Mild and efficient synthesis and base-promoted rearrangement of novel isoxazolo[4,5-b]pyridines

• Vladislav V. Nikol’skiy,
• Mikhail E. Minyaev,
• Maxim A. Bastrakov and
• Alexey M. Starosotnikov

Beilstein J. Org. Chem. 2024, 20, 1069–1075, doi:10.3762/bjoc.20.94

• ]triazol-4-yl)pyridines was observed. Keywords: aromatic nitro compounds; Boulton–Katritzky rearrangement; isoxazolo[4,5-b]pyridines; nucleophilic substitution; 1,2,3-triazoles; Introduction Nitrogen heterocycles represent a very important class of organic compounds that has found application in various

Continuous-flow synthesis of primary amines: Metal-free reduction of aliphatic and aromatic nitro derivatives with trichlorosilane

• Riccardo Porta,
• Alessandra Puglisi,
• Giacomo Colombo,
• Sergio Rossi and
• Maurizio Benaglia

Beilstein J. Org. Chem. 2016, 12, 2614–2619, doi:10.3762/bjoc.12.257

• full conversion of the starting material no further purification was required. Continuous flow reduction of 4-nitrobenzophenone using a 0.5 mL PTFE flow reactor. Continuous flow reduction of aromatic nitro compounds. Continuous-flow reduction of aliphatic nitro compounds. Synthesis of 2-(4’-chlrophenyl

Simple and rapid hydrogenation of p-nitrophenol with aqueous formic acid in catalytic flow reactors

• Rahat Javaid,
• Shin-ichiro Kawasaki,
• Akira Suzuki and
• Toshishige M. Suzuki

Beilstein J. Org. Chem. 2013, 9, 1156–1163, doi:10.3762/bjoc.9.129

• produced in the syntheses of various chemicals including dyes, pharmaceuticals, and anticorrosive lubricants [14][15][16]. The catalytic hydrogenation of aromatic nitro compounds with H2 has been studied extensively in the presence of Pd, Pt, Ni, and Rh metals [14][16][17][18][19][20][21][22]. In the light

• catalyzed with core–shell Au–Pd NPs and Au NPs [23][24][25][26]. Formic acid is another attractive H2 source because it is safe, easy to handle, and requires no high-pressure equipment. Formic acid and formate have been used as effective H2 donors in the catalytic transfer hydrogenation of aromatic nitro

• compounds [27][28][29][30][31]. Here we attempted the hydrogenation of p-nitrophenol with formic acid in catalytic flow-through tubular reactors. Because Pd-based catalysts have usually been regarded as the most active catalysts [27][28][32], we modified the inner surface of tubular reactors with thin Pd