The vicinal difluoro motif: The synthesis and conformation of erythro- and threo- diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives

• David O'Hagan,
• Henry S. Rzepa,
• Martin Schüler and
• Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2006, 2, No. 19, doi:10.1186/1860-5397-2-19

• determines the three dimensional structure of the unit cell. The threo-19 diastereoisomer was prepared by a similar aryl oxidation reaction on a diastereomerically pure sample of threo-13 and this allowed crystallisation of a sample of racemic threo-19. The X-ray structure in Figure 6 shows the molecule in

Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

• Karunananda Bombuwala,
• Thomas Kinstle,
• Vladimir Popik,
• Sonal O. Uppal,
• James B. Olesen,
• Jose Viña and
• Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

• for three-dimensional cell phenotypes, based on computer-assisted microscopy and sophisticated classification methods, shape data from treated cells were classified by reference to a cell line that became oncogenically transformed over a prolonged course of in vitro culture. Colchicine-treated cells

• ) made from a three-dimensional image. The VROs reconstructed from laser confocal scanning microscopy are shown in Supplemental data. In both untreated and treated cells, the + end 'comets' were concentrated near the cell edge and descended in arc-like patterns toward the substratum. In untreated cells

• , Pittsburgh, PA). The resulting three-dimensional images are displayed in Quickview on Apple Macintosh or Dell PC microcomputers. Microtubule arrangement as visualized by immunofluorescence localization of β-tubulin. Cells were treated with: A) 2 μM Colchitaxel, B) 12 μM Colchitaxel, or C) solvent vehicle