Beilstein J. Org. Chem.2024,20, 1308–1319, doi:10.3762/bjoc.20.114
Diels–Alder reactions and can be used repeatedly without significant degradation. These materials also allow the reaction to be completed in less time, with less energy consumption and higher yields.
Keywords: biobasedsolvent; epoxyisoindoles; furanics; green chemistry; intramolecular Diels–Alder
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Graphical Abstract
Figure 1:
Reaction yields after seven uses of SSO and average recovery of the oil.
Beilstein J. Org. Chem.2023,19, 1146–1154, doi:10.3762/bjoc.19.82
resulted in a significant reduction in kinetics and selectivity (Table 1, entry 3). Other more green and biobasedsolvent alternatives, such as ethanol [36], can effectively replace the acetonitrile (for the complete scope of solvents, please consult Supporting Information File 1, Table S2), but reaction