Allostreptopyrroles A–E, β-alkylpyrrole derivatives from an actinomycete Allostreptomyces sp. RD068384

• Marwa Elsbaey,
• Naoya Oku,
• Mohamed S. A. Abdel-Mottaleb and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2024, 20, 1981–1987, doi:10.3762/bjoc.20.174

• , Japan Computational Chemistry Lab, Department of Chemistry, Faculty of Science, Ain Shams University, 11566 Abbassia, Cairo, Egypt 10.3762/bjoc.20.174 Abstract Five new β-alkylpyrrole derivatives, allostreptopyrroles A–E (1–5), were isolated from the culture broth of Allostreptomyces RD068384. Their

• : Allostreptomyces; β-alkylpyrrole; conformer; cytotoxic; DFT; 4-formylpyrrole-2-carboxylic acid; Introduction β-Alkylpyrroles are key structural motifs in biomolecules and functional organic materials [1]. For instance, β-alkylpyrroles are the main building blocks for the life-essential tetrapyrrole pigments

• , Allostreptomyces was introduced as a new genus in the family Streptomycetaceae [21], and two species, A. psammosilenae [21] and A. indica [22], are currently known. Only two 22-membered macrolides were reported from this genus [23] until we recently isolated five polycyclic tetramate-class macrolactams from