Facile preparation of fluorine-containing 2,3-epoxypropanoates and their epoxy ring-opening reactions with various nucleophiles

• Yutaro Miyashita,
• Sae Someya,
• Tomoko Kawasaki-Takasuka,
• Tomohiro Agou and
• Takashi Yamazaki

Beilstein J. Org. Chem. 2024, 20, 2421–2433, doi:10.3762/bjoc.20.206

• -to-handle reagent, NaOCl·5H2O. Because very little has been disclosed about the reactivity of such 2,3-epoxyesters, their epoxy ring opening by a variety of nucleophiles was carried out and we succeeded in clarifying these chemo- as well as regioselective processes proceeding via the SN2 mechanism to

• a variety of Rf groups at the 3 position starting from the corresponding 3-Rf-acrylates 1 by the action of the low cost and easy-to-handle reagent, NaOCl·5H2O. The special feature of this process is the requirement of a very mild temperature of 0 °C which can be well compared to the previous one

Designed whole-cell-catalysis-assisted synthesis of 9,11-secosterols

• Marek Kõllo,
• Marje Kasari,
• Villu Kasari,
• Tõnis Pehk,
• Ivar Järving,
• Margus Lopp,
• Arvi Jõers and
• Tõnis Kanger

Beilstein J. Org. Chem. 2021, 17, 581–588, doi:10.3762/bjoc.17.52

• to its toxicity, the oxidation rate affording trans-diols was very slow in comparison to that for cis-diols. Using an even longer reaction time and stoichiometric amount of the reagent, diol 5 was not oxidized to the corresponding dicarbonyl compound 8. However, using NaOCl·5H2O as an oxidant [31

• ) NaBH4, EtOH/CH2Cl2 1:1, 2 h, rt, then acetone, H2O, NaIO4, overnight, rt, 99%; ii) Ac2O, p-TsOH (1 mol %), MW (800 W), 6 min, 52% for 3 and 33% for 4; iii) Ac2O, DMAP, Et3N, CH2Cl2, overnight, rt, 93%. Oxidation of diols 5 and 6 with NaOCl·5H2O. Enzymatic hydroxylation. Supporting Information

Metal-free mechanochemical oxidations in Ertalyte^® jars

• Andrea Porcheddu,
• Francesco Delogu,
• Lidia De Luca,
• Claudia Fattuoni and
• Evelina Colacino

Beilstein J. Org. Chem. 2019, 15, 1786–1794, doi:10.3762/bjoc.15.172

• l’Ecole Normale, 34296 Montpellier, Cedex 5, France 10.3762/bjoc.15.172 Abstract Aimed at eliminating or at least significantly reducing the use of solvents, sodium hypochlorite pentahydrate crystals (NaOCl·5H2O) in the presence of a catalytic amount of a nitrosyl radical (TEMPO or AZADO) have been

• a mechanochemical process. Keywords: AZADO; Ertalyte®; green chemistry; mechanochemistry; NaOCl·5H2O; selective oxidation; TEMPO; Introduction The conversion of primary and secondary alcohols to the corresponding carbonyl compounds (aldehydes and ketones, respectively) is of such importance in

• . In particular, in this study, we used sodium hypochlorite pentahydrate (NaOCl·5H2O) in the presence of a catalytic amount of a nitrosyl radical (TEMPO or AZADO) to induce mechanochemical oxidation reactions on suitably selected primary and secondary alcohols. Performed in a high-energy ball mill and