4-(1-Methylamino)ethylidene-1,5-disubstituted pyrrolidine-2,3-diones: synthesis, anti-inflammatory effect and in silico approaches

• Nguyen Tran Nguyen,
• Vo Viet Dai,
• Luc Van Meervelt,
• Do Thi Thao and
• Nguyen Minh Thong

Beilstein J. Org. Chem. 2025, 21, 817–829, doi:10.3762/bjoc.21.65

• organic cation transporter 2 (OCT2) was examined, with OCT2 playing a pivotal role in the renal elimination of both xenobiotics and endogenous compounds. The predicted results suggest that none of the studied compounds act as OCT2 substrates. Toxicity was assessed using the Ames test, a widely accepted

• method for evaluating the mutagenic potential of compounds through bacterial assays. The Ames test results indicated that compounds 5c and 5e exhibited toxicity. Moreover, none of the tested molecules demonstrated potential for skin sensitization. Consequently, further experimental investigations are

Ultrasound-assisted Strecker synthesis of novel 2-(hetero)aryl-2-(arylamino)acetonitrile derivatives

• Emese Gal,
• Luiza Gaina,
• Hermina Petkes,
• Alexandra Pop,
• Castelia Cristea,
• Gabriel Barta,
• Dan Cristian Vodnar and
• Luminiţa Silaghi-Dumitrescu

Beilstein J. Org. Chem. 2020, 16, 2929–2936, doi:10.3762/bjoc.16.242

• that the C-(hetero)aryl-α-(arylamino)acetonitrile derivatives can be considered genotoxically safe and possibly antimutagenic. Keywords: Ames test; α-aminoacetonitriles; ferrocene; phenothiazine; SEM; single crystal XRD; sonochemistry; Introduction Sonochemistry can be considered as a major

• , ferrocene or benzene units was screened by the Salmonella mutagenicity assay (Ames test) [28] using S. typhimurium TA98 and TA100 strains. Results and Discussions Ultrasound-assisted synthesis The Strecker reaction between (hetero)aromatic aldimines and TMSCN in poly(ethylene glycol) (PEG)–water medium [18

• -recognized Ames test to screen the mutagenic potential for three selected C-substituted α-aminoacetonitriles comprising different hetero(aromatic) units: phenothiazinyl (2c), ferrocenyl (2i), and phenyl (2l), respectively. The similarity of the tested aminoacetonitrile series was set aside by the N

Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates

• Barbara Dmochowska,
• Karol Sikora,
• Anna Woziwodzka,
• Jacek Piosik and
• Beata Podgórska

Beilstein J. Org. Chem. 2016, 12, 1434–1439, doi:10.3762/bjoc.12.138

• using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic. Keywords: 6-bromohexyl D-glucopyranoside; microbiological

• activity using the Salmonella typhimurium TA98 strain in the Ames test. The Ames test is a well-established and routinely used bacterial mutagenicity assay for examining the safety of newly obtained compounds before they are commercially available. In this work, five out of eight tested QASs, namely, 4b

• positive control (C2) was considered 100%. Mutagenic activity of the QASs in the Ames test with histidine-dependent Salmonella typhimurium TA98 strain. A, 4a; B, 4b; C, 5a; D, 5b; E, 6a; F, 6b; G, 7a; H, 7b. C1 (marked in white), negative (water) control; C2 (marked in black), positive control (2-amino-3