Anti-invasive and cytotoxic evaluation of a (+)-pinoresinol-based semisynthetic library against glioblastoma

• Chen Zhang,
• Kah Yean Lum,
• Jonathan M. White,
• Paul I. Forster,
• Nicholas Booth,
• Sunita A. Ramesh and
• Rohan A. Davis

Beilstein J. Org. Chem. 2026, 22, 691–704, doi:10.3762/bjoc.22.54

• Engineering, Flinders University, Bedford Park, SA 5042, Australia NatureBank, Griffith University, Brisbane, QLD 4111, Australia 10.3762/bjoc.22.54 Abstract The Australian endemic plant genus Eremophila has long been recognized for its unique chemical diversity, with numerous novel and bioactive compounds

• difficulties in collecting sufficient quantities of this plant part. Owing to access to Griffith University’s NatureBank biota repository, which contains 45 locally collected Eremophila samples, we were able to obtain more than 20 g of E. maculata seeds. Large-scale extraction and isolation studies on this

• -Aldrich. All solvents used for chromatography, UV–vis, ECD, [α]D, and MS were Honeywell Burdick & Jackson brand or Lab-Scan HPLC grade. H2O was filtered using a Sartorius Stedium Arium Pro VF ultrapure H2O system. Plant material E. maculata seeds used in these studies were obtained from the NatureBank

Investigations of amination reactions on an antimalarial 1,2,4-triazolo[4,3-a]pyrazine scaffold

• Henry S. T. Smith,
• Ben Giuliani,
• Kanchana Wijesekera,
• Kah Yean Lum,
• Sandra Duffy,
• Aaron Lock,
• Jonathan M. White,
• Vicky M. Avery and
• Rohan A. Davis

Beilstein J. Org. Chem. 2025, 21, 1126–1134, doi:10.3762/bjoc.21.90

• School of Chemistry and Bio21 Institute, The University of Melbourne, Melbourne, VIC 3010, Australia, NatureBank, Griffith University, Brisbane, QLD 4111, Australia 10.3762/bjoc.21.90 Abstract 1,2,4-Triazolo[4,3-a]pyrazines have previously been explored by the Open Source Malaria project as potent in

Discovery of ianthelliformisamines D–G from the sponge Suberea ianthelliformis and the total synthesis of ianthelliformisamine D

• Sasha Hayes,
• Yaoying Lu,
• Bernd H. A. Rehm and
• Rohan A. Davis

Beilstein J. Org. Chem. 2024, 20, 3205–3214, doi:10.3762/bjoc.20.266

• Sasha Hayes Yaoying Lu Bernd H. A. Rehm Rohan A. Davis Institute for Biomedicine and Glycomics, Griffith University, Don Young Road, Brisbane, 4111, Australia NatureBank, Griffith University, Don Young Road, Brisbane, 4111, Australia Centre for Cell Factories and Biopolymers, Griffith University

• from either Sigma or Aaron Chemicals. Sponge material The sponge sample was obtained from the NatureBank [23] biota library housed at the Institute for Biomedicine and Glycomics, Griffith University, Australia. A voucher specimen of Suberea ianthelliformis (NB6014998; phylum Porifera, class

• and 1H and 13C NMR spectra of synthetic compounds 4, 9, and 10. Acknowledgements We gratefully acknowledge NatureBank [23] for supply of the sponge sample that was investigated during these studies. Funding The authors acknowledge the Australian Research Council (ARC) for support toward NMR and MS

Synthesis and characterisation of new antimalarial fluorinated triazolopyrazine compounds

• Kah Yean Lum,
• Jonathan M. White,
• Daniel J. G. Johnson,
• Vicky M. Avery and
• Rohan A. Davis

Beilstein J. Org. Chem. 2023, 19, 107–114, doi:10.3762/bjoc.19.11

• , Australia Discovery Biology, Griffith University, Nathan, QLD 4111, Australia NatureBank, Griffith University, Nathan, QLD 4111, Australia 10.3762/bjoc.19.11 Abstract Nine new fluorinated analogues were synthesised by late-stage functionalisation using Diversinate™ chemistry on the Open Source Malaria (OSM

Using UHPLC–MS profiling for the discovery of new sponge-derived metabolites and anthelmintic screening of the NatureBank bromotyrosine library

• Sasha Hayes,
• Aya C. Taki,
• Kah Yean Lum,
• Joseph J. Byrne,
• Merrick G. Ekins,
• Robin B. Gasser and
• Rohan A. Davis

Beilstein J. Org. Chem. 2022, 18, 1544–1552, doi:10.3762/bjoc.18.164

• , 3010, Australia Biodiversity and Geosciences, Queensland Museum, Grey Street, Brisbane, 4101, Australia 10.3762/bjoc.18.164 Abstract In order to further expand the NatureBank open access compound library, chemical investigations of the Australian marine sponge, Ianthella basta, were undertaken since

• marine natural product, ianthesine E (2). The chemical structure of the new compound was determined following detailed spectroscopic and spectrometric data analysis. These two compounds (1 and 2) along with seven previously reported marine bromotyrosine alkaloids from the NatureBank open access library

• (6), hexadellin A (9) and bastadin 4 (5) showed inhibition towards larval motility after 72 h of exposure with IC50 values of 1.6 µM, 10.0 µM and 33.3 µM, respectively. Keywords: alkaloid; anthelmintic; biodiscovery; bromotyrosine; 5-debromopurealidin H; Ianthella; NatureBank; sponge; Introduction