. Access to diversely substituted alkylidenecyclopropanes

• Guillaume Ernouf,
• Jean-Louis Brayer,
• Christophe Meyer and
• Janine Cossy

Beilstein J. Org. Chem. 2019, 15, 333–350, doi:10.3762/bjoc.15.29

• conditions, which were optimized for imidate 12a, enabled the formation of p-bromobenzylidene[(N-trichloroacetylamino)cyclopropane] 13a as a single (E)-isomer in 63% overall yield (two steps from the corresponding alcohol). Compound 13a was obtained in lower yield in the absence of a base (21%) or when DMF

Unexpected loss of stereoselectivity in glycosylation reactions during the synthesis of chondroitin sulfate oligosaccharides

• Teresa Mena-Barragán,
• José L. de Paz and
• Pedro M. Nieto

Beilstein J. Org. Chem. 2019, 15, 137–144, doi:10.3762/bjoc.15.14

• isolated in good 73% yield. Noteworthy, exclusive formation of the β-product was observed. Nevertheless, the glycosylation of 1 and 18 again provided a mixture of the corresponding α and β-tetrasaccharides 19α and 19β in 71% overall yield (1:2.9 α/β ratio). The use of acetonitrile as solvent and lower

• temperature (−20 ºC), typical conditions for favoring the formation of the β-bond, increased the β-selectivity (1:4 α/β ratio) but also decreased the overall yield (50%). Similarly, a loss of β-selectivity was observed at the hexasaccharide stage (Scheme 7). Tetrasaccharide acceptor 20 was prepared from 19β

Stereodivergent approach in the protected glycal synthesis of L-vancosamine, L-saccharosamine, L-daunosamine and L-ristosamine involving a ring-closing metathesis step

• Pierre-Antoine Nocquet,
• Aurélie Macé,
• Frédéric Legros,
• Jacques Lebreton,
• Gilles Dujardin,
• Sylvain Collet,
• Arnaud Martel,
• Bertrand Carboni and
• François Carreaux

Beilstein J. Org. Chem. 2018, 14, 2949–2955, doi:10.3762/bjoc.14.274

• )-geometry of the crotylboronate, while the 2,3-anti relationship can be rationalized by invoking Cornforth-like transition states [40][41][42][43]. Eventually, silylation of the homoallylic alcohol 12b afforded the expected compound 13b in 68% overall yield from 5 after purification, compared to 29% using a

• the syn diastereomer 18 in high stereoselectivity (93:7). After silylation of the free hydroxy group, the cleavage of the PMB ether with DDQ led to alcohol 20 in 77% yield for the two steps. Ring-closing metathesis of diene 21, obtained by O-vinylation of 20, gave the dihydropyran 22 in 53% overall

• yield for two steps. The silyl group of compound 22 was cleaved using tetrabutylammonium fluoride (TBAF) in THF to form alcohol 23 which was used directly in the next step [48]. At this stage, we envisioned that 23 could be also a key intermediate to access the ristosamine derivative by reversing the

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

• Eloi P. Coutant,
• Vincent Hervin,
• Glwadys Gagnot,
• Candice Ford,
• Racha Baatallah and
• Yves L. Janin

Beilstein J. Org. Chem. 2018, 14, 2853–2860, doi:10.3762/bjoc.14.264

• yields of α-hydroxyimino esters 2t–v reached 49, 59 and 62% from aldehydes 5t–v, respectively. Of note is that we also tried this reducing agent to improve the overall yield of the benzyloxy-bearing oxime 2ab, but to no avail. We next focused on the furan-bearing α-hydroxyimino esters such as compound

• % overall yield via α-hydroxyimino ester 9, but it also forced us to use borohydrides to avoid the furan ring hydrogenation. Accordingly, an extensive study of the reduction of compound 6ae with borohydrides was made. Trials included reactions run at 0 °C overnight, the use of wet ethanol or dry THF, the

• -ylmethylene)propanebis(thioate), the bisthioester homolog of compound 6ae [5]. Finally, the oximation of the pure malonate 3ae only led to a 64% yield of the corresponding α-hydroxyimino ester 2ae, thus accounting for the 33% overall yield reported in Table 1 when we proceeded without purification. It is only

Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

• Glwadys Gagnot,
• Vincent Hervin,
• Eloi P. Coutant,
• Sarah Desmons,
• Racha Baatallah,
• Victor Monnot and
• Yves L. Janin

Beilstein J. Org. Chem. 2018, 14, 2846–2852, doi:10.3762/bjoc.14.263

• salts. The use of tetramethylammonium borohydride did not increase the overall yield of 6n, however, a rather substantial improvement was observed when using sodium cyanoborohydride. Indeed, from pure acrylate 2n, a 70% yield of 6n was obtained, and in one pot starting from aldehyde 3n, a 48% overall

• yield of 6n was achieved. Moreover, without using an inert atmosphere for the initial condensation between furfural (3n) and ethyl nitroacetate (4) the overall yield of 6n dropped to 37% even when using sodium cyanoborohydride. The optimized conditions were then applied to aldehyde 3r and afforded a

• 12 in 32% overall yield via the nitro compound 11. We also investigated the reported [4] 1,4-addition of a methyl on compound 2n to prepare the β-methylated derivative 13. In our hands, a rather modest 43% yield of the expected adduct 13 was achieved from purified acrylate 2n. Again, the ensuing

Synthesis of mono-functionalized S-diazocines via intramolecular Baeyer–Mills reactions

• Miriam Schehr,
• Daniel Hugenbusch,
• Tobias Moje,
• Christian Näther and
• Rainer Herges

Beilstein J. Org. Chem. 2018, 14, 2799–2804, doi:10.3762/bjoc.14.257

• see Supporting Information File 1) is formed, which lowers the overall yield of S-diazocines 1–3 considerably. Further problems arise from the difficult separation of the azoxy compound from other byproducts. The yields of the azoxy reduction in the ball mill are varying between 18–46%. S-Diazocines

Synthesis of a tyrosinase inhibitor by consecutive ethenolysis and cross-metathesis of crude cashew nutshell liquid

• Jacqueline Pollini,
• Valentina Bragoni and
• Lukas J. Gooßen

Beilstein J. Org. Chem. 2018, 14, 2737–2744, doi:10.3762/bjoc.14.252

• subsequent hydrogenation step. Overall, the target compound was obtained in an overall yield of 61% based on the unsaturated anacardic acid content and 34% based on the crude CNSL. Keywords: cashew nutshell liquid; cross-metathesis; renewable feedstock; sustainable chemistry; tyrosinase inhibitor

• found that the tridecanyl substituted derivative ginkgolic acid (13:0, 3) exhibits the most promising inhibitory activity. While this modular approach is very appealing for drug-discovery, the use of expensive γ-resorcylic acid as the substrate basis and the low overall yield over several reaction steps

• mmol) scale yielding 72% of the hydrogenated product 3. Combined with the ethenolysis/precipitation step, the entire sequence afforded 61% overall yield based on unsaturated anacardic acids present in the CNSL (Scheme 4). Conclusion In conclusion, a straightforward sequence of an ethenolysis, cross

Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis

• Robby Vroemans,
• Yenthel Verhaegen,
• My Tran Thi Dieu and
• Wim Dehaen

Beilstein J. Org. Chem. 2018, 14, 2689–2697, doi:10.3762/bjoc.14.246

• desired product 5a was obtained in 67% yield, together with an oxidized ring opened side product 6 in 20% yield. The overall yield of 5a after two steps was 48%, considering that the 3-nitro-2H-chromene (3) was obtained in a yield of 71%. We continued our studies by verifying the obtained regiochemistry

• triethylamine was needed but the overall yield of 5a was still lower as it only reached 38%. With the obtained optimized conditions and proof of regioselectivity in hand, further investigation towards the generality of this three-component reaction was carried out by varying the substrate scope (Figure 1). We

Synthesis of cis-hydrindan-2,4-diones bearing an all-carbon quaternary center by a Danheiser annulation

• Gisela V. Saborit,
• Carlos Cativiela,
• Ana I. Jiménez,
• Josep Bonjoch and
• Ben Bradshaw

Beilstein J. Org. Chem. 2018, 14, 2597–2601, doi:10.3762/bjoc.14.237

• bromide to furnish cyclohexenone 4 in 86% overall yield over the two steps from 1. Additionally, the overall transformation from the starting material 2 was also performed in a one-pot sequence involving six reactions, namely, an intermolecular Michael reaction, aldol cyclization, intramolecular aza

• -Michael reaction, removal of a tert-butoxycarbonyl ester, base-promoted ring opening and tosylamide benzylation, without significant detrimental effect on the overall yield (see Supporting Information File 1). With the key precursor 4 in hand, the stage was set to study the Danheiser annulation step

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

• Xiaochen Du,
• Jianjun Huang,
• Anton A. Nechaev,
• Ruwei Yao,
• Jing Gong,
• Erik V. Van der Eycken,
• Olga P. Pereshivko and
• Vsevolod A. Peshkov

Beilstein J. Org. Chem. 2018, 14, 2572–2579, doi:10.3762/bjoc.14.234

• fact that the resulting cyclized products 8r and 8r’ were essentially inseparable. The best 8r/8r’ ratio could be obtained using hexafluoro-2-methylpropan-2-ol while the best overall yield was obtained using HFIP (Table 4, entry 2 versus entry 4). Conclusion We have elaborated a fast and diversity

Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives

• Nicholas G. Jentsch,
• Jared D. Hume,
• Emily B. Crull,
• Samer M. Beauti,
• Amy H. Pham,
• Julie A. Pigza,
• Jacques J. Kessl and
• Matthew G. Donahue

Beilstein J. Org. Chem. 2018, 14, 2529–2536, doi:10.3762/bjoc.14.229

• able to construct the desired benzene substituted quinoline 21 in six steps from 2-amino-4-bromobenzoic acid in 31% overall yield. Conclusion In conclusion, an efficient route for the synthesis of substituted quinolines 10a–h has been demonstrated from commercially available anthranilic acids AA

Practical tetrafluoroethylene fragment installation through a coupling reaction of (1,1,2,2-tetrafluorobut-3-en-1-yl)zinc bromide with various electrophiles

• Ken Tamamoto,
• Shigeyuki Yamada and
• Tsutomu Konno

Beilstein J. Org. Chem. 2018, 14, 2375–2383, doi:10.3762/bjoc.14.213

• % isolated yield. Then, 4t underwent Pd(0)-catalyzed Sonogashira cross-coupling reaction with phenylacetylene, producing the corresponding tolane derivative 4u with a CF2CF2 fragment in good yield (30% overall yield from 2-Zn). Consequently, 2-Zn is found to be a powerful tetrafluoroethylenating agent for

Non-metal-templated approaches to bis(borane) derivatives of macrocyclic dibridgehead diphosphines via alkene metathesis

• Tobias Fiedler,
• Michał Barbasiewicz,
• Michael Stollenz and
• John A. Gladysz

Beilstein J. Org. Chem. 2018, 14, 2354–2365, doi:10.3762/bjoc.14.211

• (in,in/out,out)-2·2BH3 (2%). Four of these structures are verified by independent syntheses. Second, 1,14-tetradecanedioic acid is converted (reduction, bromination, Arbuzov reaction, LiAlH4) to H2P((CH2)14)PH2 (10; 76% overall yield). The reaction with H3B·SMe2 gives 10·2BH3, which is treated with n

A novel and practical asymmetric synthesis of eptazocine hydrobromide

• Ruipeng Li,
• Zhenren Liu,
• Liang Chen,
• Jing Pan,
• Kuaile Lin and
• Weicheng Zhou

Beilstein J. Org. Chem. 2018, 14, 2340–2347, doi:10.3762/bjoc.14.209

• were optimized to obtain the product in excellent overall yield and purity. Keywords: alkylation; asymmetric catalysis; eptazocine; Mannich cyclization; Introduction Eptazocine hydrobromide (1, Scheme 1), (1S,6S)-1,4-dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methanobenzo[e]azonine-10-ol hydrobromide

Studies towards the synthesis of hyperireflexolide A

• G. Hari Mangeswara Rao

Beilstein J. Org. Chem. 2018, 14, 2106–2111, doi:10.3762/bjoc.14.185

• reported from our laboratory the synthesis of γ-lactone-fused cyclopentane derivative 5 from the respective Diels–Alder adduct in 5 steps with an overall yield of 29% [32]. Hydrolysis of dimethyl ketal 5 with MeSO3H in 1,2-DCE furnished γ-lactone-fused cyclopentanone 6 in 97% yield. Cyclopentanone 6 exists

Synthesis and photophysical studies of a multivalent photoreactive Ru^II-calix[4]arene complex bearing RGD-containing cyclopentapeptides

• Sofia Kajouj,
• Lionel Marcelis,
• Alice Mattiuzzi,
• Adrien Grassin,
• Damien Dufour,
• Pierre Van Antwerpen,
• Didier Boturyn,
• Eric Defrancq,
• Mathieu Surin,
• Julien De Winter,
• Pascal Gerbaux,
• Ivan Jabin and
• Cécile Moucheron

Beilstein J. Org. Chem. 2018, 14, 1758–1768, doi:10.3762/bjoc.14.150

• % yield. Diazotation followed by nucleophilic substitution with sodium azide gave the desired tetra-azido compound 4 in 56% overall yield from 3. It is noteworthy that the introduction of the azido groups on the calix[4]arene scaffold was clearly confirmed by the presence of an intense band at 2108 cm−1

Design, synthesis and structure of novel G-2 melamine-based dendrimers incorporating 4-(n-octyloxy)aniline as a peripheral unit

• Cristina Morar,
• Pedro Lameiras,
• Attila Bende,
• Gabriel Katona,
• Emese Gál and
• Mircea Darabantu

Beilstein J. Org. Chem. 2018, 14, 1704–1722, doi:10.3762/bjoc.14.145

• block A [1,3,5-tris(piperazinomethyl)benzene] consisted of the amination of 1,3,5-tris(bromomethyl)benzene with commercially available N-Boc-piperazine followed by deprotection, and was achieved according to the literature [39] (97% overall yield in our hands). Similarly, 2,4,6-tris[(4-hydroxy

Metal-free formal synthesis of phenoxazine

• Gabriella Kervefors,
• Antonia Becker,
• Chandan Dey and
• Berit Olofsson

Beilstein J. Org. Chem. 2018, 14, 1491–1497, doi:10.3762/bjoc.14.126

• a high-yielding O-arylation of a phenol with an unsymmetrical diaryliodonium salt to provide an ortho-disubstituted diaryl ether. This species was cyclized to acetylphenoxazine in moderate yield. The overall yield in the three-step sequence is 72% based on recovered diaryl ether. An interesting

•  7 and delivered N-acetylphenoxazine (2) in 72% overall yield over 3 steps. Combined with the literature yield for the deprotection, this would provide the target 1 in 65% overall yield based on recovered 3. The required starting materials in this route can easily be further substituted; hence we

• underwent an intramolecular N-arylation to provide the cyclized product 2. The overall yield in this three-step sequence is 72% based on recovered diaryl ether. Interestingly, an unusually stable iodine(III) intermediate was formed in the O-arylation. This species survived neutral work-up and could be

Enantioselective phase-transfer catalyzed alkylation of 1-methyl-7-methoxy-2-tetralone: an effective route to dezocine

• Ruipeng Li,
• Zhenren Liu,
• Liang Chen,
• Jing Pan and
• Weicheng Zhou

Beilstein J. Org. Chem. 2018, 14, 1421–1427, doi:10.3762/bjoc.14.119

• literature [10] (without resolution) to get compound 6a, and then 6a was transformed to dezocine with 23.0% overall yield and 100% purity. The mp, optical rotation value, MS and 1H NMR of the product were consistent with those in the literature [4][10]. Synthesis of dezocine by resolution. Synthesis of

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

• Mark Kelada,
• John M. D. Walsh,
• Robert W. Devine,
• Patrick McArdle and
• John C. Stephens

Beilstein J. Org. Chem. 2018, 14, 1222–1228, doi:10.3762/bjoc.14.104

• the pot and the reaction heated at the same temperature, 150 °C, under microwave irradiation for a further 2 h. The target pyrazolo[1,5-a]pyrimidinone was subsequently isolated in an overall yield of 52%. Once more, a significant improvement was observed using microwave conditions in comparison with

One hundred years of benzotropone chemistry

• Arif Dastan,
• Haydar Kilic and
• Nurullah Saracoglu

Beilstein J. Org. Chem. 2018, 14, 1120–1180, doi:10.3762/bjoc.14.98

• material, Ewing and Paquette designed and synthesized benzotropone 11 by an especially reliable route [54]. For this purpose, bisalkylation of o-xylylene dibromide (38) with tert-butyl lithioacetate (Rathke's salt) and subsequent Dieckmann cyclization provided simple access to 40 in 51% overall yield

Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

• Dan Liu,
• Ya-Li Guo,
• Jin Qu and
• Chi Zhang

Beilstein J. Org. Chem. 2018, 14, 1112–1119, doi:10.3762/bjoc.14.97

• coupling reagent, which was developed by Ye’s group in order to reduce racemization and side reactions [50]. The precursor 2 was obtained via successive deprotection of the C-terminal and the N-terminal protecting group of 14. The overall yield of this route is 28%. With the precursor 2 in hand, we then